Xpo1 exportin 1, CRM1 homolog (yeast) [Mus musculus] - Gene

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Summary

Official Symbol: Xpo1provided by MGI
Official Full Name: exportin 1, CRM1 homolog (yeast)provided by MGI
Primary source: MGI:2144013
Locus tag: RP23-305E10.1
See related: Ensembl:ENSMUSG00000020290; Vega:OTTMUSG00000005274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crm1; Exp1; AA420417

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Genomic context

Location :: 11 A3.2; 11

Sequence :: Chromosome: 11; NC_000077.6 (23256041..23297597)

See Xpo1 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
Title: Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor
Title: CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor.
UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling
Title: The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.
p53 subcellular localization resulting from CRM1 alterations may play an important role in lung tumorigenesis
Title: CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model.
These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1-mediated nuclear export in conjunction with RanBP3.
Title: The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export.
Crm1 inhibition promotes accumulation of p65 NF-kB in nuclei of poly(ADP-ribose) polymerase-1-deficient cells and reverses expression of NF-kappaB-dependent genes upon Toll-like receptor (TLR)4 stimulation.
Title: Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.
Inhibiting Crm1 in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
Title: Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
study presents the crystal structure of the SPN1.CRM1.RanGTP export complex at 2.5 angstrom resolution (where SPN1 is snurportin1 and RanGTP is guanosine 5' triphosphate-bound Ran
Title: Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
Phosphorylation of ChREBP was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with importin alpha.
Title: Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.
TRalpha may follow a cooperative export pathway in which both calreticulin and CRM1 play a role in facilitating efficient translocation of TRalpha from the nucleus to cytoplasm
Title: Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway.

Submit: New GeneRIF Correction See all (18)

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_598775.2	NP_031704.1	Cebpa	BIND	PubMed	Phosphorylated C/EBP-alpha interacts with CRM1.
NP_598775.2	NP_034013.1	Cebpb	BIND	PubMed	Phosphorylated C/EBP-beta interacts with CRM1.
BioGRID:222117	BioGRID:198294	Bach1	BioGRID	PubMed	Reconstituted Complex
BioGRID:222117	BioGRID:198877	Crem	BioGRID	PubMed	Affinity Capture-MS
BioGRID:222117	BioGRID:108468	FABP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:222117	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:222117	BioGRID:112112	RPS6KB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:222117	BioGRID:113335	XDH	BioGRID	PubMed	Affinity Capture-MS
BioGRID:222117	BioGRID:113348	XPO1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	ISO Inferred from Sequence Orthology more info
protein transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
intracellular protein transport	IEA Inferred from Electronic Annotation more info
mRNA transport	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
protein export from nucleus	ISO Inferred from Sequence Orthology more info
protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
protein transport	IEA Inferred from Electronic Annotation more info
regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
annulate lamellae	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IMP Inferred from Mutant Phenotype more info	PubMed
kinetochore	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

Preferred Names: exportin-1

Names: exportin-1; chromosome region maintenance 1 protein homolog

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035226.1 → NP_001030303.1 exportin-1

Status: VALIDATED

Source sequence(s)

AK037196, BC062912

Consensus CDS

CCDS24475.1

UniProtKB/TrEMBL

A2AKT7

UniProtKB/Swiss-Prot

Q6P5F9

UniProtKB/TrEMBL

Q8BYY5

Related

ENSMUSP00000105178, ENSMUST00000109551

Conserved Domains (4) summary

COG5101
Location:15 – 1044
Blast Score: 2901

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:123 – 268
Blast Score: 426

Xpo1; Exportin 1-like protein

cl04271
Location:46 – 112
Blast Score: 167

IBN_N; Importin-beta N-terminal domain

cl07396
Location:709 – 1027
Blast Score: 1268

CRM1_C; CRM1 C terminal
NM_134014.3 → NP_598775.2 exportin-1

Status: VALIDATED

Source sequence(s)

AK037196, BC062912, CD347786

Consensus CDS

CCDS24475.1

UniProtKB/TrEMBL

A2AKT7

UniProtKB/Swiss-Prot

Q6P5F9

UniProtKB/TrEMBL

Q8BYY5

Related

ENSMUSP00000020538, ENSMUST00000020538

Conserved Domains (4) summary

COG5101
Location:15 – 1044
Blast Score: 2901

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam08389
Location:123 – 268
Blast Score: 426

Xpo1; Exportin 1-like protein

cl04271
Location:46 – 112
Blast Score: 167

IBN_N; Importin-beta N-terminal domain

cl07396
Location:709 – 1027
Blast Score: 1268

CRM1_C; CRM1 C terminal

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38 C57BL/6J

Range

23256041..23297597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

25383230..25424813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL772359.8	CAM20291.1
		CAM20292.1
		CAM20293.1
genomic	CH466595.1	EDL07881.1	mixed
		EDL07882.1	mixed
mRNA	AA796668.1	None	C57BL/6J
mRNA	AK037196.1	BAC29747.1	C57BL/6J
mRNA	AK052007.1	None	C57BL/6J
mRNA	AK136538.1	None	C57BL/6J
mRNA	AK142055.1	None	C57BL/6J
mRNA	BB610152.1	None	C57BL/6J
mRNA	BC012276.1	AAH12276.1	FVB/N
mRNA	BC025628.1	AAH25628.1	FVB/N
mRNA	BC029714.1	None	FVB/N
mRNA	BC034710.1	None	CZECHII
mRNA	BC062912.1	AAH62912.1	C57BL/6
mRNA	BQ180141.1	None	C57BL/6
mRNA	BQ831940.1	None	C57BL/6J
mRNA	BU052960.1	None	C57BL/6
mRNA	CA325110.1	None	C57BL/6
mRNA	CB518654.1	None	C57BL/6
mRNA	CD347786.1	None	C57BL/6
mRNA	CF538023.1	None	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q6P5F9.1	GenPept	UniProtKB/Swiss-Prot:Q6P5F9
Q8BYY5	GenPept	UniProtKB/TrEMBL:Q8BYY5
Q921J0	GenPept	UniProtKB/TrEMBL:Q921J0