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ZER1 zyg-11 related cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 10444, updated on 26-May-2016
Official Symbol
ZER1provided by HGNC
Official Full Name
zyg-11 related cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:30960
See related
Ensembl:ENSG00000160445 HPRD:10802; Vega:OTTHUMG00000020759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZYG; C9orf60; ZYG11BL
Summary
This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Orthologs
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (128729786..128772422, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131492065..131534220, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376287 Neighboring gene SET nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene uncharacterized LOC100506100 Neighboring gene zinc finger DHHC-type containing 12 Neighboring gene uncharacterized LOC105376288 Neighboring gene TBC1 domain family member 13 Neighboring gene chromosome 9 open reading frame 114 Neighboring gene endonuclease G

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • RP11-545E17.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein zer-1 homolog
Names
ZYG homolog
zer-1 homolog
zyg-11 homolog B-like protein
zyg-11 related, cell cycle regulator

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006336.3NP_006327.2  protein zer-1 homolog

    See identical proteins and their annotated locations for NP_006327.2

    Status: REVIEWED

    Source sequence(s)
    BC052563, HY170548
    Consensus CDS
    CCDS6910.1
    UniProtKB/Swiss-Prot
    Q7Z7L7
    UniProtKB/TrEMBL
    A0A024R8B0
    Related
    ENSP00000291900, OTTHUMP00000022294, ENST00000291900, OTTHUMT00000054491
    Conserved Domains (3) summary
    cd00020
    Location:516642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    128729786..128772422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518122.1XP_011516424.1  

    See identical proteins and their annotated locations for XP_011516424.1

    UniProtKB/Swiss-Prot
    Q7Z7L7
    UniProtKB/TrEMBL
    A0A024R8B0
    Conserved Domains (3) summary
    cd00020
    Location:516642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. XM_005251645.1XP_005251702.1  

    See identical proteins and their annotated locations for XP_005251702.1

    UniProtKB/Swiss-Prot
    Q7Z7L7
    UniProtKB/TrEMBL
    A0A024R8B0
    Conserved Domains (3) summary
    cd00020
    Location:516642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_005251646.2XP_005251703.1  

    Conserved Domains (3) summary
    cd00020
    Location:514640
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82104
    LRR_AMN1; leucine-rich repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    131643031..131685172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)