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SEMA6B semaphorin 6B [ Homo sapiens (human) ]

Gene ID: 10501, updated on 12-May-2016
Official Symbol
SEMA6Bprovided by HGNC
Official Full Name
semaphorin 6Bprovided by HGNC
Primary source
HGNC:HGNC:10739
See related
Ensembl:ENSG00000167680 HPRD:12322; MIM:608873; Vega:OTTHUMG00000182011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEMAN; semaZ; SEMA-VIB; SEM-SEMA-Y
Summary
This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (4542587..4581602, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4542600..4559771, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene perilipin 5 Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene uncharacterized LOC105372249 Neighboring gene ribosomal protein S10 pseudogene Neighboring gene TNF alpha induced protein 8 like 1

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
 
semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
semaphorin-6B
Names
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
semaphorin VIB
semaphorin Z
semaphorin-6Ba

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032108.3NP_115484.2  semaphorin-6B precursor

    See identical proteins and their annotated locations for NP_115484.2

    Status: REVIEWED

    Source sequence(s)
    AI825930, BC142617, DA818632, DB257858
    Consensus CDS
    CCDS12131.1
    UniProtKB/Swiss-Prot
    Q9H3T3
    Related
    ENSP00000467290, OTTHUMP00000268070, ENST00000586582, OTTHUMT00000458656
    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525561
    PSI; Plexin repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    4542587..4581602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527640.1XP_011525942.1  

    See identical proteins and their annotated locations for XP_011525942.1

    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525567
    PSI; Plexin repeat
  2. XM_011527639.1XP_011525941.1  

    See identical proteins and their annotated locations for XP_011525941.1

    Conserved Domains (2) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)
    pfam01437
    Location:525567
    PSI; Plexin repeat
  3. XM_011527641.1XP_011525943.1  

    Related
    ENSP00000465722, OTTHUMP00000268071, ENST00000586965, OTTHUMT00000458660
    Conserved Domains (1) summary
    cd11267
    Location:57524
    Sema_6B; The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    4542791..4559971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020241.2: Suppressed sequence

    Description
    NM_020241.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_133327.1: Suppressed sequence

    Description
    NM_133327.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.