RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_006051.3 → NP_006042.3 amyloid beta A4 precursor protein-binding family B member 3 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) encodes the longest isoform (d).
- Source sequence(s)
-
AB209839, AF224711, BC013158, BF448559
- Consensus CDS
-
CCDS4227.1
- UniProtKB/Swiss-Prot
-
O95704
- UniProtKB/TrEMBL
-
Q59EH2
- UniProtKB/TrEMBL
-
Q96DX9
- Related
- ENSP00000346378, OTTHUMP00000159887, ENST00000354402, OTTHUMT00000251676
- Conserved Domains (2) summary
-
- cd00201
Location:32 – 61
Blast Score: 98
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:116 – 261
Blast Score: 424
- PH-like; Pleckstrin homology-like domain
-
NM_133172.2 → NP_573418.2 amyloid beta A4 precursor protein-binding family B member 3 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks a 6 nt miniexon in the coding region but maintains the same reading frame as transcript variant 4. As a result, variant 3 encodes isoform c which lacks 2 internal aa as compared to isoform d encoded by transcript variant 4.
- Source sequence(s)
-
AB209839, AF224708, BC013158, BF448559
- Consensus CDS
-
CCDS4228.1
- UniProtKB/Swiss-Prot
-
O95704
- UniProtKB/TrEMBL
-
Q59EH2
- UniProtKB/TrEMBL
-
Q96DX9
- Related
- ENSP00000349177, OTTHUMP00000159886, ENST00000356738, OTTHUMT00000251675
- Conserved Domains (2) summary
-
- cd00201
Location:32 – 61
Blast Score: 98
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:116 – 259
Blast Score: 427
- PH-like; Pleckstrin homology-like domain
-
NM_133173.2 → NP_573419.2 amyloid beta A4 precursor protein-binding family B member 3 isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks a 21 nt miniexon in the coding region but maintains the same reading frame as transcript variant 4. As a result, variant 2 encodes isoform b which lacks 7 internal aa as compared to the longest isoform (d) encoded by transcript variant 4.
- Source sequence(s)
-
AB209839, BC013158, BF448559
- Consensus CDS
-
CCDS4229.1
- UniProtKB/Swiss-Prot
-
O95704
- UniProtKB/TrEMBL
-
Q59EH2
- UniProtKB/TrEMBL
-
Q96DX9
- Related
- ENSP00000350171, OTTHUMP00000159888, ENST00000357560, OTTHUMT00000251677
- Conserved Domains (2) summary
-
- cd00201
Location:32 – 61
Blast Score: 98
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:116 – 254
Blast Score: 431
- PH-like; Pleckstrin homology-like domain
-
NM_133174.2 → NP_573420.2 amyloid beta A4 precursor protein-binding family B member 3 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) lacks tandem 6 nt and 21 nt miniexons in the coding region but maintains the same reading frame as transcript variant 4. As a result, variant 1 encodes isoform a which lacks 9 internal aa as compared to isoform d encoded by transcript variant 4.
- Source sequence(s)
-
AB209839, AF224710, BC013158, BF448559
- Consensus CDS
-
CCDS47279.1
- UniProtKB/Swiss-Prot
-
O95704
- UniProtKB/TrEMBL
-
Q59EH2
- UniProtKB/TrEMBL
-
Q96DX9
- Related
- ENSP00000402591, OTTHUMP00000223852, ENST00000412920, OTTHUMT00000373245
- Conserved Domains (2) summary
-
- cd00201
Location:32 – 61
Blast Score: 98
- WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
- cl00273
Location:116 – 252
Blast Score: 445
- PH-like; Pleckstrin homology-like domain
RefSeqs of Annotated Genomes: Build 37.3
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000005.9 Reference GRCh37.p5 Primary Assembly
- Range
- 139937853..139944189, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000137.1 Alternate HuRef
- Range
- 135083190..135089524, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Suppressed Reference Sequence(s)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_133175.1: Suppressed sequence
- Description
- NM_133175.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
-
NM_133176.1: Suppressed sequence
- Description
- NM_133176.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.