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c8a complement component 8, alpha polypeptide [ Callorhinchus milii (elephant shark) ]

Gene ID: 103185285, updated on 11-Mar-2024

Summary

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Gene symbol
c8a
Gene description
complement component 8, alpha polypeptide
See related
Ensembl:ENSCMIG00000019480
Gene type
protein coding
RefSeq status
MODEL
Organism
Callorhinchus milii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
101 current IMCB_Cmil_1.0 (GCF_018977255.1) Unplaced Scaffold NW_024704746.1 (2671242..2679711, complement)
100 previous assembly Callorhinchus_milii-6.1.3 (GCF_000165045.1) Unplaced Scaffold NW_006890165.1 (2357917..2367697, complement)

NW_024704746.1Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1a Neighboring gene complement component 8, beta polypeptide Neighboring gene FYN binding protein 2 Neighboring gene protein kinase, AMP-activated, alpha 2 catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elephant shark genome provides unique insights into gnathostome evolution. Venkatesh B, et al. Nature, 2014 Jan 9. PMID 24402279, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement component C8 alpha chain
Names
complement C8 alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Callorhinchus milii Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference IMCB_Cmil_1.0 Primary Assembly

Genomic

  1. NW_024704746.1 Reference IMCB_Cmil_1.0 Primary Assembly

    Range
    2671242..2679711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007903705.2 → XP_007901896.2  complement component C8 alpha chain

    UniProtKB/TrEMBL
    A0A4W3JVJ7
    Conserved Domains (3) summary
    smart00209
    Location:536 → 578
    TSP1; Thrombospondin type 1 repeats
    smart00457
    Location:293 → 487
    MACPF; membrane-attack complex / perforin
    cd00112
    Location:108 → 139
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
Nucleotide Protein
Heading Accession and Version

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