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CFLAR CASP8 and FADD like apoptosis regulator [ Aptenodytes forsteri (emperor penguin) ]

Gene ID: 103903458, updated on 11-Mar-2024

Summary

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Gene symbol
CFLAR
Gene description
CASP8 and FADD like apoptosis regulator
Gene type
protein coding
RefSeq status
MODEL
Organism
Aptenodytes forsteri
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Aptenodytes
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
101 current ASM69914v1 (GCF_000699145.1) Unplaced Scaffold NW_008795918.1 (1581777..1604894, complement)

NW_008795918.1Genomic Context describing neighboring genes Neighboring gene caspase-8 Neighboring gene caspase-10 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008795918.1 Unplaced Scaffold Reference ASM69914v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CASP8 and FADD-like apoptosis regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Aptenodytes forsteri Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM69914v1

Genomic

  1. NW_008795918.1 Reference ASM69914v1

    Range
    1581777..1604894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009284660.2 → XP_009282935.1  CASP8 and FADD-like apoptosis regulator isoform X2

    Conserved Domains (3) summary
    cd08337
    Location:6 → 85
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96 → 176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:251 → 487
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_009284659.2 → XP_009282934.1  CASP8 and FADD-like apoptosis regulator isoform X1

    Conserved Domains (3) summary
    cd08337
    Location:6 → 85
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96 → 176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:252 → 488
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RNA

  1. XR_657856.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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