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CEBPB CCAAT/enhancer binding protein (C/EBP), beta [ Homo sapiens (human) ]

Gene ID: 1051, updated on 14-May-2013

Summary

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Official Symbol: CEBPBprovided by HGNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP), betaprovided by HGNC
Primary source: HGNC:1834
Locus tag: PP9092
See related: Ensembl:ENSG00000172216; HPRD:01801; MIM:189965; Vega:OTTHUMG00000032715
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAP; CRP2; TCF5; IL6DBP; NF-IL6; C/EBP-beta
Summary: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 20q13.1

Sequence :: Chromosome: 20; NC_000020.10 (48807120..48809227)

See CEBPB in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The LIP isoform of CEBPB mediates a non-apoptotic cell death process via engulfment of neighboring cells.
Title: Cells expressing the C/EBPbeta isoform, LIP, engulf their neighbors.
In prostate cancer cells, S100A8 expression is stimulated by prostaglandin E2 via EP2 and EP4 receptors through activation of the protein kinase A signaling pathway and stimulation of CCAAT/enhancer-binding-protein-beta binding to the S100A8 promoter.
Title: Prostaglandin E2 stimulates S100A8 expression by activating protein kinase A and CCAAT/enhancer-binding-protein-beta in prostate cancer cells.
we identified the differentiation-associated transcription factor CCAAT/enhancer binding protein beta as a critical regulator of CCL20 gene expression in normal human keratinocytes.
Title: Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration.
these results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR.
Title: Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBPβ 3'UTR through competitive binding with HuR.
We showed that C/EBPbeta interacts with the proximal promoter of the gene ABCC6.
Title: ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the gene.
hepatitis C virus induced an increase in activation of the major gluconeogenic transcription factors including CEBPB, promoting gluconeogenic gene expression.
Title: Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β.
study demonstrates that the Src/Stat3 and C/EBP signaling pathways positively regulate the expression of the Jab1 oncogene; results show that Stat3 and LAP2 (C/EBP-beta2) are the two major transcription factors that contribute to Jab1 overexpression that leads to increased proliferation of breast cancer cells
Title: Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.
Data show that C/EBPalpha and C/EBPbeta promote Dio2 expression in the trophoblastic cell line JEG3 through a conserved CCAAT element, which is a novel key component of the Dio2 promoter code that confers tissue-specific expression of D2 in these cells.
Title: CCAAT/enhancer-binding proteins are key regulators of human type two deiodinase expression in a placenta cell line.
both expanded limbal NCs and HUVEC rejoined with LEPC to form spheres to upregulate expression of DeltaNp63alpha, CK15, and CEBPdelta, the former but not the latter abolished expression of CK12 keratin.
Title: Angiogenesis potential of human limbal stromal niche cells.
C/EBP-beta target genes in monocytic cells are summarized and resulting functions are described, including regulation of proliferation and differentiation as well as orchestration of processes of mainly the innate immune response. [review]
Title: Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage.

