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PPIE peptidylprolyl isomerase E [ Homo sapiens (human) ]

Gene ID: 10450, updated on 8-May-2016
Official Symbol
PPIEprovided by HGNC
Official Full Name
peptidylprolyl isomerase Eprovided by HGNC
Primary source
HGNC:HGNC:9258
See related
Ensembl:ENSG00000084072 HPRD:03893; MIM:602435; Vega:OTTHUMG00000009248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP33; CYP-33
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Orthologs
Location:
1p32
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (39738845..39763914)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40204517..40229586)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hippocalcin like 4 Neighboring gene coiled-coil domain containing 25 pseudogene Neighboring gene bone morphogenetic protein 8b Neighboring gene uncharacterized LOC105378666 Neighboring gene 3-oxoacid CoA-transferase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular peptidylprolyl isomerase E protein (PPIE, cyclophilin E) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Dual incision in TC-NER, organism-specific biosystem (from REACTOME)
    Dual incision in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), the oligonucleotide that contains the lesion is excised from the open bubbl...
  • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
    Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
  • Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
    Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemIn transcription-coupled nucleotide excision repair (TC-NER), similar to global genome nucleotide excision repair (GG-NER), DNA polymerases delta or epsilon, or the Y family DNA polymerase kappa, fil...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
    Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
  • Spliceosome, 35S U5-snRNP, conserved biosystem (from KEGG)
    Spliceosome, 35S U5-snRNP, conserved biosystemStructural complex; Genetic information processing; Spliceosome
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
    Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3736, MGC111222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
cyclosporin A binding TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peptidyl-prolyl cis-trans isomerase E
Names
PPIase E
cyclophilin-33
peptidylprolyl isomerase E (cyclophilin E)
rotamase E
NP_001181936.1
NP_006103.1
NP_982281.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_044984.2 RefSeqGene

    Range
    51664..76733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195007.1NP_001181936.1  peptidyl-prolyl cis-trans isomerase E isoform 4

    See identical proteins and their annotated locations for NP_001181936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL049824, BU689929, DA079924, DQ160195
    Consensus CDS
    CCDS53299.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000361918, OTTHUMP00000010839, ENST00000372830, OTTHUMT00000025644
    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:140279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  2. NM_001319293.1NP_001306222.1  peptidyl-prolyl cis-trans isomerase E isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CA445146, CT002466, DA079924
    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:129268
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  3. NM_006112.3NP_006103.1  peptidyl-prolyl cis-trans isomerase E isoform 1

    See identical proteins and their annotated locations for NP_006103.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AL049824, BC004898, CK300365, DA079924
    Consensus CDS
    CCDS443.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000312769, OTTHUMP00000010837, ENST00000324379, OTTHUMT00000025642
    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:140298
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  4. NM_203456.2NP_982281.1  peptidyl-prolyl cis-trans isomerase E isoform 2

    See identical proteins and their annotated locations for NP_982281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon and thereby differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AF042386, BU689929, DA079924
    Consensus CDS
    CCDS442.1
    UniProtKB/Swiss-Prot
    Q9UNP9
    Related
    ENSP00000348904, OTTHUMP00000010838, ENST00000356511, OTTHUMT00000025643
    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:140281
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

RNA

  1. NR_036543.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-most exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL049824, BU160972, CK300365, DA079924
  2. NR_036544.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites in the 5'-most exon and in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK304694, AL049824, CK300365, DA079924

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    39738845..39763914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540501.1XP_011538803.1  

    Conserved Domains (1) summary
    cl00197
    Location:56195
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  2. XM_006710289.1XP_006710352.1  

    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
    cl00197
    Location:129266
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
  3. XM_006710291.1XP_006710354.1  

    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:129268
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  4. XM_006710292.2XP_006710355.1  

    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:140279
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
  5. XM_006710290.2XP_006710353.1  

    See identical proteins and their annotated locations for XP_006710353.1

    Conserved Domains (3) summary
    smart00360
    Location:779
    RRM; RNA recognition motif
    cd01926
    Location:129285
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd12347
    Location:880
    RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

RNA

  1. XR_946520.1 RNA Sequence

  2. XR_946521.1 RNA Sequence

  3. XR_946519.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    40319960..40345027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203457.1: Suppressed sequence

    Description
    NM_203457.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.