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PDE8A phosphodiesterase 8A [ Equus przewalskii (Przewalski's horse) ]

Gene ID: 103546227, updated on 11-Mar-2024

Summary

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Gene symbol
PDE8A
Gene description
phosphodiesterase 8A
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus przewalskii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
100 current Burgud (GCF_000696695.1) Unplaced Scaffold NW_007673157.1 (885888..1017952)

NW_007673157.1Genomic Context describing neighboring genes Neighboring gene alpha kinase 3 Neighboring gene solute carrier family 28 member 1 Neighboring gene uncharacterized LOC103546228 Neighboring gene uncharacterized LOC103546229

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_007673157 unplaced scaffold reference Burgud Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus przewalskii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Burgud Primary Assembly

Genomic

  1. NW_007673157.1 Reference Burgud Primary Assembly

    Range
    885888..1017952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008512673.1 → XP_008510895.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    Conserved Domains (5) summary
    COG0745
    Location:52 → 129
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    cd00130
    Location:200 → 294
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:525 → 777
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:196 → 294
    PAS_9; PAS domain
    cl19078
    Location:53 → 139
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

  2. XM_008512674.1 → XP_008510896.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    See identical proteins and their annotated locations for XP_008510896.1

    Conserved Domains (3) summary
    cd00130
    Location:77 → 171
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:402 → 654
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:73 → 171
    PAS_9; PAS domain
Nucleotide Protein
Heading Accession and Version

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