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LINC02210-CRHR1 LINC02210-CRHR1 readthrough [ Homo sapiens (human) ]

Gene ID: 104909134, updated on 20-Nov-2023

Summary

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Official Symbol
LINC02210-CRHR1provided by HGNC
Official Full Name
LINC02210-CRHR1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:51483
See related
Ensembl:ENSG00000263715 AllianceGenome:HGNC:51483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGC57346-CRHR1; CRHR1-IT1-CRHR1
Summary
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]
Expression
Broad expression in brain (RPKM 3.0), testis (RPKM 2.3) and 23 other tissues See more
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Genomic context

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See LINC02210-CRHR1 in Genome Data Viewer
Location:
17q21.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45620346..45835828)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46482030..46697461)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43697712..43913194)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43677957-43678654 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43695849-43696828 Neighboring gene ribosomal protein S26 pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 2210 Neighboring gene uncharacterized LOC105371802 Neighboring gene ADP ribosylation factor 2, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:43782244-43783443 Neighboring gene Sharpr-MPRA regulatory region 9533 Neighboring gene uncharacterized LOC107985028 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43823543-43824208 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43822876-43823542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43828999-43829910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43835142-43835642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43840160-43840660 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43848965-43849573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43862413-43862913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43869433-43869933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43883739-43884240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43884241-43884740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43890849-43891705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43900915-43901416 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43917814-43918023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43922169-43923153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43923154-43924137 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43971863-43972748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43972749-43973634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43974521-43975405 Neighboring gene MAPT intronic transcript 1 Neighboring gene microtubule associated protein tau

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human protein factory for converting the transcriptome into an in vitro-expressed proteome, Goshima N, et al. Nat Methods, 2008 Dec. PMID 19054851
  2. The genomic organization of the human corticotropin-releasing factor type-1 receptor. Sakai K, et al. Gene, 1998 Sep 28. PMID 9757017
  3. Structure of class B GPCR corticotropin-releasing factor receptor 1. Hollenstein K, et al. Nature, 2013 Jul 25. PMID 23863939
  4. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. Pioszak AA, et al. J Biol Chem, 2008 Nov 21. PMID 18801728, Free PMC Article
  5. Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. Tao J, et al. Mol Pharmacol, 2008 Jun. PMID 18292205

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Clone Names

  • FLJ60266, FLJ60308

General protein information

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Preferred Names
CRHR1-IT1-CRHR1 protein
Names
CRHR1-IT1-CRHR1 readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256299.3 → NP_001243228.1  CRHR1-IT1-CRHR1 protein isoform 5

    See identical proteins and their annotated locations for NP_001243228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure, and it thus differs in the 5' UTR, initiates translation at a downstream in-frame start codon, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 6. The encoded isoform (5) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 6.
    Source sequence(s)
    AC217771, FJ543100
    Related
    ENSP00000488912.1, ENST00000634540.1
    Conserved Domains (2) summary
    cd14964
    Location:14 → 40
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 205
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001303016.1 → NP_001289945.1  CRHR1-IT1-CRHR1 protein isoform 6

    See identical proteins and their annotated locations for NP_001289945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longer isoform (6).
    Source sequence(s)
    AC217771, AK297590, FJ543100
    UniProtKB/TrEMBL
    B4DMR5
    Conserved Domains (1) summary
    pfam00002
    Location:15 → 212
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    45620346..45835828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    952322..1168458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    322470..537950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    46482030..46697461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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