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    CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [ Homo sapiens ]

    Gene ID: 1027, updated on 20-May-2012
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    Summary

    Official Symbol
    CDKN1Bprovided by HGNC
    Official Full Name
    cyclin-dependent kinase inhibitor 1B (p27, Kip1)provided by HGNC
    Primary source
    HGNC:1785
    See related
    Ensembl:ENSG00000111276; HPRD:02867; MIM:600778; Vega:OTTHUMG00000149914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIP1; MEN4; CDKN4; MEN1B; P27KIP1
    Summary
    This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12p13.1-p12
    Sequence :
    Chromosome: 12; NC_000012.11 (12870302..12875305)
    See CDKN1B in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene G protein-coupled receptor 19 Neighboring gene apolipoprotein L domain containing 1 Neighboring gene syntaxin 8 pseudogene Neighboring gene microRNA 613

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. p27(Kip1) controls cytokinesis via the regulation of citron kinase activation. Serres MP, et al. J Clin Invest, 2012 Mar 1. PMID 22293177.
    2. Loss of p27KIP1 expression in fully-staged node-negative breast cancer: association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinoma. Mirchandani D, et al. Anticancer Res, 2011 Dec. PMID 22199306.
    3. XLGαolf regulates expression of p27Kip1 in a CSN5 and CDK2 dependent manner. Akita K, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22120635.
    4. Differential Akt signalling in non-seminomatous testicular germ cell tumors. Hennenlotter J, et al. Anticancer Res, 2011 Nov. PMID 22110200.
    5. Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus. Andrés-Pons A, et al. Cell Signal, 2012 Feb. PMID 22036806.

    See all (613) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. repression of CUGBP1 by siRNA transfection enhanced p27 protein levels and stimulated p27 IRES activity
      Title: CUG-binding protein represses translation of p27Kip1 mRNA through its internal ribosomal entry site.
    2. Data suggest that p27KIP1 has a crucial proapoptotic role in malignant mesothelioma (MM) cells treated with SRC inhibitors.
      Title: New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization.
    3. p27 has a role in cytokinesis via the regulation of citron-K activity
      Title: p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
    4. Expression of p15, p18 and p27 was not generally related to the MEN1 gene mutational status of the investigated 18 pancreatic endocrine tumours.
      Title: Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours.
    5. these data indicate that RPS13 could promote the growth and cell cycle progression of gastric cancer cells at least through inhibiting p27(kip1) expression.
      Title: Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27(Kip1).
    6. Cathepsin B and uPAR downregulation reduced tumor growth and increased p27 nuclear expression in vivo.
      Title: Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.
    7. in MCF-7 breast cancer cells, abrogation of phosphorylation of Ser(10) in p27(Kip1)resulted in significant changes in gene expression profiles which mediate cell cycle redistribution, sub-cellular localization.
      Title: Variation of gene expression profile linked to p27 (Kip1) Ser(10) phosphorylation status in MCF-7 cell line.
    8. lack of magnesium may increase p21(Cip1) and p27(Kip1) levels mediated by the decrease in ATP content and the activation of p53, resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells
      Title: Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells.
    9. Novel oncogenic function of p27Kip1: retention and destabilization of the pro-apoptotic PTEN outside of the nucleus.
      Title: Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.
    10. p21 and p27 were identified as the primary molecular targets of Arsenic trioxide against breast cancer.
      Title: Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide.
    Submit: New GeneRIF Correction See all (487)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Multiple endocrine neoplasia, type IV

