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NSA2 NSA2, ribosome biogenesis homolog [ Homo sapiens (human) ]

Gene ID: 10412, updated on 26-May-2016
Official Symbol
NSA2provided by HGNC
Official Full Name
NSA2, ribosome biogenesis homologprovided by HGNC
Primary source
HGNC:HGNC:30728
See related
Ensembl:ENSG00000164346 HPRD:18191; MIM:612497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCLG1; TINP1; CDK105; HCL-G1; HUSSY29; HUSSY-29
Summary
This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Orthologs
Location:
5q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (74765429..74776912)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74062816..74072737)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ectodermal-neural cortex 1 Neighboring gene hexosaminidase subunit beta Neighboring gene uncharacterized LOC105379038 Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene family with sequence similarity 169 member A Neighboring gene actin related protein 2/3 complex subunit 1A pseudogene Neighboring gene uncharacterized LOC441086

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of NSA2 ribosome biogenesis homolog (S. cerevisiae, NSA2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • YR-29

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ribosome biogenesis protein NSA2 homolog
Names
NSA2 ribosome biogenesis homolog
TGF beta-inducible nuclear protein 1
TGF-beta inducible nuclear protein
TGF-beta-inducible nuclear protein 1
hairy cell leukemia protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271665.1NP_001258594.1  ribosome biogenesis protein NSA2 homolog isoform 2

    See identical proteins and their annotated locations for NP_001258594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA830219, AF372458, CB052084, HY021659
    Consensus CDS
    CCDS75260.1
    UniProtKB/Swiss-Prot
    O95478
    UniProtKB/TrEMBL
    A0A0A0MQZ6
    Related
    ENSP00000296802, ENST00000296802
    Conserved Domains (1) summary
    cl00880
    Location:4174
    Ribosomal_S8e_like; Eukaryotic/archaeal ribosomal protein S8e and similar proteins
  2. NM_014886.4NP_055701.1  ribosome biogenesis protein NSA2 homolog isoform 1

    See identical proteins and their annotated locations for NP_055701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA830219, AJ012409, HY021659
    Consensus CDS
    CCDS4025.1
    UniProtKB/Swiss-Prot
    O95478
    UniProtKB/TrEMBL
    Q5J7U2
    Related
    ENSP00000483484, OTTHUMP00000161947, ENST00000610426, OTTHUMT00000254041
    Conserved Domains (1) summary
    cd11381
    Location:4260
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)

RNA

  1. NR_073403.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830219, AA921837, AF372458, BQ775601, HY021659

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    74765429..74776912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543098.1XP_011541400.1  

    Conserved Domains (1) summary
    cd11381
    Location:15271
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)

RNA

  1. XR_948227.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    73495664..73505590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)