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CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) [ Homo sapiens (human) ]

Gene ID: 10487, updated on 8-May-2016
Official Symbol
CAP1provided by HGNC
Official Full Name
CAP, adenylate cyclase-associated protein 1 (yeast)provided by HGNC
Primary source
HGNC:HGNC:20040
See related
Ensembl:ENSG00000131236 HPRD:09869; Vega:OTTHUMG00000004493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; CAP1-PEN
Summary
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p34.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (40040240..40072649)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40505912..40538321)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 2A Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene uncharacterized LOC105378669 Neighboring gene uncharacterized LOC105378670 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene ornithine decarboxylase antizyme 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
  • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
    Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
  • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
    Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
ameboidal-type cell migration IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP 1
testis secretory sperm-binding protein Li 218p

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105530.1NP_001099000.1  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_001099000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC020367, BC095440, BI460362, BM772471, BP391532
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518
    UniProtKB/TrEMBL
    D3DPU2
    Related
    ENSP00000361883, OTTHUMP00000004820, ENST00000372797, OTTHUMT00000013109
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4305
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319474
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. NM_006367.3NP_006358.1  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_006358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK222513, BC020367, BC095440, BI460362, BM772471, BP391532
    Consensus CDS
    CCDS41309.1
    UniProtKB/Swiss-Prot
    Q01518
    UniProtKB/TrEMBL
    D3DPU2
    Related
    ENSP00000361891, OTTHUMP00000004821, ENST00000372805, OTTHUMT00000013110
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4305
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319474
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    40040240..40072649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540509.1XP_011538811.1  

    See identical proteins and their annotated locations for XP_011538811.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4305
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319474
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. XM_011540515.1XP_011538817.1  

    See identical proteins and their annotated locations for XP_011538817.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  3. XM_011540510.1XP_011538812.1  

    See identical proteins and their annotated locations for XP_011538812.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4305
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319474
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  4. XM_011540512.1XP_011538814.1  

    See identical proteins and their annotated locations for XP_011538814.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  5. XM_011540514.1XP_011538816.1  

    See identical proteins and their annotated locations for XP_011538816.1

    UniProtKB/Swiss-Prot
    Q01518
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  6. XM_005270368.1XP_005270425.1  

    See identical proteins and their annotated locations for XP_005270425.1

    UniProtKB/Swiss-Prot
    Q01518
    Related
    ENSP00000361878, OTTHUMP00000004822, ENST00000372792, OTTHUMT00000013111
    Conserved Domains (3) summary
    smart00673
    Location:394431
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4305
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:319474
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  7. XM_011540513.1XP_011538815.1  

    See identical proteins and their annotated locations for XP_011538815.1

    UniProtKB/Swiss-Prot
    Q01518
    Related
    ENSP00000361888, OTTHUMP00000004823, ENST00000372802, OTTHUMT00000013112
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  8. XM_011540511.1XP_011538813.1  

    See identical proteins and their annotated locations for XP_011538813.1

    UniProtKB/Swiss-Prot
    Q01518
    Related
    ENSP00000361884, OTTHUMP00000004825, ENST00000372798, OTTHUMT00000013114
    Conserved Domains (3) summary
    smart00673
    Location:393430
    CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product
    pfam01213
    Location:4304
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318473
    CAP_C; Adenylate cyclase associated (CAP) C terminal

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    40621882..40653922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)