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tnk2b tyrosine kinase, non-receptor, 2b [ Esox lucius (northern pike) ]

Gene ID: 105024998, updated on 13-Mar-2024

Summary

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Gene symbol
tnk2b
Gene description
tyrosine kinase, non-receptor, 2b
See related
EnsemblRapid:ENSELUG00000016720
Gene type
protein coding
RefSeq status
MODEL
Organism
Esox lucius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; Esocidae; Esox
Also known as
tnk2
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
104 current fEsoLuc1.pri (GCF_011004845.1) 3 NC_047571.1 (31105449..31164934, complement)
103 previous assembly Eluc_v4 (GCF_004634155.1) Linkage Group LG03 NC_025970.4 (5470503..5530564)

Chromosome 3 - NC_047571.1Genomic Context describing neighboring genes Neighboring gene WW domain-containing adapter protein with coiled-coil Neighboring gene vertebrate ancient opsin-like Neighboring gene transferrin receptor 1a Neighboring gene tetratricopeptide repeat domain 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome and linkage map of the northern pike (Esox lucius): conserved synteny revealed between the salmonid sister group and the Neoteleostei. Rondeau EB, et al. PLoS One, 2014. PMID 25069045, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine kinase, non-receptor, 2b
Names
tyrosine kinase non receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Esox lucius Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fEsoLuc1.pri Primary Assembly

Genomic

  1. NC_047571.1 Reference fEsoLuc1.pri Primary Assembly

    Range
    31105449..31164934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034290420.1 → XP_034146311.1  tyrosine kinase, non-receptor, 2b isoform X5

    UniProtKB/TrEMBL
    A0A3P8YLD5
    Related
    ENSELUP00000016925.3, ENSELUT00000026400.3
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:610 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1023 → 1066
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1053 → 1092
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:139 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:460 → 525
    GTPase_binding; GTPase binding
    pfam11555
    Location:824 → 903
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:406 → 455
    SH3_9; Variant SH3 domain

  2. XM_034290416.1 → XP_034146307.1  tyrosine kinase, non-receptor, 2b isoform X3

    UniProtKB/TrEMBL
    A0A3P8YK80
    Related
    ENSELUP00000073964.2, ENSELUT00000047261.2
    Conserved Domains (8) summary
    cd09539
    Location:36 → 97
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:534 → 926
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1038 → 1081
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1068 → 1107
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:169 → 428
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:490 → 555
    GTPase_binding; GTPase binding
    pfam11555
    Location:839 → 918
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:436 → 485
    SH3_9; Variant SH3 domain

  3. XM_029117649.2 → XP_028973482.2  tyrosine kinase, non-receptor, 2b isoform X1

    UniProtKB/TrEMBL
    A0A3P8YK80
    Related
    ENSELUP00000080783.1, ENSELUT00000110832.1
    Conserved Domains (8) summary
    cd09539
    Location:36 → 97
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:640 → 879
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1053 → 1096
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1083 → 1122
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:169 → 428
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:490 → 555
    GTPase_binding; GTPase binding
    pfam11555
    Location:854 → 933
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:436 → 485
    SH3_9; Variant SH3 domain

  4. XM_034290423.1 → XP_034146314.1  tyrosine kinase, non-receptor, 2b isoform X5

    UniProtKB/TrEMBL
    A0A3P8YLD5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:610 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1023 → 1066
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1053 → 1092
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:139 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:460 → 525
    GTPase_binding; GTPase binding
    pfam11555
    Location:824 → 903
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:406 → 455
    SH3_9; Variant SH3 domain

  5. XM_029117658.2 → XP_028973491.2  tyrosine kinase, non-receptor, 2b isoform X4

    UniProtKB/TrEMBL
    A0A3P8YLD5
    Related
    ENSELUP00000016946.3, ENSELUT00000026434.3
    Conserved Domains (8) summary
    cd09539
    Location:32 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:530 → 922
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1034 → 1077
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1064 → 1103
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:165 → 424
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:486 → 551
    GTPase_binding; GTPase binding
    pfam11555
    Location:835 → 914
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:432 → 481
    SH3_9; Variant SH3 domain

  6. XM_034290414.1 → XP_034146305.1  tyrosine kinase, non-receptor, 2b isoform X2

    UniProtKB/TrEMBL
    A0A3P8YLD5
    Related
    ENSELUP00000016933.3, ENSELUT00000039964.3
    Conserved Domains (8) summary
    cd09539
    Location:32 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:636 → 875
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1049 → 1092
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1079 → 1118
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:165 → 424
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:486 → 551
    GTPase_binding; GTPase binding
    pfam11555
    Location:850 → 929
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:432 → 481
    SH3_9; Variant SH3 domain

  7. XM_034290426.1 → XP_034146317.1  tyrosine kinase, non-receptor, 2b isoform X5

    UniProtKB/TrEMBL
    A0A3P8YLD5
    Conserved Domains (8) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    PHA03247
    Location:610 → 849
    PHA03247; large tegument protein UL36; Provisional
    cd14274
    Location:1023 → 1066
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1053 → 1092
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:139 → 398
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:460 → 525
    GTPase_binding; GTPase binding
    pfam11555
    Location:824 → 903
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    pfam14604
    Location:406 → 455
    SH3_9; Variant SH3 domain
Nucleotide Protein
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