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LOC105007210 CASP8 and FADD-like apoptosis regulator [ Esox lucius (northern pike) ]

Gene ID: 105007210, updated on 14-Dec-2023

Summary

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Gene symbol
LOC105007210
Gene description
CASP8 and FADD-like apoptosis regulator
See related
EnsemblRapid:ENSELUG00000009504
Gene type
protein coding
RefSeq status
MODEL
Organism
Esox lucius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; Esocidae; Esox
Also known as
cflar
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Genomic context

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Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
104 current fEsoLuc1.pri (GCF_011004845.1) 20 NC_047588.1 (44766310..44781949)
103 previous assembly Eluc_v4 (GCF_004634155.1) Linkage Group LG20 NC_025987.4 (966329..981316, complement)

Chromosome 20 - NC_047588.1Genomic Context describing neighboring genes Neighboring gene aerolysin-like protein Neighboring gene aerolysin-like protein Neighboring gene transient receptor potential cation channel subfamily M member 2 Neighboring gene protein FAM126B Neighboring gene uncharacterized LOC117593499 Neighboring gene disco-interacting protein 2 homolog A Neighboring gene sacsin molecular chaperone 2 Neighboring gene zinc finger protein 239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CASP8 and FADD-like apoptosis regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Esox lucius Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fEsoLuc1.pri Primary Assembly

Genomic

  1. NC_047588.1 Reference fEsoLuc1.pri Primary Assembly

    Range
    44766310..44781949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034288760.1 → XP_034144651.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/TrEMBL
    A0A3P8XWQ7
    Conserved Domains (2) summary
    cl00042
    Location:237 → 494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:92 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_020041530.2 → XP_019897089.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/TrEMBL
    A0A3P8XWQ7
    Related
    ENSELUP00000008917.2, ENSELUT00000004755.3
    Conserved Domains (2) summary
    cl00042
    Location:237 → 494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:92 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_010866052.5 → XP_010864354.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_010864354.1

    UniProtKB/TrEMBL
    A0A3P8XWQ7
    Conserved Domains (2) summary
    cl00042
    Location:237 → 494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:92 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_010866051.5 → XP_010864353.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_010864353.1

    UniProtKB/TrEMBL
    A0A3P8XWQ7
    Conserved Domains (2) summary
    cl00042
    Location:237 → 494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:92 → 172
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. XM_034288761.1 → XP_034144652.1  CASP8 and FADD-like apoptosis regulator isoform X2

    Conserved Domains (2) summary
    pfam01335
    Location:3 → 78
    DED; Death effector domain
    cl00042
    Location:140 → 397
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
Nucleotide Protein
Heading Accession and Version

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