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Synj1 synaptojanin 1 [ Mus musculus (house mouse) ]

Gene ID: 104015, updated on 28-May-2016
Official Symbol
Synj1provided by MGI
Official Full Name
synaptojanin 1provided by MGI
Primary source
MGI:MGI:1354961
See related
Ensembl:ENSMUSG00000022973 Vega:OTTMUSG00000027935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA675315; mKIAA0910; A930006D20Rik
Orthologs
Location:
16; 16 C3-C4
Exon count:
36
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (90936092..91012137, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (90936342..91011553, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene RIKEN cDNA 1110004E09 gene Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene predicted gene, 41491 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene RIKEN cDNA 4932438H23 gene Neighboring gene H3 histone, family 3A, pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol phosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol phosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
inositol phosphate dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endosome organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gliogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
clathrin coat TAS
Traceable Author Statement
more info
PubMed 
clathrin coat of coated pit ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane coat IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
presynapse ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
synaptojanin-1
Names
synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1
NP_001038980.1
NP_001157955.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045515.1NP_001038980.1  synaptojanin-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB093272, CJ048086, CJ104552
    Consensus CDS
    CCDS49906.1
    UniProtKB/TrEMBL
    E9Q7S0
    Related
    ENSMUSP00000128997, ENSMUST00000170853
    Conserved Domains (4) summary
    cd09098
    Location:533868
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:911966
    RRM; RNA recognition motif
    cd12719
    Location:893969
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:59346
    Syja_N; SacI homology domain
  2. NM_001164483.1NP_001157955.1  synaptojanin-1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC134560, AK080946, AW045957, BU703932, BY267025, CF741221, CV558169, CX239305, EL606634
    Consensus CDS
    CCDS49907.1
    UniProtKB/TrEMBL
    D3Z656
    Related
    ENSMUSP00000113308, OTTMUSP00000035111, ENSMUST00000121759, OTTMUST00000069191
    Conserved Domains (5) summary
    cd09098
    Location:573908
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:9511006
    RRM; RNA recognition motif
    cd12719
    Location:9331009
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:99386
    Syja_N; SacI homology domain
    pfam11235
    Location:12701440
    Med25_SD1; Mediator complex subunit 25 synapsin 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    90936092..91012137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246088.1XP_011244390.1  

    Related
    ENSMUSP00000113518, OTTMUSP00000035112, ENSMUST00000118390, OTTMUST00000069192
    Conserved Domains (4) summary
    cd09098
    Location:6771012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10551110
    RRM; RNA recognition motif
    cd12719
    Location:10371113
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
  2. XM_011246076.1XP_011244378.1  

    Conserved Domains (5) summary
    cd09098
    Location:6721007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10501105
    RRM; RNA recognition motif
    cd12719
    Location:10321108
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13691539
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  3. XM_011246075.1XP_011244377.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13771547
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  4. XM_011246077.1XP_011244379.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13641534
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  5. XM_011246078.1XP_011244380.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13611531
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  6. XM_011246079.1XP_011244381.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13481518
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  7. XM_011246080.1XP_011244382.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13481518
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  8. XM_006522837.2XP_006522900.1  

    Conserved Domains (5) summary
    cd09098
    Location:6771012
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10551110
    RRM; RNA recognition motif
    cd12719
    Location:10371113
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13581528
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  9. XM_011246082.1XP_011244384.1  

    Conserved Domains (5) summary
    cd09098
    Location:6721007
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10501105
    RRM; RNA recognition motif
    cd12719
    Location:10321108
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13271497
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  10. XM_011246081.1XP_011244383.1  

    Conserved Domains (5) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
    pfam11235
    Location:13351505
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  11. XM_011246084.1XP_011244386.1  

    Conserved Domains (5) summary
    cd09098
    Location:528863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:906961
    RRM; RNA recognition motif
    cd12719
    Location:888964
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:59346
    Syja_N; SacI homology domain
    pfam11235
    Location:12251395
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  12. XM_011246083.1XP_011244385.1  

    Conserved Domains (5) summary
    cd09098
    Location:536871
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:914969
    RRM; RNA recognition motif
    cd12719
    Location:896972
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:59346
    Syja_N; SacI homology domain
    pfam11235
    Location:12331403
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  13. XM_011246089.1XP_011244391.1  

    Conserved Domains (3) summary
    cd09098
    Location:86421
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:464519
    RRM; RNA recognition motif
    cd12719
    Location:446522
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
  14. XM_006522846.2XP_006522909.1  

    Conserved Domains (3) summary
    cd09098
    Location:14349
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:392447
    RRM; RNA recognition motif
    cd12719
    Location:374450
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
  15. XM_011246085.1XP_011244387.1  

    See identical proteins and their annotated locations for XP_011244387.1

    Conserved Domains (4) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
  16. XM_011246087.1XP_011244389.1  

    Conserved Domains (4) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain
  17. XM_011246086.1XP_011244388.1  

    See identical proteins and their annotated locations for XP_011244388.1

    Conserved Domains (4) summary
    cd09098
    Location:6801015
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    smart00360
    Location:10581113
    RRM; RNA recognition motif
    cd12719
    Location:10401116
    RRM_SYNJ1; RNA recognition motif in synaptojanin-1 and similar proteins
    pfam02383
    Location:203490
    Syja_N; SacI homology domain

RNA

  1. XR_876128.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    92017943..92093156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)