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NEDD4 NEDD4 E3 ubiquitin protein ligase [ Corvus brachyrhynchos (American crow) ]

Gene ID: 103618752, updated on 11-Mar-2024

Summary

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Gene symbol
NEDD4
Gene description
NEDD4 E3 ubiquitin protein ligase
Locus tag
N302_04915
Gene type
protein coding
RefSeq status
MODEL
Organism
Corvus brachyrhynchos
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae; Corvus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
30
Annotation release Status Assembly Chr Location
101 current ASM69197v1 (GCF_000691975.1) Unplaced Scaffold NW_008236184.1 (4009521..4060469)

NW_008236184.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108447568 Neighboring gene uncharacterized LOC108447570 Neighboring gene regulatory factor X7 Neighboring gene protogenin Neighboring gene IQ motif containing GTPase activating protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008236184.1 Unplaced Scaffold Reference ASM69197v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEDD4
Names
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Corvus brachyrhynchos Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM69197v1

Genomic

  1. NW_008236184.1 Reference ASM69197v1

    Range
    4009521..4060469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008637207.2 → XP_008635429.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    A0A091E5J5
    Conserved Domains (5) summary
    smart00456
    Location:357 → 389
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:450 → 779
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:426 → 780
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:307 → 336
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  2. XM_017738056.1 → XP_017593545.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    A0A091E5J5
    Conserved Domains (5) summary
    smart00456
    Location:357 → 389
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:450 → 779
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:426 → 780
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:307 → 336
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  3. XM_017738063.1 → XP_017593552.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    A0A091E5J5
    Conserved Domains (5) summary
    smart00456
    Location:357 → 389
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:450 → 779
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:426 → 780
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:307 → 336
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  4. XM_017738065.1 → XP_017593554.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    A0A091E5J5
    Conserved Domains (5) summary
    smart00456
    Location:357 → 389
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:450 → 779
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:426 → 780
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:307 → 336
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  5. XM_017738069.1 → XP_017593558.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    A0A091E5J5
    Conserved Domains (5) summary
    smart00456
    Location:357 → 389
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:450 → 779
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:426 → 780
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:307 → 336
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  6. XM_008637192.2 → XP_008635414.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

    Conserved Domains (7) summary
    smart00456
    Location:883 → 915
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:976 → 1305
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:952 → 1306
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:834 → 864
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:603 → 630
    WW; WW domain
    pfam16210
    Location:95 → 186
    Keratin_2_tail; Keratin type II cytoskeletal 1 tail
    cl14603
    Location:505 → 558
    C2; C2 domain

  7. XM_017738050.1 → XP_017593539.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

RNA

  1. XR_001863230.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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