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    YAP1 Yes-associated protein 1 [ Homo sapiens ]

    Gene ID: 10413, updated on 12-Feb-2012
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    Summary

    Official Symbol
    YAP1provided by HGNC
    Official Full Name
    Yes-associated protein 1provided by HGNC
    Primary source
    HGNC:16262
    See related
    Ensembl:ENSG00000137693; HPRD:09424; MIM:606608; Vega:OTTHUMG00000167322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YAP; YKI; YAP2; YAP65
    Summary
    This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (101981192..102104154)
    See YAP1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene KIAA1377 Neighboring gene proline rich 21 pseudogene Neighboring gene chromosome 11 open reading frame 70 Neighboring gene ribosomal protein S6 pseudogene 17 Neighboring gene baculoviral IAP repeat containing 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors. McDonald CB, et al. Biochemistry, 2011 Nov 8. PMID 21981024.
    2. PP1A-mediated dephosphorylation positively regulates YAP2 activity. Wang P, et al. PLoS One, 2011. PMID 21909427.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Nishikawa E, et al. Cancer Res, 2011 Oct 1. PMID 21856745.
    5. Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation. Urtasun R, et al. Hepatology, 2011 Dec. PMID 21800344.

    See all (88) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Expression of CTGF can be stimulated through the EGFR-signaling system in HCC cells in a novel cross-talk with the oncoprotein YAP
      Title: Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation.
    2. These findings define a novel molecular mechanism that YAP2 is positively regulated by PP1-mediated dephosphorylation in the cell survival.
      Title: PP1A-mediated dephosphorylation positively regulates YAP2 activity.
    3. The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP1 and WBP2 in a highly promiscuous and subtle manner.
      Title: Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
    4. the transcriptional coactivator YAP1 was determined to be a direct target of miR-375 in lung cancer cells
      Title: miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.
    5. study shows that YAP could promote cell proliferation by activating transcription factor Fra-1 in oral squamous cell carcinoma.
      Title: Yes-associated protein promotes cell proliferation by activating Fos Related Activator-1 in oral squamous cell carcinoma.
    6. Data suggest that YAP1 could be a prognostic biomarker and potential therapeutic target for gastric cancer.
      Title: Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis.
    7. alphaE-catenin as a tumor suppressor that inhibits Yap1 activity and sequesters it in the cytoplasm.
      Title: α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1.
    8. findings suggest that YAP derepression contributes to the genesis of ovarian clear cell carcinoma and that the SWH pathway is an attractive therapeutic target
      Title: The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.
    9. This study demonistrated taht the YAP1 overexpression promotes growth of glioblastoma cell lines in vitro.
      Title: Yes-associated protein 1 is widely expressed in human brain tumors and promotes glioblastoma growth.
    10. JNK1 and JNK2 were identified as robust YAP kinases.
      Title: JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.
    Submit: New GeneRIF Correction See all (62)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006097.1 NP_006154.1 NFE2    BIND  PubMed p45 interacts with hYAP. 
    NP_006097.1 NP_005418.1 TP73    BIND  PubMed p73-alpha interacts with YAP. 
    P46937 P00519 ABL1    HPRD  PubMed  
    P46937 P31749 AKT1    HPRD  PubMed  
    P46937 Q15303 ERBB4    HPRD  PubMed  
    P46937 Q00839 HNRNPU    HPRD  PubMed  
    P46937 Q16621 NFE2    HPRD  PubMed  
    P46937 Q01196 RUNX1    HPRD  PubMed  
    P46937 Q13950 RUNX2    HPRD  PubMed  
    P46937 O14745 SLC9A3R1    HPRD  PubMed  
    P46937 O15105 SMAD7    HPRD  PubMed  
    P46937 P28347 TEAD1    HPRD  PubMed  
    P46937 Q15562 TEAD2    HPRD  PubMed  
    P46937 Q99594 TEAD3    HPRD  PubMed  
    P46937 Q15561 TEAD4    HPRD  PubMed  
    P46937 Q13625 TP53BP2    HPRD  PubMed  
    P46937 O15350 TP73    HPRD  PubMed  
    P46937 Q96G27 WBP1    HPRD  PubMed  
    P46937 Q969T9 WBP2    HPRD  PubMed  
    P46937 P61981 YWHAG    HPRD  PubMed  
    P46937 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:115684 BioGRID:127557 AMOT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115684 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115684 BioGRID:116562 DENND3    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:108347 EP300    BioGRID  PubMed Co-localization 
    BioGRID:115684 BioGRID:108378 ERBB4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115684 BioGRID:116887 FBXW11    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115684 BioGRID:109999 KIF5A    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:107309 RUNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:107308 RUNX2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115684 BioGRID:107312 RUNX3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115684 BioGRID:115378 SCAMP3    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:114769 SLC9A3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115684 BioGRID:110266 SMAD6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115684 BioGRID:110267 SMAD7    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid 
    BioGRID:115684 BioGRID:201280 Smad7    BioGRID  PubMed Two-hybrid 
    BioGRID:115684 BioGRID:113012 TP53BP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:115684 BioGRID:114181 TP63    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115684 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115684 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115684 BioGRID:117103 WBP1    BioGRID  PubMed Protein-peptide 
    BioGRID:115684 BioGRID:204545 Wbp1    BioGRID  PubMed Protein-peptide; Reconstituted Complex 
    BioGRID:115684 BioGRID:204546 Wbp2    BioGRID  PubMed Protein-peptide 
    BioGRID:115684 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115684 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB4 signaling events, organism-specific biosystem
      ErbB4 signaling events
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contact inhibition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hippo signaling cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    yorkie homolog
    Names
    yorkie homolog
    yes-associated protein 2
    yes-associated protein beta
    yes-associated protein delta
    65 kDa Yes-associated protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029530.1 RefSeqGene

