CEBPB CCAAT/enhancer binding protein (C/EBP), beta [ Homo sapiens ]

Gene ID: 1051, updated on 19-May-2012

Help top of page

Summary

Official Symbol: CEBPBprovided by HGNC
Official Full Name: CCAAT/enhancer binding protein (C/EBP), betaprovided by HGNC
Primary source: HGNC:1834
Locus tag: PP9092
See related: Ensembl:ENSG00000172216; HPRD:01801; MIM:189965; Vega:OTTHUMG00000032715
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAP; CRP2; TCF5; IL6DBP; NF-IL6; C/EBP-beta; MGC32080
Summary: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 20q13.1

Sequence :: Chromosome: 20; NC_000020.10 (48807376..48809212)

See CEBPB in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A striking activity of C/EBP is imaged predominantly in the brain of living C/EBP-luc transgenic mice in response to lipopolysaccharide, showing for the first time in vivo that C/EBP mediates the brain response to inflammation.
Title: Bioluminescence imaging of the brain response to acute inflammation in living C/EBP reporter mice.
Physical interaction is confirmed between human remodeling subunit RSF proteins C/EBPbeta, chromatin remodeling protein SNF2H, and apobec-1 complementation factor ACF1.
Title: Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.
Sumolylation of C/EBPbeta1 in breast cancer cells may be a mechanism to circumvent oncogene-induced senescence.
Title: Negative regulation of C/EBPbeta1 by sumoylation in breast cancer cells.
C/EBP is a newly identified transcriptional activator of the LMP1 gene, independent of the EBNA2 coactivator
Title: Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1.
amino-acid changes in the transcription factor CCAAT/enhancer binding protein-beta (CEBPB, also known as C/EBP-beta) in the stem-lineage of placental mammals changed the way it responds to cyclic AMP/protein kinase A (cAMP/PKA) signalling
Title: Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB.
RSK-C/EBPbeta phosphorylation pathway may contribute to the development of lung injury and fibrosis
Title: C/EBPβ-Thr217 phosphorylation signaling contributes to the development of lung injury and fibrosis in mice.
data demonstrate that C/EBPbeta is involved in expression of matrix metalloproteinase-3 and ADAMTS-5 in arthritic synovium and cartilage
Title: CCAAT/enhancer binding protein β regulates expression of matrix metalloproteinase-3 in arthritis.
The ERK_CEBP/beta intracellular signaling is a key inflammatory pathway that links phagocytosis of wear particles to inflammatory gene expression in osteoprogenitors.
Title: Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells.
CCAAT-enhancer binding protein beta expression and elevations in LIP play an important role in regulating cellular survival via suppression of anoikis
Title: LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis.
The -110 to -79 sequence segment upstream from the transcription initiation site of Neutrophil gelatinase-associated lipocalin (NGAL) is a TPA responsive element (TRE), and its induction is controlled by CCAAT-Enhancer-Binding Protein-beta.
Title: Neutrophil gelatinase-associated lipocalin in gastric carcinoma cells and its induction by TPA are controlled by C/EBPβ.

