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TADA3 transcriptional adaptor 3 [ Homo sapiens (human) ]

Gene ID: 10474, updated on 26-May-2016
Official Symbol
TADA3provided by HGNC
Official Full Name
transcriptional adaptor 3provided by HGNC
Primary source
HGNC:HGNC:19422
See related
Ensembl:ENSG00000171148 HPRD:04252; MIM:602945; Vega:OTTHUMG00000128440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA3; NGG1; hADA3; STAF54; TADA3L
Summary
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Orthologs
Location:
3p25.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (9779964..9793011, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9821648..9834695, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridylate synthase domain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20221, FLJ21329

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
intracellular estrogen receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
regulation of tubulin deacetylation IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcriptional adapter 3
Names
ADA3 homolog
ADA3-like protein
alteration/deficiency in activation 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278270.1NP_001265199.1  transcriptional adapter 3 isoform a

    See identical proteins and their annotated locations for NP_001265199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AA602644, AK292264, BC009240, BC013433
    Consensus CDS
    CCDS2583.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A8K899
    Related
    ENSP00000393471, OTTHUMP00000207467, ENST00000440161, OTTHUMT00000338857
    Conserved Domains (1) summary
    pfam10198
    Location:309431
    Ada3; Histone acetyltransferases subunit 3
  2. NM_006354.3NP_006345.1  transcriptional adapter 3 isoform a

    See identical proteins and their annotated locations for NP_006345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AA602644, AC022382, AK292264, BC009240, BC013433, BM560517, DB032623
    Consensus CDS
    CCDS2583.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A8K899
    Related
    ENSP00000307684, OTTHUMP00000158554, ENST00000301964, OTTHUMT00000250236
    Conserved Domains (1) summary
    pfam10198
    Location:309431
    Ada3; Histone acetyltransferases subunit 3
  3. NM_133480.2NP_597814.1  transcriptional adapter 3 isoform b

    See identical proteins and their annotated locations for NP_597814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1, that results in an early stop codon and a different 3' UTR, compared to variant 1. It encodes isoform b which is shorter at the C-terminus, compared to isoform a.
    Source sequence(s)
    AC022382, AK292264, BC009240, BM560517, DB032623
    Consensus CDS
    CCDS2584.1
    UniProtKB/Swiss-Prot
    O75528
    UniProtKB/TrEMBL
    A0A024R2D7, A8K899
    Related
    ENSP00000343649, OTTHUMP00000158555, ENST00000343450, OTTHUMT00000250237
    Conserved Domains (1) summary
    pfam10198
    Location:309369
    Ada3; Histone acetyltransferases subunit 3

RNA

  1. NR_103488.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons and uses alternate splice sites in the 5' terminal exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA602644, AC022382, AK292264, BC013433, BG477633

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    9779964..9793011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712930.2XP_006712993.1  

    See identical proteins and their annotated locations for XP_006712993.1

    Conserved Domains (1) summary
    pfam10198
    Location:300369
    Ada3; Histone acetyltransferases subunit 3

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    9771842..9784887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133481.1: Suppressed sequence

    Description
    NM_133481.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.