CIB1 calcium and integrin binding 1 (calmyrin) [Homo sapiens] - Gene

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Summary

Official Symbol: CIB1provided by HGNC
Official Full Name: calcium and integrin binding 1 (calmyrin)provided by HGNC
Primary source: HGNC:16920
See related: Ensembl:ENSG00000185043; HPRD:03800; MIM:602293; Vega:OTTHUMG00000149808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIB; KIP; KIP1; SIP2-28
Summary: The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q25.3-q26

Sequence :: Chromosome: 15; NC_000015.9 (90773477..90777279, complement)

See CIB1 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that CIB1 positively regulates cell migration and is necessary for the recruitment of FAK to the focal adhesions. Furthermore, CIB1-induced cell migration is dependent on MAP kinase signaling and its function is attenuated by PAK1
Title: Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling.
CIB1 may be used as a novel prognostic factor and possibly an attractive therapeutic target for hepatocellular carcinoma.
Title: Proteomic identification of CIB1 as a potential diagnostic factor in hepatocellular carcinoma.
CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain.
Title: Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth.
analysis of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain
Title: Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain.
Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
Title: Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
content of DNA-PKcs was significantly higher in A549 cells than in H1299 cells
Title: [Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity].
CIB1 may be a potential biomarker and target for therapeutic intervention of breast cancer.
Title: Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
CIB1 interacts with SK1 in a Ca(2+)-dependent manner at the previously identified "calmodulin-binding site" of SK1.
Title: Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.

Submit: New GeneRIF Correction See all (27)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006375.1	NP_003210.1	TERT	BIND	PubMed	KIP interacts with hTERT.
Q99828	Q01780	EXOSC10	HPRD	PubMed
Q99828	Q99689	FEZ1	HPRD	PubMed
Q99828	P09912	IFI6	HPRD	PubMed
Q99828	P08514	ITGA2B	HPRD	PubMed
Q99828	Q14596	NBR1	HPRD	PubMed
Q99828	P23760	PAX3	HPRD	PubMed
Q99828	Q9NYY3	PLK2	HPRD	PubMed
Q99828	Q9H4B4	PLK3	HPRD	PubMed
Q99828	P78527	PRKDC	HPRD	PubMed
Q99828	P49768	PSEN1	HPRD	PubMed
Q99828	P49810	PSEN2	HPRD	PubMed
Q99828	Q05397	PTK2	HPRD	PubMed
Q99828	P60763	RAC3	HPRD	PubMed
Q99828	O14746	TERT	HPRD	PubMed
Q99828	O95071	UBR5	HPRD	PubMed
Q99828	P42768	WAS	HPRD	PubMed
BioGRID:115774	BioGRID:111403	EXOSC10	BioGRID	PubMed	Two-hybrid
BioGRID:115774	BioGRID:109896	ITGB3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115774	BioGRID:110253	NBR1	BioGRID	PubMed	Two-hybrid
BioGRID:115774	BioGRID:113843	NRIP1	BioGRID	PubMed	Two-hybrid
BioGRID:115774	BioGRID:115988	PLK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115774	BioGRID:107663	PLK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115774	BioGRID:111577	PRKDC	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115774	BioGRID:111642	PSEN1	BioGRID	PubMed	Two-hybrid
BioGRID:115774	BioGRID:111643	PSEN2	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:115774	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115774	BioGRID:202030	Pax3	BioGRID	PubMed	Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:115774	BioGRID:111819	RAC3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:115774	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115774	BioGRID:119501	UBR5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
calcium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
cell adhesion	TAS Traceable Author Statement more info	PubMed
double-strand break repair	TAS Traceable Author Statement more info	PubMed
endomitotic cell cycle	IDA Inferred from Direct Assay more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info
response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
apical plasma membrane	IEA Inferred from Electronic Annotation more info
cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
filopodium	IEA Inferred from Electronic Annotation more info
membrane	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: calcium and integrin-binding protein 1

Names: calcium and integrin-binding protein 1; CIBP; calmyrin; kinase-interacting protein; DNA-PKcs-interacting protein; SNK-interacting protein 2-28; Snk interacting protein 2-28; calcium- and integrin-binding protein; calcium and integrin binding protein 1; DNA-dependent protein kinase interacting protein; calcium and integrin binding, protein kinase interacting protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006384.3 → NP_006375.2 calcium and integrin-binding protein 1

Status: VALIDATED

Source sequence(s)

AA769426, CD622547, U82226

Consensus CDS

CCDS10360.1

UniProtKB/Swiss-Prot

Q99828

Related

ENSP00000333873, OTTHUMP00000194684, ENST00000328649, OTTHUMT00000313419

Conserved Domains (2) summary

cd00051
Location:111 – 178
Blast Score: 122

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:113 – 177
Blast Score: 117

EF_hand_5; EF-hand domain pair

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

90773477..90777279, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

66885466..66889268, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB021866.1	BAA36281.1
genomic	AC091167.19 (104741..108428)	None
genomic	CH471101.1	EAX02087.1
		EAX02088.1
		EAX02089.1
		EAX02090.1
mRNA	AA769426.1	None
mRNA	AB451276.1	BAG70090.1
mRNA	AB451406.1	BAG70220.1
mRNA	BC000846.2	AAH00846.1
mRNA	CD622547.1	None
mRNA	CR456955.1	CAG33236.1
mRNA	JQ246073.1	AEZ06077.1
mRNA	U82226.1	AAC51106.1
mRNA	U83236.1	AAB39758.1
mRNA	U85611.1	AAB53387.1
other-genetic	DQ891196.2	ABM82122.1
other-genetic	DQ894379.2	ABM85305.1