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ZMPSTE24 zinc metallopeptidase STE24 [ Homo sapiens (human) ]

Gene ID: 10269, updated on 8-May-2016
Official Symbol
ZMPSTE24provided by HGNC
Official Full Name
zinc metallopeptidase STE24provided by HGNC
Primary source
HGNC:HGNC:12877
See related
Ensembl:ENSG00000084073 HPRD:07349; MIM:606480; Vega:OTTHUMG00000005762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGPS; PRO1; FACE1; STE24; FACE-1; Ste24p
Summary
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p34
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (40258050..40294184)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40723722..40759856)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene rearranged L-myc fusion Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene collagen type IX alpha 2 Neighboring gene ribosomal protein L21 pseudogene 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of zinc metallopeptidase (STE24 homolog, ZMPSTE24) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol In both human and mouse fibroblasts, HIV-1 protease inhibitors inhibit ZMPSTE24, resulting in a significant accumulation of prelamin A, suggesting the interaction between HIV-1 PR and ZMPSTE24 PubMed

Go to the HIV-1, Human Interaction Database

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Terpenoid backbone biosynthesis, organism-specific biosystem (from KEGG)
    Terpenoid backbone biosynthesis, organism-specific biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
  • Terpenoid backbone biosynthesis, conserved biosystem (from KEGG)
    Terpenoid backbone biosynthesis, conserved biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14968

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
CAAX-box protein processing IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope organization IEA
Inferred from Electronic Annotation
more info
 
prenylated protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
CAAX prenyl protease 1 homolog
Names
farnesylated proteins-converting enzyme 1
prenyl protein-specific endoprotease 1
zinc metallopeptidase STE24 homolog
zinc metalloproteinase Ste24 homolog
NP_005848.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008695.1 RefSeqGene

    Range
    4990..41124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_212

mRNA and Protein(s)

  1. NM_005857.4NP_005848.2  CAAX prenyl protease 1 homolog

    See identical proteins and their annotated locations for NP_005848.2

    Status: REVIEWED

    Source sequence(s)
    AA436253, AB016068, AK075007, DA398037, DB096663
    Consensus CDS
    CCDS449.1
    UniProtKB/Swiss-Prot
    O75844
    Related
    ENSP00000361845, OTTHUMP00000006394, ENST00000372759, OTTHUMT00000015766
    Conserved Domains (1) summary
    pfam01435
    Location:202468
    Peptidase_M48; Peptidase family M48

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    40258050..40294184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540487.1XP_011538789.1  

    Conserved Domains (1) summary
    cl12018
    Location:202256
    Peptidase_M48; Peptidase family M48
  2. XM_011540486.1XP_011538788.1  

    Conserved Domains (1) summary
    pfam01435
    Location:119385
    Peptidase_M48; Peptidase family M48

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    40839331..40875788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)