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ITSN1 intersectin 1 [ Ursus maritimus (polar bear) ]

Gene ID: 103673121, updated on 11-Mar-2024

Summary

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Gene symbol
ITSN1
Gene description
intersectin 1
See related
Ensembl:ENSUMAG00000020085
Gene type
protein coding
RefSeq status
MODEL
Organism
Ursus maritimus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
43
Annotation release Status Assembly Chr Location
101 current ASM1731132v1 (GCF_017311325.1) Unplaced Scaffold NW_024426552.1 (11127403..11332738, complement)
100 previous assembly UrsMar_1.0 (GCF_000687225.1) Unplaced Scaffold NW_007907200.1 (22989599..23188654)

NW_024426552.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit ATP5MPL, mitochondrial-like Neighboring gene ATP synthase peripheral stalk subunit OSCP Neighboring gene uncharacterized LOC103673120 Neighboring gene crystallin zeta like 1 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene SON DNA and RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ursus maritimus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1731132v1 Primary Assembly

Genomic

  1. NW_024426552.1 Reference ASM1731132v1 Primary Assembly

    Range
    11127403..11332738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040621007.1 → XP_040476941.1  intersectin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M1F0Y5
    Conserved Domains (12) summary
    cd08375
    Location:1577 → 1711
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:912 → 963
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:1001 → 1052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1069 → 1133
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1233 → 1416
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:798 → 912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1435 → 1577
    PH_13; Pleckstrin homology domain
    NF033761
    Location:99 → 192
    gliding_GltJ; adventurous gliding motility protein GltJ
    cl17036
    Location:1153 → 1206
    SH3; Src Homology 3 domain superfamily

  2. XM_040621006.1 → XP_040476940.1  intersectin-1 isoform X4

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F4A0
    Conserved Domains (7) summary
    PRK14959
    Location:42 → 192
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    smart01104
    Location:772 → 900
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16228
    Location:604 → 726
    DUF4887; Domain of unknown function (DUF4887)
    cl17036
    Location:1001 → 1062
    SH3; Src Homology 3 domain superfamily

  3. XM_040621004.1 → XP_040476938.1  intersectin-1 isoform X2

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F0J7
    Conserved Domains (8) summary
    PRK14959
    Location:11 → 161
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:183 → 278
    EH; Eps15 homology domain
    cd11987
    Location:713 → 767
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:970 → 1021
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    smart01104
    Location:741 → 869
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG1196
    Location:332 → 626
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16228
    Location:573 → 695
    DUF4887; Domain of unknown function (DUF4887)
    cl17036
    Location:1038 → 1102
    SH3; Src Homology 3 domain superfamily

  4. XM_040621001.1 → XP_040476935.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F804
    Conserved Domains (7) summary
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:1001 → 1052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    PLN02983
    Location:93 → 202
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:798 → 912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1069 → 1133
    SH3; Src Homology 3 domain superfamily

  5. XM_040621003.1 → XP_040476937.1  intersectin-1 isoform X2

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F0J7
    Conserved Domains (8) summary
    PRK14959
    Location:11 → 161
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    smart00027
    Location:183 → 278
    EH; Eps15 homology domain
    cd11987
    Location:713 → 767
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:970 → 1021
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    smart01104
    Location:741 → 869
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG1196
    Location:332 → 626
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16228
    Location:573 → 695
    DUF4887; Domain of unknown function (DUF4887)
    cl17036
    Location:1038 → 1102
    SH3; Src Homology 3 domain superfamily

  6. XM_040620999.1 → XP_040476933.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F804
    Conserved Domains (7) summary
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:1001 → 1052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    PLN02983
    Location:93 → 202
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:798 → 912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1069 → 1133
    SH3; Src Homology 3 domain superfamily

  7. XM_040621000.1 → XP_040476934.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F804
    Conserved Domains (7) summary
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:1001 → 1052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    PLN02983
    Location:93 → 202
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:798 → 912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1069 → 1133
    SH3; Src Homology 3 domain superfamily

  8. XM_040621002.1 → XP_040476936.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F804
    Conserved Domains (7) summary
    smart00027
    Location:214 → 309
    EH; Eps15 homology domain
    cd11987
    Location:744 → 798
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:1001 → 1052
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    PLN02983
    Location:93 → 202
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    COG1196
    Location:363 → 657
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:798 → 912
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1069 → 1133
    SH3; Src Homology 3 domain superfamily

  9. XM_040621005.1 → XP_040476939.1  intersectin-1 isoform X3

    UniProtKB/TrEMBL
    A0A452V2K2, A0A8M1F809
    Conserved Domains (9) summary
    smart00027
    Location:148 → 243
    EH; Eps15 homology domain
    cd11987
    Location:678 → 732
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:935 → 986
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    smart01104
    Location:706 → 834
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    PLN02983
    Location:27 → 136
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    COG1196
    Location:297 → 591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl27812
    Location:1 → 42
    EF-hand_4; Cytoskeletal-regulatory complex EF hand
    pfam16228
    Location:538 → 660
    DUF4887; Domain of unknown function (DUF4887)
    cl17036
    Location:1003 → 1067
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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