NCOA2 nuclear receptor coactivator 2 [ Homo sapiens ]

Gene ID: 10499, updated on 19-May-2012

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Summary

Official Symbol: NCOA2provided by HGNC
Official Full Name: nuclear receptor coactivator 2provided by HGNC
Primary source: HGNC:7669
See related: Ensembl:ENSG00000140396; HPRD:09066; MIM:601993; Vega:OTTHUMG00000164671
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75; MGC138808
Summary: The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]

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Genomic context

Location :: 8q13.3

Sequence :: Chromosome: 8; NC_000008.10 (71024267..71316020, complement)

See NCOA2 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Univariate survival analysis revealed that high tif2 expression was associated with worse prognosis in astrocytic brain tumors
Title: Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis.
The novel HEY1-NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas
Title: Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.
Genetic aberrations and dysregulation in expression of p160/SRC coactivators and the ANCCA in breast cancer, prostate cancer, and other nonhormone-responsive cancers, are reviewed.
Title: The roles and action mechanisms of p160/SRC coactivators and the ANCCA coregulator in cancer.
Treatment of THP-1 cells with coenzyme Q10 significantly decreased expression of NCOA2.
Title: The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells.
we detected NCOA2 mutations neither in prostate cancers nor in other cancers
Title: Mutational analysis of NCOA2 gene in prostate cancer and other common cancers.
Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.
Title: Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.
SRC-2 and SRC-3 concomitantly promote human adipocyte differentiation by attenuating phospho-PPARgamma-Serine114 and modulating PPARgamma cellular heterogeneity.
Title: Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis.
the hepatic AMPK-SRC-2 axis as an energy rheostat
Title: Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction See all (39)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex	PubMed
	tat	The p160 nuclear receptor co-activator GRIP1 binds to the N-terminal region of HIV-1 Tat (amino acids 1-40) through its basic helix-loop-helix domain (amino acids 1-97) and enhances the transactivating activity of Tat	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006531.1	NP_001612.1	AHR	BIND	PubMed	AHR interacts with NCOA2 (TIF2).
NP_006531.1	AAS45544.1	ANKRD11	BIND	PubMed	ANCO-1 interacts with TIF2. This interaction was modeled on a demonstrated interaction between human ANCO-1 and TIF2 from an unspecified species.
NP_006531.1	NP_000035.2	AR	BIND	PubMed	GRIP1 interacts with AR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human AR.
NP_006531.1	NP_001231.2	CCNT1	BIND	PubMed	Cyclin T1 interacts with GRIP1.
NP_006531.1	NP_001420.2	EP300	BIND	PubMed	GRIP1 interacts with p300. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human p300.
NP_006531.1	NP_000116.1	ESR1	BIND	PubMed	ER alpha interacts with TIF2. This interaction was modeled on a demonstrated interaction between TIF2 from an unspecified source and human ER alpha.
NP_006531.1	NP_000167.1	NR3C1	BIND	PubMed	GR-alpha interacts with GRIP1.
NP_006531.1	NP_000955.1	RARA	BIND	PubMed	GRIP1 interacts with RAR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RAR.
NP_006531.1	NP_002948.1	RXRA	BIND	PubMed	GRIP1 interacts with RXR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RXR.
NP_006531.1	NP_000452.2	THRB	BIND	PubMed	GRIP1 interacts with TR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human TR.
NP_006531.1	NP_000367.1	VDR	BIND	PubMed	GRIP1 interacts with VDR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human VDR.
Q15596	P35609	ACTN2	HPRD	PubMed
Q15596	P35869	AHR	HPRD	PubMed
Q15596	Q6UB99	ANKRD11	HPRD	PubMed
Q15596	P10275	AR	HPRD	PubMed
Q15596	P27540	ARNT	HPRD	PubMed
Q15596	Q86X55	CARM1	HPRD	PubMed
Q15596	P30281	CCND3	HPRD	PubMed
Q15596	O60563	CCNT1	HPRD	PubMed
Q15596	P11802	CDK4	HPRD	PubMed
Q15596	Q92793	CREBBP	HPRD	PubMed
Q15596	P35222	CTNNB1	HPRD	PubMed
Q15596	Q92841	DDX17	HPRD	PubMed
Q15596	P17844	DDX5	HPRD	PubMed
Q15596	Q07687	DLX2	HPRD	PubMed
Q15596	P56178	DLX5	HPRD	PubMed
Q15596	Q09472	EP300	HPRD	PubMed
Q15596	P03372	ESR1	HPRD	PubMed
Q15596	O95718	ESRRB	HPRD	PubMed
Q15596	Q9Y692	GMEB1	HPRD	PubMed
Q15596	Q16665	HIF1A	HPRD	PubMed
Q15596	P41235	HNF4A	HPRD	PubMed
Q15596	P05412	JUN	HPRD	PubMed
Q15596	Q12840	KIF5A	HPRD	PubMed
Q15596	P33176	KIF5B	HPRD	PubMed
Q15596	Q06413	MEF2C	HPRD	PubMed
Q15596	Q15596	NCOA2	HPRD	PubMed
Q15596	P43699	NKX2-1	HPRD	PubMed
Q15596	P04150	NR3C1	HPRD	PubMed
Q15596	P22736	NR4A1	HPRD	PubMed
Q15596	P04000	OPN1LW	HPRD	PubMed
Q15596	Q9Y6X2	PIAS3	HPRD	PubMed
Q15596	P37231	PPARG	HPRD	PubMed
Q15596	Q13136	PPFIA1	HPRD	PubMed
Q15596	Q99873	PRMT1	HPRD	PubMed
Q15596	P28065	PSMB9	HPRD	PubMed
Q15596	P35398	RORA	HPRD	PubMed
Q15596	P19793	RXRA	HPRD	PubMed
Q15596	HUEL	SLC30A9	HPRD	PubMed
Q15596	Q969G3	SMARCE1	HPRD	PubMed
Q15596	Q9Y5L9	SRCAP	HPRD	PubMed
Q15596	P63165	SUMO1	HPRD	PubMed
Q15596	P37243	THRB	HPRD	PubMed
Q15596	P11473	VDR	HPRD	PubMed
Q15596	Q04917	YWHAH	HPRD	PubMed
BioGRID:115761	BioGRID:106699	AHR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:118888	ANKRD11	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:106898	ARNT	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:115761	BioGRID:107027	ATR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:107140	BRCA1	BioGRID	PubMed	Protein-peptide; Reconstituted Complex
BioGRID:115761	BioGRID:107243	CAD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:115760	CARM1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:115761	BioGRID:120212	CC2D1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:107336	CCND3	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:107343	CCNT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:107454	CDK4	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115761	BioGRID:115776	DDX17	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:108021	DDX5	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex
BioGRID:115761	BioGRID:117243	EID1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:108404	ESR2	BioGRID	PubMed	FRET
BioGRID:115761	BioGRID:108406	ESRRB	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:108636	FOS	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115761	BioGRID:109414	HNF4A	BioGRID	PubMed	Two-hybrid
BioGRID:115761	BioGRID:109538	HSPA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:110284	MAGEA11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:110372	MEF2C	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification
BioGRID:115761	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:115761	BioGRID:112936	NKX2-1	BioGRID	PubMed	Two-hybrid
BioGRID:115761	BioGRID:109165	NR3C1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
BioGRID:115761	BioGRID:201708	Ncoa2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:111463	PPARD	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:111464	PPARG	BioGRID	PubMed	FRET; Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:114072	PPFIA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:114069	PPFIA4	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:109512	PRMT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:111849	RARA	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:112168	RXRA	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:116597	SNW1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:115761	BioGRID:115329	SRA1	BioGRID	PubMed	Phenotypic Enhancement; Protein-RNA
BioGRID:115761	BioGRID:112655	STAT6	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:208275	Smarce1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115761	BioGRID:112761	TAT	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:118878	TBK1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:115761	BioGRID:112923	THRA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115761	BioGRID:112924	THRB	BioGRID	PubMed	Two-hybrid
BioGRID:115761	BioGRID:115836	TXNRD2	BioGRID	PubMed	Two-hybrid
BioGRID:115761	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:119501	UBR5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:114173	USO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115761	BioGRID:113264	VDR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115761	BioGRID:116340	WDHD1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
PDZ domain binding	IEA Inferred from Electronic Annotation more info
chromatin binding	IEA Inferred from Electronic Annotation more info
histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
ligand-dependent nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
ligand-dependent nuclear receptor transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
nuclear hormone receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info
thyroid hormone receptor coactivator activity	IEA Inferred from Electronic Annotation more info
transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
androgen receptor signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed
cellular lipid metabolic process	TAS Traceable Author Statement more info
cerebellum development	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
microtubule	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	NAS Non-traceable Author Statement more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
presynaptic active zone	IEA Inferred from Electronic Annotation more info
rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: nuclear receptor coactivator 2