Submit: New GeneRIF Correction See all (189)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates C/EBPbeta expression in human mesenchymal stem cells	PubMed
Tat, p14	tat	Tat-C/EBPbeta association is mediated through cdk9, which phosphorylates C/EBPbeta	PubMed
	tat	Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production	PubMed
	tat	The synergistic interaction between C/EBP-2 and Tat with the subtype C LTR is observed in U-937 cells	PubMed
	tat	Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes	PubMed
	tat	Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes	PubMed
	tat	HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47)	PubMed
	tat	HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity	PubMed
	tat	HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia	PubMed
Vif, p23	vif	NF-IL6 facilitates the reverse transcription of HIV-1 by binding to and inhibiting the antiviral cytidine deaminase APOBEC3G. A mutation in NF-IL6 at Ser-288 weakens its binding to APOBEC3G and strongly inhibits HIV-1 replication	PubMed
Vpr, p15	vpr	HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88	PubMed
	vpr	Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6	PubMed
	vpr	HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005185.2	NP_004074.2	DDIT3	BIND	PubMed	DDIT3 (CHOP) interacts with CEBPB (NF-IL6).
NP_005185.2	NP_001955.1	EGR1	BIND	PubMed	Egr1 interacts with c/EBP-beta. This interaction was modeled on a demonstrated interaction between mouse Egr1 and human c/EBP-beta.
NP_005185.2	M34462.1	PRG2	BIND	PubMed	The MBP-P2 promoter interacts with C/EBP-beta.
NP_005185.2	NP_005350.1	SMAD4	BIND	PubMed	CEBPB (C/EBP-beta) interacts with SMAD4. This interaction was modeled on a demonstrated interaction between CEBPB and SMAD4, both from unspecified species.
P17676	P15336	ATF2	HPRD	PubMed
P17676	P18848	ATF4	HPRD	PubMed
P17676	Q9UQM7	CAMK2A	HPRD	PubMed
P17676	P10147	CCL3	HPRD	PubMed
P17676	P49715	CEBPA	HPRD	PubMed
P17676	P17676	CEBPB	HPRD	PubMed
P17676	P49716	CEBPD	HPRD	PubMed
P17676	P53567	CEBPG	HPRD	PubMed
P17676	P16220	CREB1	HPRD	PubMed
P17676	Q92793	CREBBP	HPRD	PubMed
P17676	P35638	DDIT3	HPRD	PubMed
P17676	P00533	EGFR	HPRD	PubMed
P17676	P18146	EGR1	HPRD	PubMed
P17676	P19419	ELK1	HPRD	PubMed
P17676	Q09472	EP300	HPRD	PubMed
P17676	P03372	ESR1	HPRD	PubMed
P17676	Q12778	FOXO1	HPRD	PubMed
P17676	P17096	HMGA1	HPRD	PubMed
P17676	P09429	HMGB1	HPRD	PubMed
P17676	P61978	HNRNPK	HPRD	PubMed
P17676	Q9NSC5	HOMER3	HPRD	PubMed
P17676	Q00613	HSF1	HPRD	PubMed
P17676	P28482	MAPK1	HPRD	PubMed
P17676	P27361	MAPK3	HPRD	PubMed
P17676	Q9ULK4	MED23	HPRD	PubMed
P17676	P10242	MYB	HPRD	PubMed
P17676	P01106	MYC	HPRD	PubMed
P17676	P19838	NFKB1	HPRD	PubMed
P17676	Q14978	NOLC1	HPRD	PubMed
P17676	P04150	NR3C1	HPRD	PubMed
P17676	Q9H7Z7	PTGES2	HPRD	PubMed
P17676	P06400	RB1	HPRD	PubMed
P17676	Q04206	RELA	HPRD	PubMed
P17676	Q15418	RPS6KA1	HPRD	PubMed
P17676	O75582	RPS6KA5	HPRD	PubMed
P17676	Q01196	RUNX1	HPRD	PubMed
P17676	Q13950	RUNX2	HPRD	PubMed
P17676	P84022	SMAD3	HPRD	PubMed
P17676	Q13485	SMAD4	HPRD	PubMed
P17676	P51532	SMARCA4	HPRD	PubMed
P17676	Q12824	SMARCB1	HPRD	PubMed
P17676	Q92922	SMARCC1	HPRD	PubMed
P17676	P08047	SP1	HPRD	PubMed
P17676	P17947	SPI1	HPRD	PubMed
P17676	Q01892	SPIB	HPRD	PubMed
P17676	P11831	SRF	HPRD	PubMed
P17676	P42229	STAT5A	HPRD	PubMed
P17676	P42226	STAT6	HPRD	PubMed
P17676	Q16594	TAF9	HPRD	PubMed
P17676	Q13263	TRIM28	HPRD	PubMed
BioGRID:107480	BioGRID:106862	AR	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:106957	ATF3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:249547	Atf2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:122654	BHLHE41	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:115760	CARM1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107480	BioGRID:107284	CASP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107291	CASP8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107458	CDK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107479	CEBPA	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107480	CEBPB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107481	CEBPD	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107483	CEBPG	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107775	CREB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107985	DAXX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:108016	DDIT3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:108278	EGR1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:116123	EHMT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:107480	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:107480	BioGRID:108597	FOXO1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:115083	HDAC9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:109402	HMGA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:109431	HNRNPK	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:109530	HSF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:108918	KAT2A	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107480	BioGRID:114375	KAT2B	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107480	BioGRID:111580	MAPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:107480	BioGRID:114829	MED23	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:114831	MED26	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:110687	MYB	BioGRID	PubMed	Co-crystal Structure
BioGRID:107480	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:110857	NFKB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:114654	NOLC1	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex
BioGRID:107480	BioGRID:109165	NR3C1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:110955	NRF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:111464	PPARG	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:111850	RARB	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex
BioGRID:107480	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:112022	RORA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107309	RUNX1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:110263	SMAD3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:110264	SMAD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:112479	SMARCA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:114045	SMARCA5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112482	SMARCB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112483	SMARCC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112553	SP3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112566	SPI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:112600	SRF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107480	BioGRID:112743	TAF9	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
C-MYB transcription factor network, organism-specific biosystem
C-MYB transcription factor network
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
FOXA1 transcription factor network, organism-specific biosystem
FOXA1 transcription factor network
FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem (from Pathway Interaction Database)
FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem
FOXA2 and FOXA3 transcription factor networks
IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
IFN-gamma pathway, organism-specific biosystem
IFN-gamma pathway
IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL4-mediated signaling events, organism-specific biosystem
IL4-mediated signaling events
IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL6-mediated signaling events, organism-specific biosystem
IL6-mediated signaling events
Keap1-Nrf2 Pathway, organism-specific biosystem (from WikiPathways)
Keap1-Nrf2 Pathway, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
Regulation of nuclear SMAD2/3 signaling
Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
Regulation of retinoblastoma protein, organism-specific biosystem
Regulation of retinoblastoma protein
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
Signaling mediated by p38-alpha and p38-beta
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

