CEBPD CCAAT/enhancer binding protein (C/EBP), delta [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CEBPDprovided by HGNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP), deltaprovided by HGNC
Primary source: HGNC:1835
See related: Ensembl:ENSG00000221869; HPRD:00297; MIM:116898; Vega:OTTHUMG00000162290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CELF; CRP3; C/EBP-delta; NF-IL6-beta
Summary: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

Help top of page

Genomic context

Location :: 8p11.2-p11.1

Sequence :: Chromosome: 8; NC_000008.10 (48649476..48650726, complement)

See CEBPD in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of AD pathogenesis.
Title: CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.
Src kinase activity downregulates C/EBP-delta protein but not mRNA levels through a SIAH2 E3 ligase-dependent mechanism.
Title: Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.
new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells
Title: C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α.
Data indicate that C/EBPdelta plays a role in late stages of keratinocyte differentiation.
Title: C/EBPδ gene targets in human keratinocytes.
HMDB kills cancer cells through activation of CEBPD pathways.
Title: CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells.
C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity.
Title: C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity.
Common allelic variants in CEBPD were not associated with obesity phenotypes in healthy White Northern European families.
Title: CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study.
found that C/EBPdelta promotes monoubiquitination of the Fanconi anemia complementation group D2 protein (FANCD2), which is necessary for its function in replication-associated DNA repair
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
C/EBPdelta expression may prevent the development of recurrences by inhibition of neoplastic growth in meningiomas
Title: The cell growth inhibitory transcription factor C/EBPdelta is expressed in human meningiomas in association with low histological grade and proliferation index.
Expression of CEBPD reduces cisplatin-induced reactive oxygen species and apoptosis in NTUB1 carcinoma cells by inducing the expression of copper/zinc-superoxide dismutase via direct promoter transactivation.
Title: Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells.

Submit: New GeneRIF Correction See all (36)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_005186.2	AAC51130.1	CEBPE	BIND	PubMed	C/EBP-epsilon interacts with C/EBP-delta to form a heterodimer.
NP_005186.2	NP_005216.1	E2F1	BIND	PubMed	C/EBP-delta interacts with E2F1.
NP_005186.2	NC_000003.9	LTF	BIND	PubMed	C/EBP-delta interacts with the lactoferrin promoter.
NP_005186.2	NP_000312.1	RB1	BIND	PubMed	C/EBP-delta interacts with Rb.
P49716	P49715	CEBPA	HPRD	PubMed
P49716	P17676	CEBPB	HPRD	PubMed
P49716	Q15744	CEBPE	HPRD	PubMed
P49716	P53567	CEBPG	HPRD	PubMed
P49716	Q92793	CREBBP	HPRD	PubMed
P49716	Q09472	EP300	HPRD	PubMed
P49716	P06400	RB1	HPRD	PubMed
P49716	Q04206	RELA	HPRD	PubMed
P49716	P17947	SPI1	HPRD	PubMed
BioGRID:107481	BioGRID:107480	CEBPB	BioGRID	PubMed	Reconstituted Complex
BioGRID:107481	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107481	BioGRID:108474	FANCD2	BioGRID	PubMed	Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western
BioGRID:107481	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107481	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107481	BioGRID:115106	HDAC4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107481	BioGRID:122828	IPO4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107481	BioGRID:119624	PIAS4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107481	BioGRID:111902	RELA	BioGRID	PubMed	Reconstituted Complex
BioGRID:107481	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107481	BioGRID:110264	SMAD4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107481	BioGRID:115861	SPAG5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107481	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107481	BioGRID:113515	TRIM26	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107481	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107481	BioGRID:119501	UBR5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107481	BioGRID:113348	XPO1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein dimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: CCAAT/enhancer-binding protein delta

Names: CCAAT/enhancer-binding protein delta; c/EBP delta; nuclear factor NF-IL6-beta

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005195.3 → NP_005186.2 CCAAT/enhancer-binding protein delta

Status: REVIEWED

Source sequence(s)

BC105109, BQ773696, M83667

Consensus CDS

CCDS6142.1

UniProtKB/Swiss-Prot

P49716

Related

ENSP00000386165, OTTHUMP00000221850, ENST00000408965, OTTHUMT00000368448

Conserved Domains (1) summary

cl02576
Location:191 – 243
Blast Score: 188

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

48649476..48650726, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

44112391..44113009, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC023991.9 (125194..126488)	None
genomic	CH471068.1	EAW86679.1
genomic	S63168.1	AAB27293.1
mRNA	BC094715.1	AAH94715.1
mRNA	BC105109.1	AAI05110.1
mRNA	BQ773696.1	None
mRNA	M83667.1	AAA59927.1
other-genetic	EU831483.1	ACE87170.1
other-genetic	EU831570.1	ACE86489.1