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CEBPB CCAAT/enhancer binding protein (C/EBP), beta [ Homo sapiens (human) ]

Gene ID: 1051, updated on 12-Apr-2014
Official Symbol
CEBPBprovided by HGNC
Official Full Name
CCAAT/enhancer binding protein (C/EBP), betaprovided by HGNC
Primary source
HGNC:1834
Locus tag
PP9092
See related
Ensembl:ENSG00000172216; HPRD:01801; MIM:189965; Vega:OTTHUMG00000032715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRP2; TCF5; IL6DBP; NF-IL6; C/EBP-beta
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Location :
20q13.1
Sequence :
Chromosome: 20; NC_000020.11 (50190583..50192690)
See CEBPB in Epigenomics, MapViewer

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927541 Neighboring gene uncharacterized LOC101927559 Neighboring gene uncharacterized LOC100506115 Neighboring gene uncharacterized LOC284751 Neighboring gene uncharacterized LOC101927586

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates C/EBPbeta expression in human mesenchymal stem cells PubMed
Tat, p14 tat Tat-C/EBPbeta association is mediated through cdk9, which phosphorylates C/EBPbeta PubMed
tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed
tat The synergistic interaction between C/EBP-2 and Tat with the subtype C LTR is observed in U-937 cells PubMed
tat Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes PubMed
tat Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes PubMed
tat HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47) PubMed
tat HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity PubMed
tat HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia PubMed
Vif, p23 vif NF-IL6 facilitates the reverse transcription of HIV-1 by binding to and inhibiting the antiviral cytidine deaminase APOBEC3G. A mutation in NF-IL6 at Ser-288 weakens its binding to APOBEC3G and strongly inhibits HIV-1 replication PubMed
Vpr, p15 vpr HIV-1 Vpr-induced IL-6 production depends on the activation of NFkappaB and the involvement of C/EBP-beta, TLR4, and MyD88 PubMed
vpr Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6 PubMed
vpr HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute-phase response TAS
Traceable Author Statement
more info
PubMed 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of interleukin-6 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription involved in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
CCAAT/enhancer-binding protein beta
Names
CCAAT/enhancer-binding protein beta
nuclear factor NF-IL6
transcription factor 5
nuclear factor of interleukin 6
interleukin 6-dependent DNA-binding protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029019.1 RefSeqGene

    Range
    4745..6852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001285878.1NP_001272807.1  CCAAT/enhancer-binding protein beta isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [b, also known as LAP (liver activating protein)] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AW025406, BC007538, DB457615
    UniProtKB/Swiss-Prot
    P17676
    Conserved Domains (1) summary
    cd12193
    Location:254302
    Blast Score: 93
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. NM_001285879.1NP_001272808.1  CCAAT/enhancer-binding protein beta isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform [c, also known as LIP (liver inhibitory protein)] represented in this RefSeq results from translation initiation at a downstream AUG start codon. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AW025406, BC007538, DB457615
    UniProtKB/Swiss-Prot
    P17676
    Conserved Domains (1) summary
    pfam07716
    Location:72125
    Blast Score: 167
    bZIP_2; Basic region leucine zipper
  3. NM_005194.3NP_005185.2  CCAAT/enhancer-binding protein beta isoform a

    See proteins identical to NP_005185.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (a, also known as LAP*) represented in this RefSeq results from translation initiation at the 5' most AUG start codon and is the longest isoform.
    Source sequence(s)
    AW025406, BC007538, DB457615
    Consensus CDS
    CCDS13429.1
    UniProtKB/Swiss-Prot
    P17676
    Related
    ENSP00000305422, OTTHUMP00000031262, ENST00000303004, OTTHUMT00000079672
    Conserved Domains (1) summary
    cd12193
    Location:277325
    Blast Score: 93
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38 Primary Assembly

    Range
    50190583..50192690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    45555433..45557595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    48711778..48713885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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