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Txndc5 thioredoxin domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 105245, updated on 8-May-2016
Official Symbol
Txndc5provided by MGI
Official Full Name
thioredoxin domain containing 5provided by MGI
Primary source
MGI:MGI:2145316
See related
Ensembl:ENSMUSG00000038991 Vega:OTTMUSG00000035033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERp46; PC-TRP; AL022641
Orthologs
Location:
13; 13 A3.3
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (38500266..38528824, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (38592144..38620329, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40921 Neighboring gene bone morphogenetic protein 6 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IBA
Inferred from Biological aspect of Ancestor
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
thioredoxin domain-containing protein 5
Names
ER protein 46
endoplasmic reticulum protein ERp46
endoplasmic reticulum resident protein 46
plasma cell-specific thioredoxin-related protein
thioredoxin-like protein p46

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289598.1NP_001276527.1  thioredoxin domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001276527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and represents translation initiation at an in-frame downstream AUG, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154747, AK136046, AK224956, AY243534
    Consensus CDS
    CCDS79178.1
    UniProtKB/Swiss-Prot
    Q91W90
    UniProtKB/TrEMBL
    A0A0R4J1Y7, Q3UWX1
    Related
    ENSMUSP00000124516, OTTMUSP00000048638, ENSMUST00000162075, OTTMUST00000089098
    Conserved Domains (3) summary
    cd03005
    Location:82182
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:85323
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:256
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_001289599.1NP_001276528.1  thioredoxin domain-containing protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and coding region and represents translation initiation at a novel AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK225017, AY243534
    Consensus CDS
    CCDS79179.1
    UniProtKB/Swiss-Prot
    Q91W90
    UniProtKB/TrEMBL
    E9PXX7
    Related
    ENSMUSP00000124401, OTTMUSP00000048639, ENSMUST00000160653, OTTMUST00000089099
    Conserved Domains (3) summary
    cd03005
    Location:103203
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:2344
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:277
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_145367.4NP_663342.3  thioredoxin domain-containing protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_663342.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK224971, AK225023, AY243534
    Consensus CDS
    CCDS26463.1
    UniProtKB/Swiss-Prot
    Q91W90
    UniProtKB/TrEMBL
    Q3TEE8
    Related
    ENSMUSP00000041839, OTTMUSP00000048637, ENSMUST00000035988, OTTMUST00000089097
    Conserved Domains (2) summary
    cd03005
    Location:176276
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:52417
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    38500266..38528824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    39616443..39645003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)