CDKN3 cyclin-dependent kinase inhibitor 3 [Homo sapiens] - Gene

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Summary

Official Symbol: CDKN3provided by HGNC
Official Full Name: cyclin-dependent kinase inhibitor 3provided by HGNC
Primary source: HGNC:1791
See related: Ensembl:ENSG00000100526; HPRD:00450; MIM:123832; Vega:OTTHUMG00000140302
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KAP; CDI1; CIP2; KAP1; FLJ25787; MGC70625
Summary: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

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Genomic context

Location :: 14q22

Sequence :: Chromosome: 14; NC_000014.8 (54863673..54886936)

See CDKN3 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that CDKN3 acts as an oncogene in human hepatocellular carcinoma and antagonism of CDKN3 may be of interest for the treatment of HCC.
Title: Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation.
analysis of CDKN3 cell cycle networks and the molecular mechanism of non-malignancy associated hepatitis/cirrhosis and HCC transformation
Title: Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation.
Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
IKKalpha, IKKbeta, RANK, Maspin, c-FLIP, Cip2 and cyclinD1 were found to show significant differences between hepatocellular tumor tissue and its corresponding adjacent tissue.
Title: High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
In choline-deficient neuroblastoma cells, the promoter of the cyclin-dependent kinase inhibitor 3 gene (CDKN3) was hypomethylated. This was associated with increased expression of CDKN3 gene product kinase-associated phosphatase (KAP)
Title: Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene.
Identification of a KAP domain that interacts with cyclin-dependent kinase 2.
Title: Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant.
HTm4 binding to KAP.Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2
Title: Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.
the reduction of KAP1 levels promotes p53-dependent p21 induction and inhibits cell proliferation in actinomycin D-treated cells.
Title: KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction.
Pax3 represses transcription through a novel mechanism involving competition between corepressor KAP1 and the heterochromatin-binding protein HP1gamma
Title: Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q16667	P30304	CDC25A	HPRD	PubMed
Q16667	P06493	CDK1	HPRD	PubMed
Q16667	P24941	CDK2	HPRD	PubMed
Q16667	Q00526	CDK3	HPRD	PubMed
Q16667	Q16667	CDKN3	HPRD	PubMed
Q16667	P49715	CEBPA	HPRD	PubMed
Q16667	Q96HJ5	MS4A3	HPRD	PubMed
BioGRID:107467	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107467	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107467	BioGRID:107370	MS4A3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107467	BioGRID:113841	NCOA3	BioGRID	PubMed	Two-hybrid
BioGRID:107467	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine/serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of cyclin-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: cyclin-dependent kinase inhibitor 3

Names: cyclin-dependent kinase inhibitor 3; kinase associated phosphatase; kinase-associated phosphatase; Cdk-associated protein phosphatase; cyclin-dependent kinase interactor 1; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; cyclin-dependent kinase interacting protein 2; cyclin-dependent kinase-interacting protein 2

NP_001124323.1

EC 3.1.3.16

EC 3.1.3.48

NP_005183.2

EC 3.1.3.16

EC 3.1.3.48

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023235.1 RefSeqGene

Range

5001..28264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001130851.1 → NP_001124323.1 cyclin-dependent kinase inhibitor 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AK098653, BC064965

Consensus CDS

CCDS45109.1

UniProtKB/Swiss-Prot

Q16667

Related

ENSP00000415333, OTTHUMP00000244842, ENST00000442975, OTTHUMT00000411155

Conserved Domains (1) summary

cl00053
Location:61 – 151
Blast Score: 107

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_005192.3 → NP_005183.2 cyclin-dependent kinase inhibitor 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK098653, BC064965

Consensus CDS

CCDS9716.1

UniProtKB/Swiss-Prot

Q16667

Related

ENSP00000335357, OTTHUMP00000178991, ENST00000335183, OTTHUMT00000276893

Conserved Domains (1) summary

cl00053
Location:101 – 191
Blast Score: 108

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

54863673..54886936

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

35026265..35049580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049778.3 (181926..205000)	None
genomic	AL359792.3 (180220..180351)	None
genomic	AY194117.1	AAN86348.1
genomic	CH471061.1	EAW80632.1
		EAW80633.1
		EAW80634.1
mRNA	AF213033.1	AAK06365.1
mRNA	AF213034.1	AAK06366.1
mRNA	AF213035.1	AAK06367.1
mRNA	AF213036.1	AAK06368.1
mRNA	AF213037.1	AAK06369.1
mRNA	AF213038.1	AAK06370.1
mRNA	AF213039.1	AAK06371.1
mRNA	AF213040.1	AAK06372.1
mRNA	AF213041.1	AAK06373.1
mRNA	AF213042.1	AAK06374.1
mRNA	AF213043.1	None
mRNA	AF213044.1	AAK06375.1
mRNA	AF213045.1	AAK06376.1
mRNA	AF213046.1	AAK06377.1
mRNA	AF213047.1	AAK06378.1
mRNA	AF213048.1	AAK06379.1
mRNA	AF213049.1	AAK06380.1
mRNA	AF213050.1	AAK06381.1
mRNA	AF213051.1	AAK06382.1
mRNA	AF213052.1	AAK06383.1
mRNA	AF213053.1	AAK06384.1
mRNA	AK098653.1	None
mRNA	AK293265.1	BAH11478.1
mRNA	AY257474.1	AAP13062.1
mRNA	AY257475.1	AAP13063.1
mRNA	AY257476.1	AAP13064.1
mRNA	AY257477.1	AAP13065.1
mRNA	AY257478.1	AAP13066.1
mRNA	BC064965.1	AAH64965.1
mRNA	BC103633.1	AAI03634.1
mRNA	BT019451.1	AAV38258.1
mRNA	CR407666.1	CAG28594.1
mRNA	EF560750.1	ABQ59060.1
mRNA	L25876.1	AAA60222.1
mRNA	L27711.1	AAA66496.1
mRNA	U02681.1	AAC04932.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q16667.1	GenPept	UniProtKB/Swiss-Prot:Q16667
Q86SK7	GenPept	UniProtKB/TrEMBL:Q86SK7
Q86SK8	GenPept	UniProtKB/TrEMBL:Q86SK8
Q9BPV5	GenPept	UniProtKB/TrEMBL:Q9BPV5
Q9BY34	GenPept	UniProtKB/TrEMBL:Q9BY34
Q9C043	GenPept	UniProtKB/TrEMBL:Q9C043
Q9C044	GenPept	UniProtKB/TrEMBL:Q9C044
Q9C045	GenPept	UniProtKB/TrEMBL:Q9C045
Q9C048	GenPept	UniProtKB/TrEMBL:Q9C048
Q9C050	GenPept	UniProtKB/TrEMBL:Q9C050