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Acly ATP citrate lyase [ Mus musculus (house mouse) ]

Gene ID: 104112, updated on 8-May-2016
Official Symbol
Aclyprovided by MGI
Official Full Name
ATP citrate lyaseprovided by MGI
Primary source
MGI:MGI:103251
See related
Ensembl:ENSMUSG00000020917 Vega:OTTMUSG00000006279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW538652; A730098H14Rik
Orthologs
Location:
11; 11 D
Exon count:
29
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (100476352..100528000, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100337670..100389215, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene microRNA 7116 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene tetratricopeptide repeat domain 25

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP citrate synthase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cofactor binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-citrate synthase
Names
ATP-citrate (pro-S-)-lyase
citrate cleavage enzyme
NP_001186225.1
NP_598798.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199296.1NP_001186225.1  ATP-citrate synthase isoform 1

    See identical proteins and their annotated locations for NP_001186225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK132755, BE623317, BX842667
    Consensus CDS
    CCDS56807.1
    UniProtKB/TrEMBL
    Q3V117
    Related
    ENSMUSP00000103012, OTTMUSP00000022507, ENSMUST00000107389, OTTMUST00000048853
    Conserved Domains (6) summary
    cd06100
    Location:8561093
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:4891094
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:492601
    CoA_binding; CoA binding domain
    cl17255
    Location:55207
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:660785
    Ligase_CoA; CoA-ligase
  2. NM_134037.3NP_598798.1  ATP-citrate synthase isoform 2

    See identical proteins and their annotated locations for NP_598798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the middle of the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BC056378, BE623317, BX842667
    Consensus CDS
    CCDS25425.1
    UniProtKB/Swiss-Prot
    Q91V92
    Related
    ENSMUSP00000007131, OTTMUSP00000006599, ENSMUST00000007131, OTTMUST00000014210
    Conserved Domains (6) summary
    cd06100
    Location:8461083
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:4791084
    PLN02522; ATP citrate (pro-S)-lyase
    smart00881
    Location:482591
    CoA_binding; CoA binding domain
    cl17255
    Location:55207
    ATP-grasp_4; ATP-grasp domain
    cl22543
    Location:650775
    Ligase_CoA; CoA-ligase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    100476352..100528000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    111095706..111147449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)