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    SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B [ Homo sapiens ]

    Gene ID: 10509, updated on 11-May-2012

    Summary

    Official Symbol
    SEMA4Bprovided by HGNC
    Official Full Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bprovided by HGNC
    Primary source
    HGNC:10730
    Locus tag
    UNQ749/PRO1480
    See related
    Ensembl:ENSG00000185033; HPRD:10217; Vega:OTTHUMG00000172096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SemC; SEMAC; KIAA1745; MGC131831

    Genomic context

    Location :
    15q25
    Sequence :
    Chromosome: 15; NC_000015.9 (90728152..90772892)
    See SEMA4B in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene zinc finger protein 710 Neighboring gene isocitrate dehydrogenase 2 (NADP+), mitochondrial Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene calcium and integrin binding 1 (calmyrin)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NPR2 P78352 DLG4    HPRD  PubMed  
    Q9NPR2 O14908 GIPC1    HPRD  PubMed  
    Q9NPR2 O43157 PLXNB1    HPRD  PubMed  
    BioGRID:115767 BioGRID:126285 DCBLD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115767 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    semaphorin-4B
    Names
    semaphorin-4B
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020210.3NP_064595.2  semaphorin-4B precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
      Source sequence(s)
      AC091167
      Consensus CDS
      CCDS45347.1
      Related
      ENSP00000332204, OTTHUMP00000247637, ENST00000332496, OTTHUMT00000416809
      Conserved Domains (4) summary
      cd05872
      Location:594677
      Blast Score: 306
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      smart00630
      Location:70499
      Blast Score: 993
      Sema; semaphorin domain
      cd11257
      Location:61524
      Blast Score: 2364
      Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
      cl02601
      Location:525548
      Blast Score: 112
      PSI; Plexin repeat
    2. NM_198925.2NP_945119.1  semaphorin-4B precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate 5'UTR and transcription from an alternate promoter compared to variant 1. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
      Source sequence(s)
      AC091167
      Consensus CDS
      CCDS45347.1
      Related
      ENSP00000394720, OTTHUMP00000247638, ENST00000411539, OTTHUMT00000416810
      Conserved Domains (4) summary
      cd05872
      Location:594677
      Blast Score: 306
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      smart00630
      Location:70499
      Blast Score: 993
      Sema; semaphorin domain
      cd11257
      Location:61524
      Blast Score: 2364
      Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
      cl02601
      Location:525548
      Blast Score: 112
      PSI; Plexin repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      90728152..90772892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      66840233..66884886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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