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sos2 son of sevenless homolog 2 (Drosophila) [ Cynoglossus semilaevis (tongue sole) ]

Gene ID: 103380955, updated on 11-Mar-2024

Summary

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Gene symbol
sos2
Gene description
son of sevenless homolog 2 (Drosophila)
See related
Ensembl:ENSCSEG00000007873
Gene type
protein coding
RefSeq status
MODEL
Organism
Cynoglossus semilaevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae; Cynoglossinae; Cynoglossus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
102 current Cse_v1.0 (GCF_000523025.1) 1 NC_024307.1 (15089853..15118188)

Chromosome 1 - NC_024307.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase-like 1 (CDC2-related kinase) Neighboring gene distal membrane arm assembly component 2 like Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized LOC103381346 Neighboring gene cyclin-dependent kinase inhibitor 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_024307.1 Chromosome 1 Reference Cse_v1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2
Names
SOS Ras/Rho guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cynoglossus semilaevis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cse_v1.0 Primary Assembly

Genomic

  1. NC_024307.1 Reference Cse_v1.0 Primary Assembly

    Range
    15089853..15118188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008313111.3 → XP_008311333.1  son of sevenless homolog 2

    UniProtKB/TrEMBL
    A0A3P8VAE3, A0A3P8VD07
    Related
    ENSCSEP00000012323.1, ENSCSET00000012469.1
    Conserved Domains (7) summary
    smart00229
    Location:595 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:777 → 1014
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam00125
    Location:62 → 168
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:443 → 539
    PH; PH domain
    cl17171
    Location:437 → 543
    PH-like; Pleckstrin homology-like domain
    cl23907
    Location:96 → 146
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
Nucleotide Protein
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