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C1D C1D nuclear receptor corepressor [ Homo sapiens (human) ]

Gene ID: 10438, updated on 26-May-2016
Official Symbol
C1Dprovided by HGNC
Official Full Name
C1D nuclear receptor corepressorprovided by HGNC
Primary source
HGNC:HGNC:29911
See related
Ensembl:ENSG00000197223 HPRD:07382; MIM:606997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR
Summary
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Orthologs
Location:
2p13-p12
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (68042200..68063027, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68269332..68290159, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927701 Neighboring gene F-box and leucine-rich repeat protein 12 pseudogene Neighboring gene uncharacterized LOC105374789 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of C1D nuclear receptor corepressor (C1D) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC12261, MGC14659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ligand-dependent nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear exosome (RNase complex) TAS
Traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nuclear nucleic acid-binding protein C1D
Names
C1D DNA-binding protein
C1D nuclear receptor co-repressor
nuclear DNA-binding protein
small unique nuclear receptor co-repressor
small unique nuclear receptor corepressor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190263.1NP_001177192.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_001177192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, AI004680, AK290451, BG505686
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000386779, OTTHUMP00000202688, ENST00000409302, OTTHUMT00000328527
    Conserved Domains (1) summary
    pfam04000
    Location:1796
    Sas10_Utp3; Sas10/Utp3/C1D family
  2. NM_001190265.1NP_001177194.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_001177194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC079112, AI004680, BG505686, DA900336
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Conserved Domains (1) summary
    pfam04000
    Location:1796
    Sas10_Utp3; Sas10/Utp3/C1D family
  3. NM_006333.3NP_006324.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_006324.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript represents variant (1). Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC016284, BG505686, BM354091, CN342947
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000348107, OTTHUMP00000159964, ENST00000355848, OTTHUMT00000251757
    Conserved Domains (1) summary
    pfam04000
    Location:1796
    Sas10_Utp3; Sas10/Utp3/C1D family
  4. NM_173177.2NP_775269.1  nuclear nucleic acid-binding protein C1D

    See identical proteins and their annotated locations for NP_775269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC009589, BG505686, BM354091, CN342947
    Consensus CDS
    CCDS1883.1
    UniProtKB/Swiss-Prot
    Q13901
    Related
    ENSP00000386468, OTTHUMP00000202687, ENST00000410067, OTTHUMT00000328526
    Conserved Domains (1) summary
    pfam04000
    Location:1796
    Sas10_Utp3; Sas10/Utp3/C1D family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    68042200..68063027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    68200196..68221015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)