IKZF1 IKAROS family zinc finger 1 (Ikaros) [Homo sapiens] - Gene

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Summary

Official Symbol: IKZF1provided by HGNC
Official Full Name: IKAROS family zinc finger 1 (Ikaros)provided by HGNC
Primary source: HGNC:13176
See related: Ensembl:ENSG00000185811; HPRD:04318; MIM:603023; Vega:OTTHUMG00000155907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IK1; LYF1; hIk-1; IKAROS; PRO0758; ZNFN1A1; Hs.54452
Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly

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Genomic context

Location :: 7p13-p11.1

Sequence :: Chromosome: 7; NC_000007.13 (50344378..50367358); Chromosome: 7; NC_000007.13 (50444231..50472799)

See IKZF1 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a critical role of IKAROS in human hematopoiesis and immune development.
Title: Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene.
review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function
Title: Ikaros and tumor suppression in acute lymphoblastic leukemia.
Association analysis identified five SLE susceptibility genes reaching genome-wide levels of significance : NCF2 ,IKZF1 ,IRF8 ,IFIH1 , and TYK2
Title: Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.
association between IKZF1 deletions and event-free survival in children with B-cell progenitor acute lymphoblastic leukemia was independent of age, leukocyte count at presentation, and cytogenetic subtype
Title: IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan.
IKZF1 is a secondary and probable postnatal mutation in childhood Ph(+) acute lymphoblastic leukemia.
Title: Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia.
Single nucleotide polymorphism in Ikaros gene is associated with childhood acute lymphoblastic leukemia.
Title: Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population.
these results not only provide the first evidence that long-range epigenetic silencing can have functional specific effects in cancer but also identify several deregulated Ikaros targets that may contribute to progression in colorectal adenocarcinoma.
Title: Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells.
Overexpression of Ikaros isoform 6 is associated with acute lymphoblastic leukemia.
Title: Expression of Ikaros isoform 6 in chinese children with acute lymphoblastic leukemia.
Our results suggest that decreased expression of IKZF1 mRNA may be correlated with the pathogenesis of systemic lupus erythematosus.
Title: Down-regulated expression of IKZF1 mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH syndrome than in Cushing disease of IKZF1
Title: Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors.

Submit: New GeneRIF Correction See all (61)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

Germline genomic variants associated with childhood acute lymphoblastic leukemia.

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13422	Q96CW1	AP2M1	HPRD	PubMed
Q13422	Q12873	CHD3	HPRD	PubMed
Q13422	Q13363	CTBP1	HPRD	PubMed
Q13422	Q00403	GTF2B	HPRD	PubMed
Q13422	Q13547	HDAC1	HPRD	PubMed
Q13422	Q92769	HDAC2	HPRD	PubMed
Q13422	Q9UKS7	IKZF2	HPRD	PubMed
Q13422	Q9UKT9	IKZF3	HPRD	PubMed
Q13422	Zinc finger protein, subfamily 1A, member 4	IKZF4	HPRD	PubMed
Q13422	Q99708	RBBP8	HPRD	PubMed
Q13422	O00422	SAP18	HPRD	PubMed
Q13422	Q96ST3	SIN3A	HPRD	PubMed
Q13422	O75182	SIN3B	HPRD	PubMed
Q13422	P51532	SMARCA4	HPRD	PubMed
Q13422	P20226	TBP	HPRD	PubMed
Q13422	P63279	UBE2I	HPRD	PubMed
BioGRID:115604	BioGRID:107587	AP2M1	BioGRID	PubMed	Two-hybrid
BioGRID:115604	BioGRID:115555	CDK2AP2	BioGRID	PubMed	Two-hybrid
BioGRID:115604	BioGRID:107533	CHD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:119824	CSNK1G1	BioGRID	PubMed	Two-hybrid
BioGRID:115604	BioGRID:107869	CTBP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115604	BioGRID:108893	GATA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:109214	GTF2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:115604	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:115106	HDAC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:119613	HDAC7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:116485	IKZF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:122146	IKZF4	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115604	BioGRID:122147	IKZF5	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:115604	BioGRID:204702	Ikzf3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:114974	NCOR2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:116237	NUDT21	BioGRID	PubMed	Two-hybrid
BioGRID:115604	BioGRID:111867	RBBP8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:116901	SIN3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:112489	SMARCE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:203256	Sin3a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:203257	Sin3b	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115604	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:115604	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid
BioGRID:115604	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell differentiation	IEA Inferred from Electronic Annotation more info
Peyer's patch development	IEA Inferred from Electronic Annotation more info
T cell differentiation	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
chromatin modification	IEA Inferred from Electronic Annotation more info
forebrain development	IEA Inferred from Electronic Annotation more info
gland development	IEA Inferred from Electronic Annotation more info
hemopoiesis	IEA Inferred from Electronic Annotation more info
lymph node development	IEA Inferred from Electronic Annotation more info
mesoderm development	TAS Traceable Author Statement more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of NK T cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
positive regulation of neutrophil differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
thymus development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centromeric heterochromatin	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: DNA-binding protein Ikaros

