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APC2 adenomatosis polyposis coli 2 [ Homo sapiens (human) ]

Gene ID: 10297, updated on 8-May-2016
Official Symbol
APC2provided by HGNC
Official Full Name
adenomatosis polyposis coli 2provided by HGNC
Primary source
HGNC:HGNC:24036
See related
Ensembl:ENSG00000115266 HPRD:09802; MIM:612034; Vega:OTTHUMG00000180059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APCL
Orthologs
Location:
19p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (1446268..1473244)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1446269..1473243)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene ribosomal protein S15 Neighboring gene chromosome 19 open reading frame 25 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene receptor accessory protein 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of catenin import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
adenomatous polyposis coli protein 2
Names
adenomatous polyposis coli like

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005883.2NP_005874.1  adenomatous polyposis coli protein 2

    See identical proteins and their annotated locations for NP_005874.1

    Status: VALIDATED

    Source sequence(s)
    AC027307, BC032573
    Consensus CDS
    CCDS12068.1
    UniProtKB/Swiss-Prot
    O95996
    Related
    ENSP00000233607, ENST00000233607
    Conserved Domains (5) summary
    pfam05923
    Location:11461168
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:123206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:576694
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:17862113
    APC_basic; APC basic domain
    cl09111
    Location:977
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    1446268..1473244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259475.2XP_005259532.1  

    See identical proteins and their annotated locations for XP_005259532.1

    Conserved Domains (5) summary
    pfam05923
    Location:11701192
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:147230
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:600718
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:18102137
    APC_basic; APC basic domain
    cl09111
    Location:33101
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. XM_006722607.2XP_006722670.1  

    Conserved Domains (5) summary
    pfam05923
    Location:11691191
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:147229
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:599717
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:18092136
    APC_basic; APC basic domain
    cl09111
    Location:33101
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. XM_006722608.2XP_006722671.1  

    See identical proteins and their annotated locations for XP_006722671.1

    UniProtKB/Swiss-Prot
    O95996
    Conserved Domains (5) summary
    pfam05923
    Location:11461168
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:123206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:576694
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:17862113
    APC_basic; APC basic domain
    cl09111
    Location:977
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. XM_006722610.2XP_006722673.1  

    UniProtKB/Swiss-Prot
    O95996
    Conserved Domains (5) summary
    pfam05923
    Location:11451167
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:123205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:575693
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:17852112
    APC_basic; APC basic domain
    cl09111
    Location:977
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  5. XM_006722609.2XP_006722672.1  

    See identical proteins and their annotated locations for XP_006722672.1

    UniProtKB/Swiss-Prot
    O95996
    Related
    ENSP00000442954, OTTHUMP00000263236, ENST00000535453, OTTHUMT00000449539
    Conserved Domains (5) summary
    pfam05923
    Location:11461168
    APC_crr; APC cysteine-rich region
    pfam11414
    Location:123206
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    cd00020
    Location:576694
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05956
    Location:17862113
    APC_basic; APC basic domain
    cl09111
    Location:977
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    1450140..1473245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)