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    CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 [ Homo sapiens ]

    Gene ID: 1048, updated on 11-May-2012
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    Summary

    Official Symbol
    CEACAM5provided by HGNC
    Official Full Name
    carcinoembryonic antigen-related cell adhesion molecule 5provided by HGNC
    Primary source
    HGNC:1817
    See related
    Ensembl:ENSG00000105388; HPRD:00274; MIM:114890; Vega:OTTHUMG00000151061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEA; CD66e; DKFZp781M2392
    Summary
    Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
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    Genomic context

    Location :
    19q13.1-q13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (42212530..42234437)
    See CEACAM5 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 4 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 7 Neighboring gene uncharacterized LOC100505535 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) pseudogene Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. No correlation between pretreatment serum CEA levels and tumor volume in locally advanced rectal cancer patients. Kim YJ, et al. Clin Chim Acta, 2012 Feb 18. PMID 22137981.
    2. Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study. Al-Shuneigat JM, et al. J Biomed Sci, 2011 Jul 25. PMID 21787404.
    3. Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients. Raeisossadati R, et al. Int J Colorectal Dis, 2011 Oct. PMID 21573768.
    4. Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer. Lin JK, et al. Int J Colorectal Dis, 2011 Sep. PMID 21538056.
    5. Tissue carcinoembryonic antigen, calcium, copper and iron levels in cancerous lung patients. Alwahaibi NY, et al. Zhongguo Fei Ai Za Zhi, 2011 Jan. PMID 21219828.

    See all (86) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a positive correlation between CEA levels and survival
      Title: No correlation between pretreatment serum CEA levels and tumor volume in locally advanced rectal cancer patients.
    2. the prognostic value of preoperative serum carbohydrate antigen19-9, carcinoembryonic antigen, and carbohydrate antigen 125 for overall survival in patients with colorectal cancer was studied
      Title: Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer.
    3. The copy number of CEA and TEM-8 mRNA, as detected by a real-time quantitative PCR, appears to be a promising marker for evaluating the risk of tumor spread.
      Title: Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients.
    4. Early postoperative CEA concentration is an independent prognostic factor for colorectal cancer.
      Title: Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer.
    5. The levels of CEA and CA19-9 showed no significant increase in colorectal carcinoma.
      Title: Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and ca 19-9 as apoptotic markers; a comparative study.
    6. Stduies indicate that CEA was selectively enriched by a factor of 600-800.
      Title: Tandem affinity depletion: a combination of affinity fractionation and immunoaffinity depletion allows the detection of low-abundance components in the complex proteomes of body fluids.
    7. 93.7% of lung cancer sections showed expression of CEA.
      Title: Tissue carcinoembryonic antigen, calcium, copper and iron levels in cancerous lung patients.
    8. Decreased serum carcinoembryonic antigen is associated with chemoradiation therapy in rectal cancer.
      Title: Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer.
    9. study shows CEA-binding bacteria colonized urogenital tract of CEA transgenic mice but not wild-type by suppressing exfoliation of mucosal cells;CEA binding triggered expression of CD105, changing focal adhesion composition and activating beta1 integrins
      Title: Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation.
    10. The histological types of breast cancer are not significantly related to elevated serum levels of CEA and/or CA 15-3.
      Title: The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type.
    Submit: New GeneRIF Correction See all (65)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P06731 Q01844 EWSR1    HPRD  PubMed  
    P06731 P52272 HNRNPM    HPRD  PubMed  
    P06731 Patched domain containing 2 PTCHD2    HPRD  PubMed  
    BioGRID:107478 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:107478 BioGRID:250540 Hnrnpm    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    anchored to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 5
    Names
    carcinoembryonic antigen-related cell adhesion molecule 5
    meconium antigen 100
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004363.2 → NP_004354.2  carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC008999, M15042
      Consensus CDS
      CCDS12584.1
      UniProtKB/Swiss-Prot
      P06731
      Related
      ENSP00000221992, OTTHUMP00000199032, ENST00000221992, OTTHUMT00000321132
      Conserved Domains (5) summary
      cd00096
      Location:433 – 491
      Blast Score: 112
      Ig; Immunoglobulin domain
      cd05740
      Location:324 – 412
      Blast Score: 317
      Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd05774
      Location:36 – 140
      Blast Score: 417
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      pfam07686
      Location:36 – 140
      Blast Score: 160
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:513 – 590
      Blast Score: 253
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      42212530..42234437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      38644424..38666346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008999.7 (3880..25787) None
    genomic CH471126.1 EAW57059.1
      EAW57060.1
    genomic CQ800159.1 CAG27582.1
    genomic M17303.1 AAB59513.1
    genomic M59255.1 AAA62835.1
    genomic M59710.1 None
    genomic M60964.1 AAA51964.1
    genomic X62151.1 CAA44076.1
    mRNA AK223101.1 BAD96821.1
    mRNA AK310844.1 None
    mRNA BC034671.1 AAH34671.1
    mRNA CR749337.1 CAH18191.1
    mRNA M15042.1 AAA51963.1
    mRNA M16234.1 AAA51972.1
    mRNA M17191.1 AAA51968.1
    mRNA M29540.1 AAA51967.1
    mRNA X16455.1 CAA34474.1
    other-genetic DQ890840.2 ABM81766.1
    other-genetic DQ896753.2 ABM87752.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06731.3 GenPept UniProtKB/Swiss-Prot:P06731
    P78448 GenPept UniProtKB/TrEMBL:P78448
    Q13984 GenPept UniProtKB/TrEMBL:Q13984
    Q53G30 GenPept UniProtKB/TrEMBL:Q53G30
    Q68DM9 GenPept UniProtKB/TrEMBL:Q68DM9
    Q7KZ28 GenPept UniProtKB/TrEMBL:Q7KZ28
    Q8N4D0 GenPept UniProtKB/TrEMBL:Q8N4D0
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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