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TIAM2 TIAM Rac1 associated GEF 2 [ Elephantulus edwardii (Cape elephant shrew) ]

Gene ID: 102856394, updated on 10-Mar-2024

Summary

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Gene symbol
TIAM2
Gene description
TIAM Rac1 associated GEF 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Elephantulus edwardii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Macroscelidea; Macroscelididae; Elephantulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
100 current EleEdw1.0 (GCF_000299155.1) Unplaced Scaffold NW_006399774.1 (7075134..7612279)

NW_006399774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102851634 Neighboring gene NADH-cytochrome b5 reductase 1-like Neighboring gene SR-related CTD associated factor 8 Neighboring gene mitochondrial import inner membrane translocase subunit Tim23-like Neighboring gene WAS/WASL-interacting protein family member 2-like Neighboring gene mediator of RNA polymerase II transcription subunit 6-like Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene cysteine protease ATG4C-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006399774 unplaced scaffold reference EleEdw1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-lymphoma invasion and metastasis-inducing protein 2
Names
T cell lymphoma invasion and metastasis 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Elephantulus edwardii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EleEdw1.0

Genomic

  1. NW_006399774.1 Reference EleEdw1.0

    Range
    7075134..7612279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006882752.1 → XP_006882814.1  T-lymphoma invasion and metastasis-inducing protein 2

    Conserved Domains (6) summary
    cd00992
    Location:884 → 967
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:503 → 628
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1290 → 1460
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00169
    Location:505 → 617
    PH; PH domain
    pfam00621
    Location:1099 → 1288
    RhoGEF; RhoGEF domain
    cl00155
    Location:807 → 882
    UBQ; Ubiquitin-like proteins

  2. XM_006882753.1 → XP_006882815.1  T-lymphoma invasion and metastasis-inducing protein 2

    Conserved Domains (4) summary
    cd00992
    Location:263 → 346
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01255
    Location:669 → 839
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00621
    Location:478 → 667
    RhoGEF; RhoGEF domain
    cl00155
    Location:186 → 261
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version

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