Names: nuclear receptor coactivator 2; hTIF2; transcriptional intermediary factor 2; class E basic helix-loop-helix protein 75; glucocorticoid receptor-interacting protein-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006540.2 → NP_006531.1 nuclear receptor coactivator 2

Status: VALIDATED

Source sequence(s)

AW504723, CK141607, X97674

Consensus CDS

CCDS47872.1

UniProtKB/Swiss-Prot

Q15596

Related

ENSP00000399968, OTTHUMP00000227193, ENST00000452400, OTTHUMT00000379696

Conserved Domains (5) summary

cd00130
Location:123 – 213
Blast Score: 134

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08815
Location:1071 – 1116
Blast Score: 186

Nuc_rec_co-act; Nuclear receptor coactivator

pfam07469
Location:1281 – 1336
Blast Score: 111

DUF1518; Domain of unknown function (DUF1518)

pfam08832
Location:649 – 709
Blast Score: 201

SRC-1; Steroid receptor coactivator

cl00081
Location:35 – 88
Blast Score: 106

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

71024267..71316020, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

66517566..66809329, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC021558.10	None
genomic	AC022730.7 (36144..39176)	None
genomic	AC084251.13 (142555..181399)	None
genomic	AC090731.5 (7599..124629)	None
genomic	CH471068.1	EAW86963.1
genomic	CQ834204.1	CAH05317.1
mRNA	AK298528.1	BAG60730.1
mRNA	AK308426.1	None
mRNA	AW504723.1	None
mRNA	BC092442.1	AAH92442.1
mRNA	BC114383.1	AAI14384.1
mRNA	CK141607.1	None
mRNA	EF374064.1	ABN46991.1
mRNA	X97674.1	CAA66263.1