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Trio trio Rho guanine nucleotide exchange factor [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

Gene ID: 103724647, updated on 11-Mar-2024

Summary

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Gene symbol
Trio
Gene description
trio Rho guanine nucleotide exchange factor
See related
Ensembl:ENSNGAG00000022178
Gene type
protein coding
RefSeq status
MODEL
Organism
Nannospalax galili
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
Orthologs
human mouse all
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Genomic context

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See Trio in Genome Data Viewer
Location:
chromosome: Un
Exon count:
60
Annotation release Status Assembly Chr Location
102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008358517.1 (6893817..7242533, complement)

NW_008358517.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene guanine nucleotide-binding protein G(i) subunit alpha-2-like Neighboring gene uncharacterized LOC115068196 Neighboring gene dynein axonemal heavy chain 5 Neighboring gene sentrin-specific protease 2-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008358517 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. Malik A, et al. PLoS One, 2011. PMID 21857902, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
triple functional domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference S.galili_v1.0 Primary Assembly

Genomic

  1. NW_008358517.1 Reference S.galili_v1.0 Primary Assembly

    Range
    6893817..7242533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029557993.1 → XP_029413853.1  triple functional domain protein isoform X3

    UniProtKB/TrEMBL
    A0A8C6RZK8
    Related
    ENSNGAP00000023735.1, ENSNGAT00000029437.1
    Conserved Domains (11) summary
    smart00150
    Location:1104 → 1204
    SPEC; Spectrin repeats
    cd11852
    Location:1620 → 1679
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2526 → 2584
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:30 → 165
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1931 → 2104
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:528 → 744
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1433 → 1555
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2758 → 3020
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:2655 → 2746
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1677 → 1924
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  2. XM_029557991.1 → XP_029413851.1  triple functional domain protein isoform X1

    Conserved Domains (7) summary
    smart00150
    Location:1104 → 1204
    SPEC; Spectrin repeats
    cd11852
    Location:1620 → 1679
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:30 → 165
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1256 → 1426
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:528 → 744
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1433 → 1555
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam16609
    Location:1677 → 1696
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  3. XM_029557992.1 → XP_029413852.1  triple functional domain protein isoform X2

    Conserved Domains (7) summary
    smart00150
    Location:1104 → 1204
    SPEC; Spectrin repeats
    cd11852
    Location:1620 → 1679
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:30 → 165
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1256 → 1426
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:528 → 744
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1433 → 1555
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam16609
    Location:1677 → 1695
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
Nucleotide Protein
Heading Accession and Version

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