Names: DNA-binding protein Ikaros; CLL-associated antigen KW-6; Ikaros (zinc finger protein); ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein, subfamily 1A, 1 (Ikaros)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001220765.1 → NP_001207694.1 DNA-binding protein Ikaros isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Ik-x) missing an internal protein segment compared to isoform 1. This isoform contains requisite three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Related

ENSP00000352123, OTTHUMP00000208888, ENST00000359197, OTTHUMT00000342243

Conserved Domains (1) summary

pfam13465
Location:132 – 156
Blast Score: 98

zf-H2C2_2; Zinc-finger double domain
NM_001220766.1 → NP_001207695.1 DNA-binding protein Ikaros isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region compared to variant 1. This results in a shorter isoform (3, also known as Ik-2) missing an internal protein segment compared to isoform 1. This isoform is localized in the nucleus, and contains requisite three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).

Source sequence(s)

AK303586, BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Related

ENSP00000342750, ENST00000343574

Conserved Domains (2) summary

pfam13465
Location:72 – 97
Blast Score: 89

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:59 – 80
Blast Score: 75

zf-C2H2; Zinc finger, C2H2 type
NM_001220767.1 → NP_001207696.1 DNA-binding protein Ikaros isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame coding exon in the 5' region, and uses an alternate in-frame donor splice site at another coding exon compared to variant 1. This results in a shorter isoform (4, also known as Ik-2(del)) missing two internal protein segments compared to isoform 1. This isoform contains requisite three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).

Source sequence(s)

AK303586, BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Conserved Domains (2) summary

pfam13465
Location:72 – 97
Blast Score: 89

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:59 – 80
Blast Score: 75

zf-C2H2; Zinc finger, C2H2 type
NM_001220768.1 → NP_001207697.1 DNA-binding protein Ikaros isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (5, also known as Ik-3) missing an internal protein segment compared to isoform 1. This isoform contains requisite three N-terminal zinc finger motifs for high affinity DNA binding.

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Related

ENSP00000349928, ENST00000357364

Conserved Domains (1) summary

pfam13465
Location:132 – 156
Blast Score: 97

zf-H2C2_2; Zinc-finger double domain
NM_001220769.1 → NP_001207698.1 DNA-binding protein Ikaros isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (6, also known as Ik-4) missing two internal protein segments compared to isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

AK303586, BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Conserved Domains (2) summary

pfam13465
Location:72 – 97
Blast Score: 91

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:59 – 80
Blast Score: 76

zf-C2H2; Zinc finger, C2H2 type
NM_001220770.1 → NP_001207699.1 DNA-binding protein Ikaros isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks two in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon compared to variant 1. This results in a shorter isoform (7, also known as Ik-4(del)) missing three internal protein segments compared to isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

AK303586, BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Conserved Domains (2) summary

pfam13465
Location:72 – 97
Blast Score: 90

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:59 – 80
Blast Score: 76

zf-C2H2; Zinc finger, C2H2 type
NM_001220771.1 → NP_001207700.1 DNA-binding protein Ikaros isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (8, also known as Ik-5) missing an internal protein segment compared to isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant negative isoform.

