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EGFR epidermal growth factor receptor [ Erinaceus europaeus (western European hedgehog) ]

Gene ID: 103124504, updated on 11-Apr-2024

Summary

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Gene symbol
EGFR
Gene description
epidermal growth factor receptor
Gene type
protein coding
RefSeq status
MODEL
Organism
Erinaceus europaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae; Erinaceus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current mEriEur2.1 (GCF_950295315.1) 14 NC_080175.1 (32577064..32787200, complement)
101 previous assembly EriEur2.0 (GCF_000296755.1) Unplaced Scaffold NW_006804711.1 (435042..495500, complement)

Chromosome 14 - NC_080175.1Genomic Context describing neighboring genes Neighboring gene VOPP1 WW domain binding protein Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC132532776 Neighboring gene uncharacterized LOC132532777 Neighboring gene B-cell lymphoma/leukemia 10-like Neighboring gene uncharacterized LOC132532778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_950295315.1-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mEriEur2.1

Genomic

  1. NC_080175.1 Reference mEriEur2.1

    Range
    32577064..32787200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060171534.1 → XP_060027517.1  epidermal growth factor receptor isoform X1

  2. XM_007535219.3 → XP_007535281.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A1S3AHV3
    Conserved Domains (8) summary
    smart00219
    Location:661 → 916
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:500 → 546
    FU; Furin-like repeats
    cd00064
    Location:179 → 222
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:652 → 964
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    cl17045
    Location:582 → 625
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00757
    Location:133 → 283
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 116
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:453 → 584
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
Heading Accession and Version

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