Submit: New GeneRIF Correction See all (175)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction between TGF-beta signaling proteins Smad-3 and Smad-4, and C/EBPbeta modulates basal and HIV-1 Tat-mediated transcription of the HIV-1 LTR promoter in astrocytes	PubMed
	tat	Interaction of C/EBPbeta and HIV-1 Tat stimulates MCP-1 transcription in astrocytes	PubMed
	tat	HIV-1 Tat induces an increase in C/EBPbeta binding activity through a direct binding interaction between Tat and C/EBPbeta that is mediated through the N-terminal, cysteine rich, and core regions of Tat (amino acids 1-47)	PubMed
	tat	HIV-1 Tat upregulates IL-6 expression by transactivating the IL-6 promoter, an effect mediated through enhancement of CAAT enhancer-binding protein (C/EBP; nuclear factor-IL-6) DNA binding activity	PubMed
	tat	HIV-1 Tat induces iNOS in human astroglia through the activation of NF-kappaB and C/EBPbeta, an effect that may participate in the pathogenesis of HIV-associated dementia	PubMed
Vpr	vpr	Upregulation of IL-6, IL-10, TNFalpha, and gamma interferon is linked to HIV-1 Vpr activation of NF-IL-6	PubMed
	vpr	HIV-1 Vpr activates NF-IL-6 resulting in an increase in IL-8 expression and IL-8 promoter activity and also increases transcription of NF-IL-6 enhancer-containing viral promoters	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_005185.2	NP_004074.2	DDIT3	BIND	PubMed	DDIT3 (CHOP) interacts with CEBPB (NF-IL6).
NP_005185.2	NP_001955.1	EGR1	BIND	PubMed	Egr1 interacts with c/EBP-beta. This interaction was modeled on a demonstrated interaction between mouse Egr1 and human c/EBP-beta.
NP_005185.2	M34462.1	PRG2	BIND	PubMed	The MBP-P2 promoter interacts with C/EBP-beta.
NP_005185.2	NP_005350.1	SMAD4	BIND	PubMed	CEBPB (C/EBP-beta) interacts with SMAD4. This interaction was modeled on a demonstrated interaction between CEBPB and SMAD4, both from unspecified species.
P17676	P15336	ATF2	HPRD	PubMed
P17676	P18848	ATF4	HPRD	PubMed
P17676	Q9UQM7	CAMK2A	HPRD	PubMed
P17676	P10147	CCL3	HPRD	PubMed
P17676	P49715	CEBPA	HPRD	PubMed
P17676	P17676	CEBPB	HPRD	PubMed
P17676	P49716	CEBPD	HPRD	PubMed
P17676	P53567	CEBPG	HPRD	PubMed
P17676	P16220	CREB1	HPRD	PubMed
P17676	Q92793	CREBBP	HPRD	PubMed
P17676	P35638	DDIT3	HPRD	PubMed
P17676	P00533	EGFR	HPRD	PubMed
P17676	P18146	EGR1	HPRD	PubMed
P17676	P19419	ELK1	HPRD	PubMed
P17676	Q09472	EP300	HPRD	PubMed
P17676	P03372	ESR1	HPRD	PubMed
P17676	Q12778	FOXO1	HPRD	PubMed
P17676	P17096	HMGA1	HPRD	PubMed
P17676	P09429	HMGB1	HPRD	PubMed
P17676	P61978	HNRNPK	HPRD	PubMed
P17676	Q9NSC5	HOMER3	HPRD	PubMed
P17676	Q00613	HSF1	HPRD	PubMed
P17676	P28482	MAPK1	HPRD	PubMed
P17676	P27361	MAPK3	HPRD	PubMed
P17676	Q9ULK4	MED23	HPRD	PubMed
P17676	P10242	MYB	HPRD	PubMed
P17676	P01106	MYC	HPRD	PubMed
P17676	P19838	NFKB1	HPRD	PubMed
P17676	Q14978	NOLC1	HPRD	PubMed
P17676	P04150	NR3C1	HPRD	PubMed
P17676	Q9H7Z7	PTGES2	HPRD	PubMed
P17676	P06400	RB1	HPRD	PubMed
P17676	Q04206	RELA	HPRD	PubMed
P17676	Q15418	RPS6KA1	HPRD	PubMed
P17676	O75582	RPS6KA5	HPRD	PubMed
P17676	Q01196	RUNX1	HPRD	PubMed
P17676	Q13950	RUNX2	HPRD	PubMed
P17676	P84022	SMAD3	HPRD	PubMed
P17676	Q13485	SMAD4	HPRD	PubMed
P17676	P51532	SMARCA4	HPRD	PubMed
P17676	Q12824	SMARCB1	HPRD	PubMed
P17676	Q92922	SMARCC1	HPRD	PubMed
P17676	P08047	SP1	HPRD	PubMed
P17676	P17947	SPI1	HPRD	PubMed
P17676	Q01892	SPIB	HPRD	PubMed
P17676	P11831	SRF	HPRD	PubMed
P17676	P42229	STAT5A	HPRD	PubMed
P17676	P42226	STAT6	HPRD	PubMed
P17676	Q16594	TAF9	HPRD	PubMed
P17676	Q13263	TRIM28	HPRD	PubMed
BioGRID:107480	BioGRID:106862	AR	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:106957	ATF3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:249547	Atf2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:122654	BHLHE41	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:115760	CARM1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107480	BioGRID:107458	CDK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107479	CEBPA	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107480	CEBPB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107481	CEBPD	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107483	CEBPG	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:107775	CREB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:108016	DDIT3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:108278	EGR1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:116123	EHMT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:107480	BioGRID:108597	FOXO1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:115083	HDAC9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:109402	HMGA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:109431	HNRNPK	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:109530	HSF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:108918	KAT2A	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107480	BioGRID:114375	KAT2B	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107480	BioGRID:111580	MAPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:107480	BioGRID:114829	MED23	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:114831	MED26	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:110687	MYB	BioGRID	PubMed	Co-crystal Structure
BioGRID:107480	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:110857	NFKB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:114654	NOLC1	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex
BioGRID:107480	BioGRID:109165	NR3C1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:110955	NRF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:111464	PPARG	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:111850	RARB	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:111860	RB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:112022	RORA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:107309	RUNX1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:110263	SMAD3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:110264	SMAD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:112479	SMARCA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112483	SMARCC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112553	SP3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112566	SPI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107480	BioGRID:112600	SRF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107480	BioGRID:112651	STAT3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107480	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107480	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107480	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA Inferred from Electronic Annotation more info
glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
transcription factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acute-phase response	TAS Traceable Author Statement more info	PubMed
anti-apoptosis	IEA Inferred from Electronic Annotation more info
brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
embryonic placenta development	IEA Inferred from Electronic Annotation more info
immune response	TAS Traceable Author Statement more info	PubMed
induction of apoptosis	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
mammary gland epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
regulation of interleukin-6 biosynthetic process	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nuclear chromatin	IEA Inferred from Electronic Annotation more info
nuclear matrix	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: CCAAT/enhancer-binding protein beta

