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TACC3 transforming acidic coiled-coil containing protein 3 [ Homo sapiens (human) ]

Gene ID: 10460, updated on 15-May-2016
Official Symbol
TACC3provided by HGNC
Official Full Name
transforming acidic coiled-coil containing protein 3provided by HGNC
Primary source
HGNC:HGNC:11524
See related
Ensembl:ENSG00000013810 HPRD:05601; MIM:605303; Vega:OTTHUMG00000089535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERIC1; ERIC-1
Summary
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Orthologs
Location:
4p16.3
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (1721490..1745178)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1723217..1746905)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stem-loop binding protein Neighboring gene transmembrane protein 129 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
NHGRI GWA Catalog
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog
  • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora A signaling, organism-specific biosystem
    Aurora A signaling
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117382, MGC133242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
transforming acidic coiled-coil-containing protein 3
Names
transforming, acidic coiled-coil containing protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006342.2NP_006333.1  transforming acidic coiled-coil-containing protein 3

    See identical proteins and their annotated locations for NP_006333.1

    Status: REVIEWED

    Source sequence(s)
    AA682436, AC016773, AF093543, AI684124, DB098941
    Consensus CDS
    CCDS3352.1
    UniProtKB/Swiss-Prot
    Q9Y6A5
    Related
    ENSP00000326550, OTTHUMP00000113796, ENST00000313288, OTTHUMT00000203730
    Conserved Domains (2) summary
    pfam05010
    Location:638837
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl21485
    Location:687788
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    1721490..1745178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247929.1XP_005247986.1  

    Conserved Domains (2) summary
    pfam05010
    Location:638841
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    cl21485
    Location:691792
    OmpH; Outer membrane protein (OmpH-like)
  2. XM_011513386.1XP_011511688.1  

    Conserved Domains (2) summary
    PRK12323
    Location:239482
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
    pfam05010
    Location:638691
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. XM_011513387.1XP_011511689.1  

    Conserved Domains (1) summary
    PRK12323
    Location:239482
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
  4. XM_005247930.1XP_005247987.1  

    Conserved Domains (1) summary
    pfam05010
    Location:278481
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    1721189..1744883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)