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    MYL9 myosin, light chain 9, regulatory [ Homo sapiens (human) ]

    Gene ID: 10398, updated on 18-May-2013
    Official Symbol
    MYL9provided by HGNC
    Official Full Name
    myosin, light chain 9, regulatoryprovided by HGNC
    Primary source
    HGNC:15754
    Locus tag
    RP5-977B1.9
    See related
    Ensembl:ENSG00000101335; HPRD:17619; MIM:609905; Vega:OTTHUMG00000032387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LC20; MLC2; MRLC1; MYRL2; MLC-2C
    Summary
    Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    20q11.23
    Sequence :
    Chromosome: 20; NC_000020.10 (35169887..35178226)
    See MYL9 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene AAR2 splicing factor homolog (S. cerevisiae) Neighboring gene discs, large (Drosophila) homolog-associated protein 4 Neighboring gene TGIF2-C20orf24 readthrough Neighboring gene TGFB-induced factor homeobox 2 Neighboring gene chromosome 20 open reading frame 24 Neighboring gene Src-like-adaptor 2

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P24844 Q5VT25 CDC42BPA    HPRD  PubMed  
    P24844 P35579 MYH9    HPRD  PubMed  
    BioGRID:115670 BioGRID:117646 FBXO25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115670 BioGRID:125700 LRRK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115670 BioGRID:122884 MYH14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115670 BioGRID:110712 MYH9    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:115670 BioGRID:115871 MYL12A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115670 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115670 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115670 BioGRID:114181 TP63    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115670 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115670 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystemMuscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called actio...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

    Markers

    Homology

    Clone Names

    • MGC3505

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
     
    muscle contraction TAS
    Traceable Author Statement
    more info
     
    regulation of muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    muscle myosin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    myosin regulatory light polypeptide 9
    Names
    myosin regulatory light polypeptide 9
    myosin RLC
    20 kDa myosin light chain
    myosin regulatory light chain 1
    myosin regulatory light chain 9
    myosin regulatory light chain MRLC1
    myosin, light polypeptide 9, regulatory
    myosin regulatory light chain 2, smooth muscle isoform

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006097.4NP_006088.2  myosin regulatory light polypeptide 9 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK130879, AL697699, BC002648
      Consensus CDS
      CCDS13276.1
      UniProtKB/Swiss-Prot
      P24844
      Related
      ENSP00000279022, OTTHUMP00000030857, ENST00000279022, OTTHUMT00000079015
      Conserved Domains (2) summary
      COG5126
      Location:20169
      Blast Score: 309
      FRQ1; Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]
      cd00051
      Location:3377
      Blast Score: 103
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_181526.2NP_852667.1  myosin regulatory light polypeptide 9 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AL697699, BC002648
      Consensus CDS
      CCDS13277.1
      UniProtKB/Swiss-Prot
      P24844
      Related
      ENSP00000217313, OTTHUMP00000030858, ENST00000346786, OTTHUMT00000079016
      Conserved Domains (2) summary
      pfam13833
      Location:62111
      Blast Score: 79
      EF_hand_6; EF-hand domain pair
      cd00051
      Location:33110
      Blast Score: 98
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p10 Primary Assembly

      Range
      35169887..35178226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      31906489..31914828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018931.1 Alternate CHM1_1.0

      Range
      35134759..35143098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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