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Mbtps2 membrane bound transcription factor peptidase, site 2 [ Fukomys damarensis (Damara mole-rat) ]

Gene ID: 104850281, updated on 12-Mar-2024

Summary

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Gene symbol
Mbtps2
Gene description
membrane bound transcription factor peptidase, site 2
Locus tag
H920_16257
See related
Ensembl:ENSFDAG00000006833
Gene type
protein coding
RefSeq status
MODEL
Organism
Fukomys damarensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Fukomys
Orthologs
human mouse all
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Genomic context

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See Mbtps2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
102 current DMR_v1.0_HiC (GCF_012274545.1) Unplaced Scaffold NW_022900951.1 (17699529..17739189)
101 previous assembly DMR_v1.0 (GCF_000743615.1) Unplaced Scaffold NW_011046696.1 (1336624..1376155)

NW_022900951.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 34 Neighboring gene small muscle protein X-linked Neighboring gene archaemetzincin-2-like Neighboring gene YY2 transcription factor Neighboring gene spermine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane protein intracellular domain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
membrane-bound transcription factor site-2 protease
Names
Membrane-bound transcription factor site-2 protease
Transcription factor YY2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Fukomys damarensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference DMR_v1.0_HiC Primary Assembly

Genomic

  1. NW_022900951.1 Reference DMR_v1.0_HiC Primary Assembly

    Range
    17699529..17739189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010607130.2 → XP_010605432.1  membrane-bound transcription factor site-2 protease isoform X1

    Related
    ENSFDAP00000012734.1
    Conserved Domains (3) summary
    cd05709
    Location:417 → 506
    S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
    cd06162
    Location:6 → 227
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    cl00117
    Location:253 → 297
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

  2. XM_010607131.3 → XP_010605433.1  membrane-bound transcription factor site-2 protease isoform X2

    Conserved Domains (2) summary
    cd06162
    Location:6 → 227
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    cl00117
    Location:253 → 297
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
Nucleotide Protein
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