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TESK2 testis-specific kinase 2 [ Homo sapiens (human) ]

Gene ID: 10420, updated on 8-May-2016
Official Symbol
TESK2provided by HGNC
Official Full Name
testis-specific kinase 2provided by HGNC
Primary source
HGNC:HGNC:11732
See related
Ensembl:ENSG00000070759 MIM:604746; Vega:OTTHUMG00000007680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Orthologs
Location:
1p32
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (45343883..45491342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45809555..45956840, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene 4-hydroxyphenylpyruvate dioxygenase like Neighboring gene mutY DNA glycosylase Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene uncharacterized LOC105378692 Neighboring gene coiled-coil domain containing 163, pseudogene Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
dual specificity testis-specific protein kinase 2
Names
testicular protein kinase 2
NP_009101.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320800.1NP_001307729.1  dual specificity testis-specific protein kinase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB057597, AK294172, AL451136, BC022194, CD367940
    UniProtKB/Swiss-Prot
    Q96S53
    UniProtKB/TrEMBL
    B4DFN2
    Conserved Domains (1) summary
    cd14155
    Location:1233
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
  2. NM_007170.2NP_009101.2  dual specificity testis-specific protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_009101.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB057597, BC033085, DA990759, DB161528
    Consensus CDS
    CCDS41323.1
    UniProtKB/Swiss-Prot
    Q96S53
    Related
    ENSP00000361158, OTTHUMP00000009093, ENST00000372086, OTTHUMT00000020523
    Conserved Domains (2) summary
    smart00219
    Location:62309
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    45343883..45491342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540498.1XP_011538800.1  

    Conserved Domains (1) summary
    cd14155
    Location:1233
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
  2. XM_011540497.1XP_011538799.1  

    See identical proteins and their annotated locations for XP_011538799.1

    UniProtKB/Swiss-Prot
    Q96S53
    Conserved Domains (2) summary
    smart00219
    Location:62309
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
  3. XM_006710287.2XP_006710350.1  

    See identical proteins and their annotated locations for XP_006710350.1

    UniProtKB/Swiss-Prot
    Q96S53
    Conserved Domains (2) summary
    smart00219
    Location:62309
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64316
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
  4. XM_005270355.2XP_005270412.1  

    Conserved Domains (2) summary
    smart00220
    Location:62258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:64267
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011540499.1XP_011538801.1  

    See identical proteins and their annotated locations for XP_011538801.1

    UniProtKB/TrEMBL
    D3DPZ7
    Conserved Domains (1) summary
    cl21453
    Location:1108
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011540500.1XP_011538802.1  

    Conserved Domains (2) summary
    smart00219
    Location:62293
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:64293
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    45926358..46073590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)