IRF9 interferon regulatory factor 9 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IRF9provided by HGNC
Official Full Name: interferon regulatory factor 9provided by HGNC
Primary source: HGNC:6131
See related: Ensembl:ENSG00000213928; HPRD:00960; MIM:147574; Vega:OTTHUMG00000028799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p48; IRF-9; ISGF3; ISGF3G

Genomic context

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Location :: 14q11.2

Sequence :: Chromosome: 14; NC_000014.8 (24630422..24635774)

See IRF9 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

HDAC1 and HDAC2 differentially modulate STAT activity in response to IFNalpha2: while they are required for the induction of ISGF3-responsive genes, they impair the transcription of STAT3-dependent genes.
Title: Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2.
Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of human herpesvirus 8 vIRF-2 activity.
Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.
STAT2 may interact with IRF-9 in a STAT1-independent manner. The complex STAT2/IRF-9 is the key factor mediating the expression of RIG-G gene regulated by IFN-alpha.
Title: [A novel molecular mechanism of interferon alpha-regulated expression of retinoic acid-induced gene G].
Signals ensued by IFN-alpha and IL-4 induce cytoplasmic sequestration of IL-4-activated STAT6 and IFN-alpha-activated STAT2:p48 in B cells through the formation of pY-STAT6:pY-STAT2:p48 complex.
Title: Counter-regulation mechanism of IL-4 and IFN-α signal transduction through cytosolic retention of the pY-STAT6:pY-STAT2:p48 complex.
analysis of IFN-stimulated response elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN response factor 7 (IRF7)
Title: Transcription factor redundancy ensures induction of the antiviral state.
Results suggest that the amount of cellular IRF9 is a crucial determinant for amplification of early dynamics of IFNalpha-mediated signal transduction.
Title: Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling.
a key factor for eliciting the antiproliferative activity of IFN-alpha in tumors
Title: IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha.
NOD1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections
Title: NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
Suggest that the JAK-STAT pathway may play a major role in mediating the effects of IFN-alpha against hepatitis b virus, and that ISGF3 might be a key factor.
Title: Role of ISGF3 in modulating the anti-hepatitis B virus activity of interferon-alpha in vitro.

Submit: New GeneRIF Correction See all (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006075.3	NP_005410.1	STAT2	BIND	PubMed	Stat2 interacts with p48. This interaction is modelled on a demonstrated interaction between stat2 from an unspecified species and human p48.
Q00978	Interferon, alpha 1	IFNA1	HPRD	PubMed
Q00978	P42224	STAT1	HPRD	PubMed
Q00978	P52630	STAT2	HPRD	PubMed
BioGRID:115652	BioGRID:115865	ARID3B	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115652	BioGRID:125560	DACH2	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:122010	DMRTC2	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:108125	DNMT3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115652	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:115652	BioGRID:109465	HOXC9	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:109677	IFNAR2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115652	BioGRID:109867	IRF1	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:117576	IRF2BP1	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:110638	MYO1F	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:110857	NFKB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115652	BioGRID:115320	NR2E3	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:111447	POU2F1	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:111902	RELA	BioGRID	PubMed	Reconstituted Complex
BioGRID:115652	BioGRID:112192	S100A13	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:112649	STAT1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115652	BioGRID:112650	STAT2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115652	BioGRID:109436	TLX2	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:119030	TLX3	BioGRID	PubMed	Two-hybrid
BioGRID:115652	BioGRID:113003	TOP1	BioGRID	PubMed	Protein-peptide
BioGRID:115652	BioGRID:118111	VENTX	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
IFN-gamma pathway, organism-specific biosystem
IFN-gamma pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
Type III interferon signaling, organism-specific biosystem (from WikiPathways)
Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

General gene information

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Markers

SHGC-132043 (e-PCR)
- UniSTS:173887

D14S1328 (e-PCR)
- UniSTS:36672

RH76410 (e-PCR)
- UniSTS:87460

G64280 (e-PCR)
- UniSTS:158660

RH1632 (e-PCR)
- UniSTS:33241

Homology

Homologs of the IRF9 gene: The IRF9 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
regulatory region DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
defense response to virus	IEA Inferred from Electronic Annotation more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
type I interferon biosynthetic process	IEA Inferred from Electronic Annotation more info
type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 9

Names: interferon regulatory factor 9; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcriptional regulator ISGF3 subunit gamma; IFN-alpha-responsive transcription factor subunit; interferon-stimulated transcription factor 3, gamma 48kDa; interferon-stimulated transcription factor 3, gamma (48kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006084.4 → NP_006075.3 interferon regulatory factor 9

Status: VALIDATED

Source sequence(s)

AL136295, BI497082, BI919023

Consensus CDS

CCDS9615.1

UniProtKB/Swiss-Prot

Q00978

Related

ENSP00000380073, OTTHUMP00000164693, ENST00000396864, OTTHUMT00000071927

Conserved Domains (2) summary

cd00103
Location:10 – 116
Blast Score: 372

IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

pfam10401
Location:217 – 382
Blast Score: 459

IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p10 Primary Assembly

Range

24630422..24635774

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

4745386..4750738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018925.1 Alternate CHM1_1.0

Range

5627712..5633064

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01061334.1 (7238..12590)	None
genomic	AL136295.3 (43470..48736)	None
genomic	AMYH01005610.1 (48142..53494)	None
genomic	CH471078.2	EAW66092.1
		EAW66093.1
		EAW66094.1
genomic	G13571.1	None
mRNA	AK295467.1	BAG58398.1
mRNA	AK308347.1	None
mRNA	BC035716.2	AAH35716.1
mRNA	BI497082.1	None
mRNA	BI919023.1	None
mRNA	M87503.1	AAA58687.1
mRNA	U92994.1	None
other-genetic	EU446692.1	ABZ92221.1