MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase [Homo sapiens] - Gene

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Summary

Official Symbol: MARCH6provided by HGNC
Official Full Name: membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligaseprovided by HGNC
Primary source: HGNC:30550
See related: Ensembl:ENSG00000145495; HPRD:11095; MIM:613297; Vega:OTTHUMG00000162027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TEB4; DOA10; RNF176; MARCH-VI; KIAA0597
Summary: MARCH6 is an E3 ubiquitin (see MIM 191339) ligase that localizes to endoplasmic reticulum (ER) membranes (Hassink et al., 2005 [PubMed 15673284]).[supplied by OMIM, Apr 2010]

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Genomic context

Location :: 5p15.2

Sequence :: Chromosome: 5; NC_000005.9 (10353828..10435491)

See MARCH6 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TEB4 interacts with and mediates loss of type 2 iodothyronine deiodinase (D2)activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels.
Title: The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
analysis of yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4
Title: Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI).

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:115587	BioGRID:108078	DIO2		BioGRID	PubMed	Affinity Capture-Western
BioGRID:115587	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
ubiquitin-protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
integral to endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase MARCH6

Names: E3 ubiquitin-protein ligase MARCH6; doa10 homolog; protein TEB-4; RING finger protein 176; membrane-associated RING-CH protein VI; membrane-associated RING finger protein 6

NP_005876.2

EC 6.3.2.-

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005885.2 → NP_005876.2 E3 ubiquitin-protein ligase MARCH6

Status: PROVISIONAL

Source sequence(s)

AB011169

Consensus CDS

CCDS34135.1

UniProtKB/Swiss-Prot

O60337

Related

ENSP00000274140, OTTHUMP00000221092, ENST00000274140, OTTHUMT00000366919

Conserved Domains (2) summary

COG5183
Location:386 – 506
Blast Score: 161

SSM4; Protein involved in mRNA turnover and stability [RNA processing and modification]

cl15348
Location:8 – 56
Blast Score: 212

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

10353828..10435491

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

10338098..10419597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC012640.12	None
genomic	AC092336.2 (73986..129598)	None
genomic	CH471102.2	EAX08065.1
		EAX08066.1
		EAX08067.1
genomic	CQ834252.1	CAH05341.1
mRNA	AB011169.1	BAA25523.1
mRNA	AF009301.1	AAB66840.1
mRNA	AK000970.1	BAG50840.1
mRNA	AK296585.1	BAG59204.1
mRNA	AK299339.1	BAG61341.1
mRNA	AK300034.1	BAG61845.1
mRNA	AK314686.1	BAG37238.1
mRNA	BC013761.1	None
mRNA	BC039293.1	None
mRNA	BC046148.1	AAH46148.1
mRNA	BC111494.1	None
mRNA	BC136461.1	AAI36462.1
mRNA	BC136462.1	AAI36463.1
mRNA	BC142679.1	AAI42680.1
mRNA	BC142694.1	AAI42695.1