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DUSP4 dual specificity phosphatase 4 [ Orycteropus afer afer ]

Gene ID: 103198521, updated on 11-Mar-2024

Summary

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Gene symbol
DUSP4
Gene description
dual specificity phosphatase 4
Gene type
protein coding
RefSeq status
MODEL
Organism
Orycteropus afer afer (sub-species: afer)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
101 current OryAfe1.0 (GCF_000298275.1) Unplaced Scaffold NW_006921682.1 (9677886..9693015)

NW_006921682.1Genomic Context describing neighboring genes Neighboring gene thiamine transporter 2-like Neighboring gene spindle and kinetochore-associated protein 2-like Neighboring gene 5'-3' exoribonuclease 2-like Neighboring gene poly [ADP-ribose] polymerase tankyrase-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006921682 Unplaced Scaffold Reference OryAfe1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoderm formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Orycteropus afer afer Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryAfe1.0 Primary Assembly

Genomic

  1. NW_006921682.1 Reference OryAfe1.0 Primary Assembly

    Range
    9677886..9693015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007942698.2 → XP_007940889.1  dual specificity protein phosphatase 4

    UniProtKB/TrEMBL
    A0A8B6ZYX4
    Conserved Domains (2) summary
    cd00127
    Location:195 → 331
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:9 → 158
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
Nucleotide Protein
Heading Accession and Version

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