General gene information

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Markers

RH17476 (e-PCR)
- UniSTS:79118

D20S728 (e-PCR)
- UniSTS:3208

STS-H26183 (e-PCR)
- UniSTS:32399

Homology

Homologs of the CEBPB gene: The CEBPB gene is conserved in chimpanzee, dog, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA Inferred from Electronic Annotation more info
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
transcription factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acute-phase response	TAS Traceable Author Statement more info	PubMed
brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
embryonic placenta development	IEA Inferred from Electronic Annotation more info
immune response	TAS Traceable Author Statement more info	PubMed
induction of apoptosis	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
regulation of interleukin-6 biosynthetic process	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info
response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nuclear chromatin	IEA Inferred from Electronic Annotation more info
nuclear matrix	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: CCAAT/enhancer-binding protein beta

Names: CCAAT/enhancer-binding protein beta; TCF-5; nuclear factor NF-IL6; transcription factor 5; nuclear factor of interleukin 6; interleukin 6-dependent DNA-binding protein; liver-enriched transcriptional activator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029019.1 RefSeqGene

Range

4745..6852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005194.3 → NP_005185.2 CCAAT/enhancer-binding protein beta

Status: REVIEWED

Source sequence(s)

AW025406, BC007538, DB457615

Consensus CDS

CCDS13429.1

UniProtKB/Swiss-Prot

P17676

Related

ENSP00000305422, OTTHUMP00000031262, ENST00000303004, OTTHUMT00000079672

Conserved Domains (1) summary

pfam07716
Location:270 – 323
Blast Score: 191

bZIP_2; Basic region leucine zipper

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p10 Primary Assembly

Range

48807120..48809227

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

45555433..45557595

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018931.1 Alternate CHM1_1.0

Range

48778277..48780397

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01052774.1 (28343..29277)	None
genomic	ABBA01052775.1	None
genomic	AL161937.13 (35188..37295)	None
genomic	AMYH01011971.1 (181073..181661)	None
genomic	AMYH01011972.1	None
genomic	AY193834.1	AAN86350.1
genomic	CH471077.2	EAW75629.1
genomic	X52560.1	CAA36794.1
mRNA	AF289608.1	AAL55792.1
mRNA	AK291536.1	BAF84225.1
mRNA	AW025406.1	None
mRNA	BC005132.2	AAH05132.2
mRNA	BC007538.1	AAH07538.1
mRNA	BC021931.1	AAH21931.1
mRNA	BU753628.1	None
mRNA	D63161.1	BAA09637.1
mRNA	DB457615.1	None
mRNA	M98056.1	None
other-genetic	EU832661.1	ACE87752.1
other-genetic	EU832739.1	ACE87071.1