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells PubMed
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000012.9 NP_001446.1 FOXO3    BIND  PubMed FOXO3a interacts with p27Kip1 promoter. 
    NP_004055.1 NP_003905.1 CCNA1    BIND  PubMed cyclin A1 interacts with p27. 
    NP_004055.1 NP_001228.1 CCNA2    BIND  PubMed p27 interacts with Cyc A. 
    NP_004055.1 NP_001228.1 CCNA2    BIND  PubMed p27 interacts with cyclin A. 
    NP_004055.1 NP_001228.1 CCNA2    BIND  PubMed p27 interacts with cyclin A. 
    NP_004055.1 NP_444284.1 CCND1    BIND  PubMed p27 interacts with cyclin D. 
    NP_004055.1 CCNE1    BIND  PubMed p27 interacts with Cyc E. 
    NP_004055.1 CCNE1    BIND  PubMed p27 interacts with cyclin E. 
    NP_004055.1 CDK2    BIND  PubMed Cdk2 interacts with p27. 
    NP_004055.1 CDK2    BIND  PubMed p27 interacts with an unspecified isoform of CDK2. 
    NP_004055.1 CDK2    BIND  PubMed Cdk2 interacts with p27kip1. 
    NP_004055.1 NP_006828.2 COPS5    BIND  PubMed COPS5 (CSN5) interacts with CDKN1B (p27). 
    NP_004055.1 NP_040508.1 E1A    BIND  PubMed E1A interacts with CDKN1B (P27KIP1). This interaction was modeled on a demonstrated interaction between Human adenovirus C E1A and either mouse or mink CDKN1B. 
    NP_004055.1 NP_040910.1 E1A    BIND  PubMed p27 interacts with E1A. This interaction was modelled on a demonstrated interaction between human p27 and E1A from an unspecified adenovirus. 
    NP_004055.1 NP_002257.1 KPNA2    BIND  PubMed p27 interacts with importin-alpha. 
    NP_004055.1 SKP2    BIND  PubMed Skp2 interacts with p27. 
    NP_004055.1 SKP2    BIND  PubMed CDKN1B (p27Kip1) interacts with SKP2 (p45Skp2). 
    NP_004055.1 NP_005554.1 STMN1    BIND  PubMed p27 interacts with stathmin. 
    NP_004055.1 NP_061828.1 UBB    BIND  PubMed Ub interacts with p27. 
    NP_004055.1 NP_003391.1 XPO1    BIND  PubMed p27Kip1 interacts with CRM1. 
    NP_004055.1     BIND  PubMed KPC interacts with and ubiquitinates p27Kip1. 
    NP_004055.1     BIND  PubMed The cyclin E / cdk2 complex interacts with p27. 
    NP_004055.1     BIND  PubMed KIP1 interacts with the cyclin E-CDK2 complex. 
    P46527 P00519 ABL1    HPRD  PubMed  
    P46527 P31749 AKT1    HPRD  PubMed  
    P46527 P52565 ARHGDIA    HPRD  PubMed  
    P46527 Q14790 CASP8    HPRD  PubMed  
    P46527 P78396 CCNA1    HPRD  PubMed  
    P46527 P20248 CCNA2    HPRD  PubMed  
    P46527 P14635 CCNB1    HPRD  PubMed  
    P46527 P24385 CCND1    HPRD  PubMed  
    P46527 P30279 CCND2    HPRD  PubMed  
    P46527 P30281 CCND3    HPRD  PubMed  
    P46527 O96020 CCNE2    HPRD  PubMed  
    P46527 P24941 CDK2    HPRD  PubMed  
    P46527 Q00526 CDK3    HPRD  PubMed  
    P46527 P11802 CDK4    HPRD  PubMed  
    P46527 Q00535 CDK5    HPRD  PubMed  
    P46527 P61024 CKS1B    HPRD  PubMed  
    P46527 Q92905 COPS5    HPRD  PubMed  
    P46527 Q13619 CUL4A    HPRD  PubMed  
    P46527 P62993 GRB2    HPRD  PubMed  
    P46527 O00505 KPNA3    HPRD  PubMed  
    P46527 O15131 KPNA5    HPRD  PubMed  
    P46527 P07948 LYN    HPRD  PubMed  
    P46527 P33993 MCM7    HPRD  PubMed  
    P46527 Q9UKX7 NUP50    HPRD  PubMed  
    P46527 Q13309 SKP2    HPRD  PubMed  
    P46527 P12931 SRC    HPRD  PubMed  
    P46527 P16949 STMN1    HPRD  PubMed  
    P46527 Q12933 TRAF2    HPRD  PubMed  
    P46527 P49815 TSC2    HPRD  PubMed  
    P46527 Ubiquitin B UBB    HPRD  PubMed  
    P46527 P09936 UCHL1    HPRD  PubMed  
    P46527 O14980 XPO1    HPRD  PubMed  
    P46527 P07947 YES1    HPRD  PubMed  
    P46527 P31946 YWHAB    HPRD  PubMed  
    P46527 P62258 YWHAE    HPRD  PubMed  
    P46527 P61981 YWHAG    HPRD  PubMed  
    P46527 Q04917 YWHAH    HPRD  PubMed  
    P46527 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:107461 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107461 BioGRID:106889 ARHGDIA    BioGRID  PubMed Two-hybrid 
    BioGRID:107461 BioGRID:114417 CCNA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107461 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:107334 CCND2    BioGRID  PubMed Two-hybrid 
    BioGRID:107461 BioGRID:107336 CCND3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107461 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:107432 CDC34    BioGRID  PubMed Biochemical Activity 
    BioGRID:107461 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:107456 CDK6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:107582 CKS1B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107461 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107461 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:109142 GRB2    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:107461 BioGRID:110034 KPNA1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107461 BioGRID:110038 KPNA4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107461 BioGRID:115982 NUP50    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107461 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107461 BioGRID:204839 Pin1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:117406 RCHY1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107461 BioGRID:121971 RNF123    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107461 BioGRID:128828 SPDYA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:107461 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:113099 TSC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:113100 TSC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:115691 UBAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107461 BioGRID:113162 UBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107461 BioGRID:113168 UBE2B    BioGRID  PubMed Biochemical Activity 
    BioGRID:107461 BioGRID:113170 UBE2D2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107461 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107461 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:113348 XPO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:113361 YWHAB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107461 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107461 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107461 BioGRID:113366 YWHAZ    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AKT phosphorylates targets in the cytosol, organism-specific biosystem (from REACTOME)
      AKT phosphorylates targets in the cytosol, organism-specific biosystemFollowing activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kina...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • FOXA1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXA1 transcription factor network, organism-specific biosystem
      FOXA1 transcription factor network
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian ???bottleneck??? genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertil...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cyclin-dependent protein kinase activity EXP
    Inferred from Experiment
    more info
    		  
    cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    cyclin-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transforming growth factor beta receptor, cytoplasmic mediator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    autophagic cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle EXP
    Inferred from Experiment
    more info
    		  
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cellular response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lithium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inner ear development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cellular component movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of epithelial cell proliferation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    phosphorylation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 1B
    Names
    cyclin-dependent kinase inhibitor 1B
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016341.1 RefSeqGene

      Range
      5001..10004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004064.3 → NP_004055.1  cyclin-dependent kinase inhibitor 1B

      Status: REVIEWED

      Source sequence(s)
      AC008115, AK312461, BC001971, CN311141, DA948043
      Consensus CDS
      CCDS8653.1
      UniProtKB/Swiss-Prot
      P46527
      UniProtKB/TrEMBL
      Q6I9V6
      Related
      ENSP00000228872, OTTHUMP00000195098, ENST00000228872, OTTHUMT00000313878
      Conserved Domains (1) summary
      pfam02234
      Location:30 – 80
      Blast Score: 204
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      12870302..12875305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      12639893..12644900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008115.4 (151597..152339) None
    genomic AF213700.1 AAF21058.1
    genomic AF480891.2 AAL78041.1
    genomic CH471094.1 EAW96275.1
    genomic CS566132.1 CAN37616.1
    genomic HI179180.1 CBX53898.1
    genomic S76986.1 AAD14244.1
    genomic S76988.1 AAD14244.1
    genomic X84849.1 CAA59284.1
    genomic Z61220.1 None
    genomic Z61221.1 None
    mRNA AB451291.1 BAG70105.1
    mRNA AB451423.1 BAG70237.1
    mRNA AF247551.1 AAF69497.1
    mRNA AJ616234.1 CAE82383.1
    mRNA AK298335.1 BAG60584.1
    mRNA AK312461.1 BAG35368.1
    mRNA AY004255.1 AAF88142.1
    mRNA BC001971.1 AAH01971.1
    mRNA BG701047.1 None
    mRNA BT019553.1 AAV38360.1
    mRNA BT019554.1 AAV38361.1
    mRNA CN311141.1 None
    mRNA CR457399.1 CAG33680.1
    mRNA DA948043.1 None
    mRNA U10906.1 AAA20240.1
    other-genetic AM392564.1 CAL37442.1
    other-genetic AM393540.1 CAL38417.1
    other-genetic AM393634.1 CAL38510.1
    other-genetic AM393862.1 CAL38737.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43806 GenPept UniProtKB/TrEMBL:O43806
    P46527.1 GenPept UniProtKB/Swiss-Prot:P46527
    Q6I9V6 GenPept UniProtKB/TrEMBL:Q6I9V6
    Q708J1 GenPept UniProtKB/TrEMBL:Q708J1
    Q96TE0 GenPept UniProtKB/TrEMBL:Q96TE0
    Q9NYG6 GenPept UniProtKB/TrEMBL:Q9NYG6
    Q9UH60 GenPept UniProtKB/TrEMBL:Q9UH60
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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