Names: CCAAT/enhancer-binding protein beta; TCF-5; nuclear factor NF-IL6; transcription factor 5; nuclear factor of interleukin 6; interleukin 6-dependent DNA-binding protein; liver-enriched transcriptional activator protein

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029019.1 RefSeqGene

Range

4745..6852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005194.3 → NP_005185.2 CCAAT/enhancer-binding protein beta

Status: REVIEWED

Source sequence(s)

AW025406, BC007538, DB457615

Consensus CDS

CCDS13429.1

UniProtKB/Swiss-Prot

P17676

Related

ENSP00000305422, OTTHUMP00000031262, ENST00000303004, OTTHUMT00000079672

Conserved Domains (1) summary

cl02576
Location:270 – 323
Blast Score: 191

bZIP_1; bZIP transcription factor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

48807376..48809212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

45555689..45557580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL161937.13	CAC14276.1
genomic	AY193834.1	AAN86350.1
genomic	CH471077.2	EAW75629.1
genomic	X52560.1	CAA36794.1
mRNA	AF289608.1	AAL55792.1
mRNA	AK291536.1	BAF84225.1
mRNA	AW025406.1	None
mRNA	BC005132.2	AAH05132.2
mRNA	BC007538.1	AAH07538.1
mRNA	BC021931.1	AAH21931.1
mRNA	BU753628.1	None
mRNA	D63161.1	BAA09637.1
mRNA	DB457615.1	None
mRNA	M98056.1	None
other-genetic	EU832661.1	ACE87752.1
other-genetic	EU832739.1	ACE87071.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P17676.2	GenPept	UniProtKB/Swiss-Prot:P17676
Q99557	GenPept	UniProtKB/TrEMBL:Q99557
Q9BSC0	GenPept	UniProtKB/TrEMBL:Q9BSC0