HMGN4 high mobility group nucleosomal binding domain 4 [Homo sapiens] - Gene

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Summary

Official Symbol: HMGN4provided by HGNC
Official Full Name: high mobility group nucleosomal binding domain 4provided by HGNC
Primary source: HGNC:4989
See related: Ensembl:ENSG00000182952; HPRD:17111; Vega:OTTHUMG00000014458
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NHC; HMG17L3; MGC5145
Summary: The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6p21.3

Sequence :: Chromosome: 6; NC_000006.11 (26538572..26547165)

See HMGN4 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:115736	BioGRID:108431	EWSR1		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromatin	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: high mobility group nucleosome-binding domain-containing protein 4

Names: high mobility group nucleosome-binding domain-containing protein 4; high mobility group protein N4; high-mobility group protein 17-like 3; non-histone chromosomal protein HMG-17-like 3; high-mobility group (nonhistone chromosomal) protein 17-like 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006353.2 → NP_006344.1 high mobility group nucleosome-binding domain-containing protein 4

Status: REVIEWED

Source sequence(s)

AU143224, BC001282

Consensus CDS

CCDS4615.1

UniProtKB/Swiss-Prot

O00479

Related

ENSP00000327691, ENST00000328219

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

26538572..26547165

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

26481618..26490233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121936.17	CAC16803.1
genomic	CH471087.1	EAW55586.1
		EAW55587.1
		EAW55588.1
		EAW55589.1
		EAW55590.1
mRNA	AK311841.1	BAG34783.1
mRNA	AU143224.1	None
mRNA	BC001282.1	AAH01282.1
mRNA	BC035998.1	None
mRNA	BT009824.1	AAP88826.1
mRNA	U90549.1	AAB53427.1
other-genetic	HQ257976.1	ADR82730.1