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CLCN2 chloride voltage-gated channel 2 [ Panthera tigris (tiger) ]

Gene ID: 102968476, updated on 10-Mar-2024

Summary

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Gene symbol
CLCN2
Gene description
chloride voltage-gated channel 2
See related
Ensembl:ENSPTIG00000011904
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See CLCN2 in Genome Data Viewer
Location:
chromosome: C2
Exon count:
26
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) C2 NC_056668.1 (82172318..82189488)

Chromosome C2 - NC_056668.1Genomic Context describing neighboring genes Neighboring gene chordin Neighboring gene thrombopoietin Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene family with sequence similarity 131 member A Neighboring gene eukaryotic translation initiation factor 4 gamma 1 Neighboring gene small nucleolar RNA SNORD66 Neighboring gene small nucleolar RNA SNORD66

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056668.1 Chromosome C2 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
chloride channel protein 2
Names
chloride channel, voltage-sensitive 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056668.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    82172318..82189488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042957226.1 → XP_042813160.1  chloride channel protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C9K7E7
    Conserved Domains (2) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:582 → 843
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. XM_042957225.1 → XP_042813159.1  chloride channel protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C9K7E7
    Conserved Domains (2) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:582 → 843
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  3. XM_015538120.2 → XP_015393606.2  chloride channel protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C9K7E7
    Conserved Domains (2) summary
    cd03683
    Location:69 → 546
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:558 → 819
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  4. XM_042957228.1 → XP_042813162.1  chloride channel protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C9K7E7
    Conserved Domains (2) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:582 → 823
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  5. XM_042957227.1 → XP_042813161.1  chloride channel protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C9K7E7
    Conserved Domains (2) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:582 → 843
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  6. XM_042957229.1 → XP_042813163.1  chloride channel protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C9K1A6
    Conserved Domains (3) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd02205
    Location:588 → 645
    CBS_pair_SF; CBS repeat [structural motif]
    cl15354
    Location:582 → 645
    CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily

  7. XM_042957230.1 → XP_042813164.1  chloride channel protein 2 isoform X5

    Conserved Domains (3) summary
    cd03683
    Location:93 → 570
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd02205
    Location:588 → 645
    CBS_pair_SF; CBS repeat [structural motif]
    cl15354
    Location:582 → 645
    CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily

RNA

  1. XR_006207837.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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