KLF2 Kruppel-like factor 2 (lung) [Homo sapiens] - Gene

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Summary

Official Symbol: KLF2provided by HGNC
Official Full Name: Kruppel-like factor 2 (lung)provided by HGNC
Primary source: HGNC:6347
See related: Ensembl:ENSG00000127528; HPRD:03602; MIM:602016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LKLF
Summary: Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]

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Genomic context

Location :: 19p13.11

Sequence :: Chromosome: 19; NC_000019.9 (16435651..16438345)

See KLF2 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-92a coregulates KLF4 and KLF2 expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
Title: Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.
Data show that extracellular vesicles secreted by KLF2-transduced or shear-stress-stimulated umbilical vein endothelial cells (HUVECs) are enriched in miR-143/145 and control target gene expression in co-cultured smooth muscle cell (SMC).
Title: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Title: Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells
Title: Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells.
KLF1 and KLF2 positively regulate the embryonic and fetal beta-globin genes through direct promoter binding.
Title: Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding.
Atheroprotective flow patterns decrease the level of miR-92a, which in turn increases KLF2 expression to maintain endothelial homeostasis.
Title: Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.
Low KLF2 is associated with acute myeloid leukemia.
Title: Deregulated expression of Kruppel-like factors in acute myeloid leukemia.
This study provided the first evidence that Smurf1 functions as an E3 ligase to promote the ubiquitination and proteasomal degradation of KLF2.
Title: Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.
Kruppel-like factor 2 is involved in the enhanced secretion of MCP-1 by M2 macrophages loaded with oxidized LDL.
Title: Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2.
KLF2 plays a critical role in dictating normal subset differentiation and functional reactivity of mature B cells
Title: Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression.

Submit: New GeneRIF Correction See all (53)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_057354.1	NC_000011.8	WEE1	BIND	PubMed	KLF2 interacts with the SP1/CPBP motif of the WEE1 promoter.
Q9Y5W3	Q09472	EP300	HPRD	PubMed
Q9Y5W3	Q9H0M0	WWP1	HPRD	PubMed
BioGRID:115645	BioGRID:126640	GATA5	BioGRID	PubMed	Two-hybrid
BioGRID:115645	BioGRID:108897	GATA6	BioGRID	PubMed	Two-hybrid
BioGRID:115645	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115645	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115645	BioGRID:116243	WWP1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid

Function	Evidence Code	Pubs
metal ion binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell morphogenesis	IEA Inferred from Electronic Annotation more info
cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
erythrocyte homeostasis	IEA Inferred from Electronic Annotation more info
erythrocyte maturation	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
multicellular organism growth	IEA Inferred from Electronic Annotation more info
negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
positive regulation of protein metabolic process	IGI Inferred from Genetic Interaction more info
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info
response to laminar fluid shear stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: Krueppel-like factor 2

Names: Krueppel-like factor 2; Kruppel-like factor LKLF; lung krueppel-like factor; lung Kruppel-like zinc finger transcription factor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016270.2 → NP_057354.1 Krueppel-like factor 2

Status: VALIDATED

Source sequence(s)

AF134053, AF205849, BC035342, BQ581981, CA950627

Consensus CDS

CCDS12343.1

UniProtKB/TrEMBL

Q8IUN4

UniProtKB/Swiss-Prot

Q9Y5W3

Related

ENSP00000248071, ENST00000248071

Conserved Domains (2) summary

COG5048
Location:267 – 352
Blast Score: 114

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:318 – 343
Blast Score: 92

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

16435651..16438345

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

16006724..16007405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC020917.4 (11685..14379)	None
genomic	AF123344.1	AAD25076.1
genomic	CH471106.1	EAW84541.1
genomic	HI179182.1	CBX53899.1
genomic	HI574216.1	CBX47597.1
mRNA	AF134053.1	AAD55891.1
mRNA	AF205849.1	AAF13295.1
mRNA	AK225820.1	None
mRNA	BC035342.1	AAH35342.1
mRNA	BC071983.1	AAH71983.1
mRNA	BQ581981.1	None
mRNA	CA950627.1	None