      Range
      5001..127963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130145.2 → NP_001123617.1  yorkie homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, BC038235
      Consensus CDS
      CCDS44716.1
      UniProtKB/TrEMBL
      E3WEB6
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000282441, OTTHUMP00000235695, ENST00000282441, OTTHUMT00000394151
      Conserved Domains (1) summary
      cd00201
      Location:233 – 262
      Blast Score: 120
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. NM_001195044.1 → NP_001181973.1  yorkie homolog isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, AY316529
      Consensus CDS
      CCDS53699.1
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000431574, OTTHUMP00000235696, ENST00000531439, OTTHUMT00000394152
      Conserved Domains (1) summary
      cd00201
      Location:233 – 262
      Blast Score: 119
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    3. NM_001195045.1 → NP_001181974.1  yorkie homolog isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AA854862, AI128142, AK316116, AL832620, AP000942, BC038235
      Consensus CDS
      CCDS53700.1
      UniProtKB/TrEMBL
      B4DTY1
      UniProtKB/TrEMBL
      B7ZA01
      UniProtKB/Swiss-Prot
      P46937
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000435602, OTTHUMP00000235697, ENST00000524575, OTTHUMT00000394153
      Conserved Domains (1) summary
      cd00201
      Location:55 – 84
      Blast Score: 120
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    4. NM_006106.4 → NP_006097.2  yorkie homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AI128142, AL832620, AP000942, AP001527, AP002777
      Consensus CDS
      CCDS8314.2
      UniProtKB/TrEMBL
      E9PRV2
      UniProtKB/TrEMBL
      Q86T74
      Related
      ENSP00000434134, OTTHUMP00000235694, ENST00000526343, OTTHUMT00000394150
      Conserved Domains (1) summary
      cd00201
      Location:174 – 203
      Blast Score: 121
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      101981192..102104154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      97907865..98030476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP000942.6 None
    genomic AP001527.5 (88789..120211) None
    genomic AP002777.4 None
    genomic CH471065.1 EAW67011.1
      EAW67012.1
      EAW67013.1
      EAW67014.1
      EAW67015.1
    genomic X80507.1 CAA56672.1
    mRNA AA854862.1 None
    mRNA AB567720.1 BAJ41471.1
    mRNA AB567721.1 BAJ41472.1
    mRNA AI128142.1 None
    mRNA AK300414.1 BAG62143.1
    mRNA AK304485.1 BAG65295.1
    mRNA AK310620.1 None
    mRNA AK316116.1 BAH14487.1
    mRNA AL832620.2 CAD89963.1
    mRNA AY316529.1 AAP92710.1
    mRNA BC026212.2 None
    mRNA BC038235.1 AAH38235.1
    mRNA BU073244.1 None
    mRNA CX780993.1 None
    mRNA DC419625.1 None
    Protein Accession Links
    GenePept Link UniProtKB Link
    P46937.2 GenPept UniProtKB/Swiss-Prot:P46937
    Q86T74 GenPept UniProtKB/TrEMBL:Q86T74
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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