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Related

ENSP00000342485, ENST00000349824
NM_001220772.1 → NP_001207701.1 DNA-binding protein Ikaros isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks four consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (9, also known as Ik-6) missing an internal protein segment compared to isoform 1. This isoform contains no N-terminal zinc finger motif, is localized in the cytoplasm, and functions as a non-DNA-binding, dominant negative isoform (PMIDs:12937159, 10463586).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422
NM_001220773.1 → NP_001207702.1 DNA-binding protein Ikaros isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (10, also known as Ik-7) missing an internal protein segment compared to isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422
NM_001220774.1 → NP_001207703.1 DNA-binding protein Ikaros isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks two consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon compared to variant 1. This results in a shorter isoform (11, also known as Ik-7(del)) missing two internal protein segments compared to isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422
NM_001220775.1 → NP_001207704.1 DNA-binding protein Ikaros isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks three consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (12, also known as Ik-8) missing an internal protein segment compared to isoform 1. This isoform contains no N-terminal zinc finger motif, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422
NM_001220776.1 → NP_001207705.1 DNA-binding protein Ikaros isoform 13

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks three consecutive in-frame coding exons, and uses an alternate in-frame donor splice site at another coding exon compared to variant 1. This results in a shorter isoform (13, also known as Ik-8(del)) missing two internal protein segments compared to isoform 1. This isoform contains no N-terminal zinc finger motif, and represents a non-DNA-binding, dominant negative isoform (PMID:9892693).

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422
NM_006060.4 → NP_006051.1 DNA-binding protein Ikaros isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Ik-1). This isoform contains four N-terminal zinc finger motifs, binds DNA, and is localized in the nucleus.

Source sequence(s)

BC018349, BC075820, BI767330, CA447462, DA944555, U40462

UniProtKB/Swiss-Prot

Q13422

Related

ENSP00000331614, OTTHUMP00000208887, ENST00000331340, OTTHUMT00000342242

Conserved Domains (2) summary

COG5048
Location:143 – 405
Blast Score: 84

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:132 – 156
Blast Score: 96

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

50344378..50367358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

50224730..50247709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

50381631..50478870

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC124014.3 (57315..62167)	None
genomic	AC233268.2 (3274..26253)	None
genomic	CH236955.1	EAL23900.1
genomic	CH471128.2	EAW60977.1
		EAW60978.1
		EAW60979.1
		EAW60980.1
		EAW60981.1
		EAW60982.1
mRNA	AF116605.1	AAF71030.1
mRNA	AF432219.1	AAL99925.1
mRNA	AK303586.1	BAG64603.1
mRNA	AK308411.1	None
mRNA	AM085310.1	CAJ29975.1
mRNA	AY377974.1	AAR84585.1
mRNA	BC018349.1	AAH18349.1
mRNA	BC064594.1	None
mRNA	BC075820.1	None
mRNA	BF797348.1	None
mRNA	BI767330.1	None
mRNA	BT009836.1	AAP88838.1
mRNA	BU665456.1	None
mRNA	CA447462.1	None
mRNA	DA944555.1	None
mRNA	S80876.1	AAB50683.1
mRNA	U40462.1	AAC50459.1
other-genetic	HQ448309.1	ADQ32789.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q13422.1	GenPept	UniProtKB/Swiss-Prot:Q13422
Q3T907	GenPept	UniProtKB/TrEMBL:Q3T907
Q69BM4	GenPept	UniProtKB/TrEMBL:Q69BM4
Q8TDG7	GenPept	UniProtKB/TrEMBL:Q8TDG7
Q9P1M1	GenPept	UniProtKB/TrEMBL:Q9P1M1