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TOP2A DNA topoisomerase II alpha [ Charadrius vociferus (killdeer) ]

Gene ID: 104290072, updated on 12-Mar-2024

Summary

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Gene symbol
TOP2A
Gene description
DNA topoisomerase II alpha
Gene type
protein coding
RefSeq status
MODEL
Organism
Charadrius vociferus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Charadrius
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
46
Annotation release Status Assembly Chr Location
100 current ASM70802v2 (GCF_000708025.1) Unplaced Scaffold NW_009649298.1 (3077..27345, complement)

NW_009649298.1Genomic Context describing neighboring genes Neighboring gene tensin 4 Neighboring gene C-C motif chemokine receptor 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_009649298.1 Unplaced Scaffold Reference ASM70802v2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in resolution of meiotic recombination intermediates IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 2-alpha
Names
topoisomerase (DNA) II alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Charadrius vociferus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM70802v2

Genomic

  1. NW_009649298.1 Reference ASM70802v2

    Range
    3077..27345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009889120.1 → XP_009887422.1  DNA topoisomerase 2-alpha

    Conserved Domains (9) summary
    cd03365
    Location:767 → 887
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    pfam01391
    Location:3 → 81
    Collagen; Collagen triple helix repeat (20 copies)
    cd00187
    Location:1023 → 1476
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:577 → 729
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:337 → 1694
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:392 → 489
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam08070
    Location:1771 → 1857
    DTHCT; DTHCT (NUC029) region
    pfam16898
    Location:885 → 1023
    TOPRIM_C; C-terminal associated domain of TOPRIM
    cl23985
    Location:215 → 321
    Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
Nucleotide Protein
Heading Accession and Version

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