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RRAGB Ras related GTP binding B [ Homo sapiens (human) ]

Gene ID: 10325, updated on 13-May-2016
Official Symbol
RRAGBprovided by HGNC
Official Full Name
Ras related GTP binding Bprovided by HGNC
Primary source
HGNC:HGNC:19901
See related
Ensembl:ENSG00000083750 HPRD:06710; MIM:300725; Vega:OTTHUMG00000021662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGB; bA465E19.1
Summary
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xp11.21
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (55717677..55759333)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55744110..55785766)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene forkhead box R2 Neighboring gene XAGE-4 protein Neighboring gene Kruppel-like factor 8 Neighboring gene glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) pseudogene Neighboring gene ribosomal protein L23a pseudogene 83 Neighboring gene Kruppel-like factor 8

NHGRI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of Ras-related GTP binding B (RRAGB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
    Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP rati...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PKB-mediated events, organism-specific biosystem (from REACTOME)
    PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • TOR signaling, organism-specific biosystem (from WikiPathways)
    TOR signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
  • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystem
    mTOR signaling pathway
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...
  • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
    mTORC1-mediated signalling, organism-specific biosystemmTORC1 integrates four major signals growth factors, energy status, oxygen and amino acids to regulate many processes that are involved in the promotion of cell growth. Growth factors stimulate mTO...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanyl ribonucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of TOR signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
EGO complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ras-related GTP-binding protein B
Names
GTP-binding protein ragB
RRAGB
Ras-related GTP binding B
rag B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006064.4NP_006055.3  ras-related GTP-binding protein B short isoform

    See identical proteins and their annotated locations for NP_006055.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (RAGBs) lacks an alternate in-frame exon in the coding region, compared to variant RAGB1, resulting in the short isoform.
    Source sequence(s)
    BC034726, DB246060, DB252202
    Consensus CDS
    CCDS14371.1
    UniProtKB/Swiss-Prot
    Q5VZM2
    Related
    ENSP00000364077, OTTHUMP00000023403, ENST00000374941, OTTHUMT00000056879
    Conserved Domains (2) summary
    cd11384
    Location:42325
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
    pfam04670
    Location:42268
    Gtr1_RagA; Gtr1/RagA G protein conserved region
  2. NM_016656.3NP_057740.2  ras-related GTP-binding protein B long isoform

    See identical proteins and their annotated locations for NP_057740.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (RAGBl) represents the longest transcript and encodes the long isoform.
    Source sequence(s)
    BC034726, DB246060, DB252202, X90530
    Consensus CDS
    CCDS14372.1
    UniProtKB/Swiss-Prot
    Q5VZM2
    Related
    ENSP00000262850, OTTHUMP00000023402, ENST00000262850, OTTHUMT00000056878
    Conserved Domains (2) summary
    cd11384
    Location:42353
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
    pfam04670
    Location:42296
    Gtr1_RagA; Gtr1/RagA G protein conserved region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    55717677..55759333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261973.3XP_005262030.1  

    See identical proteins and their annotated locations for XP_005262030.1

    Conserved Domains (2) summary
    cd11384
    Location:4315
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B
    pfam04670
    Location:4258
    Gtr1_RagA; Gtr1/RagA G protein conserved region
  2. XM_005261975.2XP_005262032.1  

    Conserved Domains (2) summary
    pfam04670
    Location:42232
    Gtr1_RagA; Gtr1/RagA G protein conserved region
    cl21455
    Location:42232
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_244465.2 RNA Sequence

  2. XR_244464.2 RNA Sequence

  3. XR_938361.1 RNA Sequence

  4. XR_430513.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    55734228..55775318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)