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ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 10425, updated on 8-May-2016
Official Symbol
ARIH2provided by HGNC
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:690
See related
Ensembl:ENSG00000177479 HPRD:09286; MIM:605615; Vega:OTTHUMG00000133547
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARI2; TRIAD1
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Orthologs
Location:
3p21
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (48918821..48985541)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956265..49022974)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ariadne homolog 2 opposite strand Neighboring gene uncharacterized LOC105377080 Neighboring gene uncharacterized LOC105377079 Neighboring gene uncharacterized LOC101928814 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10938, FLJ33921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
E3 ubiquitin-protein ligase ARIH2
Names
all-trans retinoic acid inducible RING finger
ariadne homolog 2
protein ariadne-2 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317333.1NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC134028, AC137630, AK223550, AL110187, BG476221
    UniProtKB/Swiss-Prot
    O95376
    UniProtKB/TrEMBL
    Q53ET9, Q6IBL8
    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298335
    IBR; IBR domain
  2. NM_001317334.1NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221, BM928477
    UniProtKB/Swiss-Prot
    O95376
    Conserved Domains (2) summary
    smart00647
    Location:66128
    IBR; In Between Ring fingers
    pfam01485
    Location:156193
    IBR; IBR domain
  3. NM_006321.3NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    See identical proteins and their annotated locations for NP_006312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376
    UniProtKB/TrEMBL
    Q6IBL8
    Related
    ENSP00000348769, OTTHUMP00000164828, ENST00000356401, OTTHUMT00000257525
    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298335
    IBR; IBR domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    48918821..48985541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533268.1XP_011531570.1  

    See identical proteins and their annotated locations for XP_011531570.1

    Conserved Domains (1) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
  2. XM_011533266.1XP_011531568.1  

    See identical proteins and their annotated locations for XP_011531568.1

    Conserved Domains (1) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
  3. XM_005264798.1XP_005264855.1  

    Related
    ENSP00000403222, OTTHUMP00000210388, ENST00000449376, OTTHUMT00000345248
    Conserved Domains (2) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
    pfam01485
    Location:298335
    IBR; IBR domain
  4. XM_011533265.1XP_011531567.1  

    See identical proteins and their annotated locations for XP_011531567.1

    Conserved Domains (1) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
  5. XM_011533267.1XP_011531569.1  

    See identical proteins and their annotated locations for XP_011531569.1

    Conserved Domains (1) summary
    smart00647
    Location:208270
    IBR; In Between Ring fingers
  6. XM_011533271.1XP_011531573.1  

    See identical proteins and their annotated locations for XP_011531573.1

    Conserved Domains (1) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
  7. XM_011533273.1XP_011531575.1  

    See identical proteins and their annotated locations for XP_011531575.1

    Conserved Domains (1) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
  8. XM_011533270.1XP_011531572.1  

    See identical proteins and their annotated locations for XP_011531572.1

    Conserved Domains (1) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
  9. XM_011533275.1XP_011531577.1  

    See identical proteins and their annotated locations for XP_011531577.1

    Conserved Domains (2) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
    pfam01485
    Location:226263
    IBR; IBR domain
  10. XM_011533274.1XP_011531576.1  

    See identical proteins and their annotated locations for XP_011531576.1

    Conserved Domains (1) summary
    smart00647
    Location:124186
    IBR; In Between Ring fingers
  11. XM_011533272.1XP_011531574.1  

    See identical proteins and their annotated locations for XP_011531574.1

    Conserved Domains (1) summary
    smart00647
    Location:136198
    IBR; In Between Ring fingers
  12. XM_011533269.1XP_011531571.1  

    Conserved Domains (1) summary
    smart00647
    Location:181243
    IBR; In Between Ring fingers
  13. XM_011533276.1XP_011531578.1  

RNA

  1. XR_940362.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    48908394..48975548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)