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CBLB Cbl proto-oncogene B [ Pteropus alecto (black flying fox) ]

Gene ID: 102890283, updated on 30-Mar-2024

Summary

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Gene symbol
CBLB
Gene description
Cbl proto-oncogene B
Locus tag
PAL_GLEAN10013342
Gene type
protein coding
RefSeq status
MODEL
Organism
Pteropus alecto
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Pteropodinae; Pteropus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
102 current ASM32557v1 (GCF_000325575.1) Unplaced Scaffold NW_006430735.1 (416823..620927, complement)

NW_006430735.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112484609 Neighboring gene 5S ribosomal RNA Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006430735 Unplaced Scaffold Reference ASM32557v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Pteropus alecto Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM32557v1 Primary Assembly

Genomic

  1. NW_006430735.1 Reference ASM32557v1 Primary Assembly

    Range
    416823..620927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025050952.1 → XP_024906720.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  2. XM_006905441.3 → XP_006905503.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_006905503.1

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  3. XM_006905443.3 → XP_006905505.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:888 → 928
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  4. XM_025050949.1 → XP_024906717.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  5. XM_006905442.3 → XP_006905504.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_006905504.1

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  6. XM_025050935.1 → XP_024906703.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    L5L3B4
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:932 → 972
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 167
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
Nucleotide Protein
Heading Accession and Version

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