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SEMA4B semaphorin 4B [ Homo sapiens (human) ]

Gene ID: 10509, updated on 8-May-2016
Official Symbol
SEMA4Bprovided by HGNC
Official Full Name
semaphorin 4Bprovided by HGNC
Primary source
HGNC:HGNC:10730
See related
Ensembl:ENSG00000185033 HPRD:10217; Vega:OTTHUMG00000172096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SemC; SEMAC
Orthologs
Location:
15q25
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (90184920..90229664)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90727985..90772897)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370966 Neighboring gene isocitrate dehydrogenase (NADP(+)) 2, mitochondrial Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene calcium and integrin binding 1 Neighboring gene tubulin tyrosine ligase like 13, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1745, MGC131831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
semaphorin-4B
Names
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324029.1NP_001310958.1  semaphorin-4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091167
  2. NM_001324030.1NP_001310959.1  semaphorin-4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091167
  3. NM_001324031.1NP_001310960.1  semaphorin-4B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091167
  4. NM_001324032.1NP_001310961.1  semaphorin-4B isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091167
  5. NM_001324033.1NP_001310962.1  semaphorin-4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091167
  6. NM_001324034.1NP_001310963.1  semaphorin-4B isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091167
  7. NM_020210.3NP_064595.2  semaphorin-4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_064595.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS45347.1
    UniProtKB/Swiss-Prot
    Q9NPR2
    UniProtKB/TrEMBL
    J3KNP4
    Related
    ENSP00000332204, OTTHUMP00000247637, ENST00000332496, OTTHUMT00000416809
    Conserved Domains (3) summary
    cd05872
    Location:594677
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11257
    Location:61524
    Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
    pfam01437
    Location:525549
    PSI; Plexin repeat
  8. NM_198925.2NP_945119.1  semaphorin-4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_945119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate 5' UTR and transcription from an alternate promoter compared to variant 1. Variants 1 and 2 are predicted to encode the same protein which is annotated as the largest open reading frame. Translation may intitiate at either of the first two AUG sites.
    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS45347.1
    UniProtKB/Swiss-Prot
    Q9NPR2
    UniProtKB/TrEMBL
    J3KNP4
    Related
    ENSP00000394720, OTTHUMP00000247638, ENST00000411539, OTTHUMT00000416810
    Conserved Domains (3) summary
    cd05872
    Location:594677
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11257
    Location:61524
    Sema_4B; The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B)
    pfam01437
    Location:525549
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    90184920..90229664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521160.1XP_011519462.1  

    Conserved Domains (3) summary
    cd05872
    Location:438521
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    pfam01437
    Location:369393
    PSI; Plexin repeat
    cl15693
    Location:1368
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    90570020..90614740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)